SPHINGOSYLPHOSPHORYLCHOLINE
- Product Name
- SPHINGOSYLPHOSPHORYLCHOLINE
- CAS No.
- 1670-26-4
- Chemical Name
- SPHINGOSYLPHOSPHORYLCHOLINE
- Synonyms
- SPC;MGC119002;D-ERYTHRO-SPC;Lyso SM (d18:1);LYSO-SPHINGOMYELIN;urocortin 3 (stresscopin);Lyso-Sphingomyelin (d18:1);SPHINGOSYLPHOSPHORYLCHOLINE;spingosyl-phosphorylcholine;Sphingenyl-1-phosphorylcholine
- CBNumber
- CB2356664
- Molecular Formula
- C23H49N2O5P
- Formula Weight
- 464.62
- MOL File
- 1670-26-4.mol
SPHINGOSYLPHOSPHORYLCHOLINE Property
- Melting point:
- 90-102°C
- storage temp.
- -20°C
- solubility
- chloroform/methanol (2:1): complete10 mg/ml, clear to slightly hazy, colorless to light yellow
- form
- powder
- color
- light yellow
- BRN
- 7342520
Safety
- WGK Germany
- 3
- F
- 1-8-10
N-Bromosuccinimide Price
- Product number
- 10007947
- Product name
- Lyso-Sphingomyelin (d18:1)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 10007947
- Product name
- Lyso-Sphingomyelin (d18:1)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $401
- Updated
- 2024/03/01
- Product number
- S4257
- Product name
- Sphingosylphosphoryl-choline
- Purity
- ≥98%, powder
- Packaging
- 10mg
- Price
- $332
- Updated
- 2024/03/01
- Product number
- S4257
- Product name
- Sphingosylphosphoryl-choline
- Purity
- ≥98%, powder
- Packaging
- 25mg
- Price
- $473.4
- Updated
- 2024/03/01
- Product number
- 567735
- Product name
- Sphingosylphosphoryl-choline
- Packaging
- 10mg
- Price
- $535
- Updated
- 2024/03/01
SPHINGOSYLPHOSPHORYLCHOLINE Chemical Properties,Usage,Production
Chemical Properties
Yellowish Waxy Solid
Uses
Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.
Uses
Neurotrophic effects of Sphingosylphosphorylcholine were studied in cerebellar granule neurons of mice and PC-12 cells.
Uses
Lyso SM (d18:1) has been used:
- to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayers
- as an inhibitor of Ca2+ sensor calmodulin (CaM)
- as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions
Definition
ChEBI: Sphingosine-1-phosphocholine is a phosphosphingolipid consisting of sphingosine having a phosphocholine moiety attached to its primary hydroxyl group. It is a phosphosphingolipid, a member of phosphocholines and an ammonium betaine. It is functionally related to a sphingosine. It is a conjugate base of a sphingosylphosphocholine acid and a sphingosine-1-phosphocholine(1+).
General Description
Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.
Biochem/physiol Actions
Sphingosylphosphorylcholine (SPC) is a bioactive lipid that mediates intracellular and extracellular signaling. It mobilizes Ca2+ from intracellular stores via an IP3-independent pathway. It stimulates the production of CCL2 that may contribute to development of atherosclerosis. SPC is a ligand for endothelial differentiation gene receptor 3 (EDG3).
SPHINGOSYLPHOSPHORYLCHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
SPHINGOSYLPHOSPHORYLCHOLINE Suppliers
View Lastest Price from SPHINGOSYLPHOSPHORYLCHOLINE manufacturers
- Product
- SPHINGOSYLPHOSPHORYLCHOLINE 1670-26-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 200kg
- Release date
- 2020-01-10