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(3-BROMOPHENYL)ACETIC ACID METHYL ESTER

Product Name
(3-BROMOPHENYL)ACETIC ACID METHYL ESTER
CAS No.
150529-73-0
Chemical Name
(3-BROMOPHENYL)ACETIC ACID METHYL ESTER
Synonyms
Methyl 3-bromophenylacetate;Methyl3-bromophenylacetate98%;Methyl 3-bromophenylacetate 98%;METHYL 2-(3-BROMOPHENYL)ACETATE;methyl 2-(3-bromophenyl)acetatee;Methyl 2-(3-bromophenyl)acetate, 97%;(3-BROMOPHENYL)ACETIC ACID METHYL ESTER;Benzeneacetic acid, 3-bromo-, methyl ester;3-Bromophenylacetic acid methyl ester, Methyl 2-(3-bromophenyl)ethanoate
CBNumber
CB2357050
Molecular Formula
C9H9BrO2
Formula Weight
229.07
MOL File
150529-73-0.mol
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(3-BROMOPHENYL)ACETIC ACID METHYL ESTER Property

Boiling point:
268.6±15.0 °C(Predicted)
Density 
1.445±0.06 g/cm3(Predicted)
refractive index 
1.5440 to 1.5480
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Almost colorless
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Safety

Hazard Codes 
Xi
Hazard Note 
Harmful/Irritant/Keep Cold
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2804
Product name
Methyl 3-Bromophenylacetate
Purity
>98.0%(GC)
Packaging
5g
Price
$77
Updated
2025/07/31
TCI Chemical
Product number
M2804
Product name
Methyl 3-Bromophenylacetate
Purity
>98.0%(GC)
Packaging
25g
Price
$230
Updated
2025/07/31
TRC
Product number
M294990
Product name
Methyl2-(3-bromophenyl)acetate
Packaging
100g
Price
$1210
Updated
2021/12/16
AK Scientific
Product number
J92767
Product name
Methyl2-(3-bromophenyl)acetate
Packaging
1g
Price
$12
Updated
2021/12/16
Apolloscientific
Product number
OR3537
Product name
Methyl 3-Bromophenylacetate
Purity
98%
Packaging
5g
Price
$44
Updated
2021/12/16
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(3-BROMOPHENYL)ACETIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 2-(3-bromophenyl)acetate is used as a reagent to synthesize the methyl ester derivative of (R)-Flurbiprofen (F598730). (R)-Flurbiprofen is a nonsteroidal anti-inflammatory drug that exists as a racemate and also has potential application as a treatment for patients with Alzheimer’s Disease.

Synthesis

67-56-1

1878-67-7

150529-73-0

General procedure for the synthesis of methyl (3-bromophenyl)acetate from methanol and 3-bromophenylacetic acid: acetyl chloride (0.08 mL, 1.2 mmol, 0.5 eq.) and 3-bromophenylacetic acid (0.5 g, 2.3 mmol, 1.0 eq.) were added to methanol (10 mL), and the reaction mixture was refluxed for 2 hours. Upon completion of the reaction, the consumption of starting material was confirmed by TLC monitoring. The reaction mixture was concentrated and extracted with dichloromethane (DCM). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford methyl (3-bromophenyl)acetate as a colorless oil (0.525 g, 98.7% yield). The product was analyzed by LC-MS (ES), m/z = 229.0, 231.0 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ 3.61 (s, 3H), 3.70 (s, 2H), 7.26-7.30 (m, 2H), 7.43-7.46 (m, 1H), 7.48 (s, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 13, p. 2843 - 2866
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 392 - 395
[3] Patent: EP1479681, 2004, A1. Location in patent: Page 111; 112
[4] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 96
[5] Journal of Medicinal Chemistry, 1995, vol. 38, # 26, p. 4976 - 4984

(3-BROMOPHENYL)ACETIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-BROMOPHENYL)ACETIC ACID METHYL ESTER Suppliers

Americas 1 China 123 Europe 1 Germany 1 India 13 Japan 1 United Kingdom 3 United States 21 Global 164
GLR Innovations
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View Lastest Price from (3-BROMOPHENYL)ACETIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co
Product
(3-BROMOPHENYL)ACETIC ACID METHYL ESTER 150529-73-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

150529-73-0, (3-BROMOPHENYL)ACETIC ACID METHYL ESTERRelated Search:

METHYL 2-(2-BROMOPHENYL)ACETATE 4-BROMOPHENYL ACETIC ACID METHYL ESTER METHYL ALPHA-BROMOPHENYLACETATE 3-Bromophenylacetic acid 3(3'-BROMOPHENYL)-6-CHLORO-4,7-DIMETHYLCOUMARIN 3(3'-BROMOPHENYL)-7-HYDROXY-4-METHYLCOUMARIN 3(3'-BROMOPHENYL)-4,6-DIMETHYLCOUMARIN 3(3'-BROMOPHENYL)COUMARIN 7-ALLYLOXY-3(3'-BROMOPHENYL)-4-PHENYL COUMARIN 6-BROMO-3(3'-BROMOPHENYL)-8-CHLORO-4-METHYLCOUMARIN 3(3'-BROMOPHENYL)-4-PHENYLCOUMARIN 3(3'-BROMOPHENYL)-7-HYDROXYCOUMARIN 3(3'-BROMOPHENYL)-7-METHOXY-4-METHYLCOUMARIN 6-BROMO-3(3'-BROMOPHENYL)-4-METHYLCOUMARIN 3(3'-BROMOPHENYL)-6-METHYL-4-PHENYLCOUMARIN 3(3'-BROMOPHENYL)-7-METHYL-4-PHENYLCOUMARIN 3(3'-BROMOPHENYL)-6,8-DICHLORO-4-METHYLCOUMARIN 8-BROMO-3(3'-BROMOPHENYL)-6-CHLORO-4-METHYLCOUMARIN

  • (3-BROMOPHENYL)ACETIC ACID METHYL ESTER
  • Methyl 3-bromophenylacetate 98%
  • Methyl 3-bromophenylacetate
  • 3-Bromophenylacetic acid methyl ester, Methyl 2-(3-bromophenyl)ethanoate
  • Methyl3-bromophenylacetate98%
  • METHYL 2-(3-BROMOPHENYL)ACETATE
  • methyl 2-(3-bromophenyl)acetatee
  • Benzeneacetic acid, 3-bromo-, methyl ester
  • Methyl 2-(3-bromophenyl)acetate, 97%
  • 150529-73-0
  • blocks
  • Bromides
  • Carboxes
  • pharmacetical