ChemicalBook > CAS DataBase List > 2,4,6-Tri-tert-butylphenol

2,4,6-Tri-tert-butylphenol

Product Name
2,4,6-Tri-tert-butylphenol
CAS No.
732-26-3
Chemical Name
2,4,6-Tri-tert-butylphenol
Synonyms
2,4,6-Tris(tert-butyl)phenol;Phenol, 2,4,6-tri-tert-butyl-;P23;Phenol,2,4,6-tri-tert-butyl-;P 23;TM02;CRYA2;NCK5A;Voidox;CDK5P35
CBNumber
CB2357818
Molecular Formula
C18H30O
Formula Weight
262.43
MOL File
732-26-3.mol
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2,4,6-Tri-tert-butylphenol Property

Melting point:
125-130 °C (lit.)
Boiling point:
277 °C (lit.)
Density 
0.8640
vapor pressure 
0.073Pa at 25℃
refractive index 
1.5029 (estimate)
Flash point:
130 °C
storage temp. 
-70°C
solubility 
Chloroform (Slightly), DMSO (Slightly, Sonicated)
pka
12.61±0.40(Predicted)
form 
buffered aqueous glycerol solution
color 
Off-White to Pale Yellow
biological source
rabbit
Water Solubility 
insoluble
BRN 
1913256
Specific Activity
583-789nmol/min·mg
InChIKey
PFEFOYRSMXVNEL-UHFFFAOYSA-N
LogP
7.1 at 35℃
CAS DataBase Reference
732-26-3(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2,4,6-tris(1,1-dimethylethyl)-(732-26-3)
EPA Substance Registry System
2,4,6-Tris(tert-butyl)phenol (732-26-3)
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Safety

Hazard Codes 
F,C,N,Xi,Xn
Risk Statements 
11-22-34-50-53-36/37/38-51/53
Safety Statements 
26-36/37/39-45-60-61-24/25
RIDADR 
UN 2430 8/PG 3
WGK Germany 
3
RTECS 
SN3570000
F 
8-23
HazardClass 
9
PackingGroup 
III
HS Code 
29071990
Hazardous Substances Data
732-26-3(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 1670mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T49409
Product name
2,4,6-Tri-tert-butylphenol
Purity
98%
Packaging
100g
Price
$126
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB4500484
Product name
Anti-CRYAB antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μG
Price
$506
Updated
2024/03/01
Sigma-Aldrich
Product number
C0745
Product name
CDK5/p25, active, GST tagged human
Purity
PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging
10μG
Price
$525
Updated
2023/06/20
Sigma-Aldrich
Product number
SAB4500486
Product name
Anti-CRYAB antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μG
Price
$485
Updated
2023/01/07
American Custom Chemicals Corporation
Product number
CHM0007865
Product name
2,4,6-TRI-TERT-BUTYLPHENOL
Purity
95.00%
Packaging
100G
Price
$2501.06
Updated
2021/12/16
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2,4,6-Tri-tert-butylphenol Chemical Properties,Usage,Production

Chemical Properties

Solid. Insoluble in water; soluble in most organic solvents. Combustible.

Uses

2,4,6-Tri-tert-butylphenol is an antioxidant; used in preparation method of high-temperature resistant electromagnetic shielding electromagnetic bushing.

Flammability and Explosibility

Non flammable

Biological Activity

CDK5 is a member of the Cyclin-Dependent Kinase family th at is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

Purification Methods

Distil the phenol under reduced pressure and/or recrystallise it from n-hexane or several times from 95% EtOH until the EtOH solution is colourless [Balasubramanian & Bruice J Am Chem Soc 108 5495 1986]. It has also been purified by sublimation [Yuan & Bruice J Am Chem Soc 108 1643 1986, Wong et al. J Am Chem Soc 109 3428 1987]. Purification has also been achieved by passage through a silica gel column followed by recrystallisation from n-hexane [Kajii et al. J Phys Chem 91 2791 1987]. [Beilstein 6 III 2094, 6 IV 3539.]

Toxicity evaluation

In order to study the chronic toxicity of 2,4,6-tri-tert-butylphenol (TTBP), groups of 40 Slc: Wistar rats of either sex were fed a diet containing 0, 30, 100, 300, or 1000 ppm of TTBP for up to 24 months. Hematological, biochemical, and histopathological examinations performed periodically revealed slight microcytic anemia, changes in some biochemical parameters relating to liver function, and focal necrosis of liver cells following TTBP administration, and these changes observed in females were more severe than those in males. No neoplastic responses following TTBP administration were noted. Hence, it was concluded that TTBP causes liver injury characterized by focal necrosis with microcytic anemia and elevations of serum phospholipids and cholesterol levels, presumably occurring as secondary effects following the liver injury[1].

References

[1] Matsumoto, Kiyoshi , et al. "Chronic toxicity of 2,4,6-tri-tert-butylphenol in rats." Journal of Toxicological Sciences 16.4(1991):167.

2,4,6-Tri-tert-butylphenol Preparation Products And Raw materials

Raw materials

2-Chloro-2-methylpropane Phenol Aluminum chloride

Preparation Products

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2,4,6-Tri-tert-butylphenol Suppliers

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View Lastest Price from 2,4,6-Tri-tert-butylphenol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2,4,6-Tri-tert-butylphenol 732-26-3
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-07
Hebei Mujin Biotechnology Co.,Ltd
Product
2,4,6-Tri-tert-butylphenol 732-26-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-16
Hebei Weibang Biotechnology Co., Ltd
Product
2,4,6-Tri-tert-butylphenol 732-26-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-26

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