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Vinflunine

Product Name
Vinflunine
CAS No.
162652-95-1
Chemical Name
Vinflunine
Synonyms
VINFLUNINE;vinflunine（97%）;Vinflunine Tartrate;Vinflunine (F12158);Vinflunine USP/EP/BP;Vinflunine 162652-95-1;20',20'-Difluoro-3',4'-dihydrovinorelbine;4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine;Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1
CBNumber
CB2358406
Molecular Formula
C45H54F2N4O8
Formula Weight
816.94
MOL File
162652-95-1.mol
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Vinflunine Property

Density 
1.39±0.1 g/cm3(Predicted)
pka
11.36±0.60(Predicted)
CAS DataBase Reference
162652-95-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0004596
Product name
VINFLUNINE
Purity
95.00%
Packaging
5MG
Price
$501.95
Updated
2021/12/16
Crysdot
Product number
CD31003132
Product name
Vinflunine
Purity
98+%
Packaging
100mg
Price
$966
Updated
2021/12/16
AvaChem
Product number
2180
Product name
Vinflunine
Packaging
100mg
Price
$1680
Updated
2021/12/16
Crysdot
Product number
CD31003132
Product name
Vinflunine
Purity
98+%
Packaging
5mg
Price
$88
Updated
2021/12/16
AvaChem
Product number
2180
Product name
Vinflunine
Packaging
5mg
Price
$135
Updated
2021/12/16
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Vinflunine Chemical Properties,Usage,Production

Description

Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the European Medicines Agency (EMEA) in 2009 for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen. Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF5) and in the presence of a chlorinated solvent like CHCl3 or CCl4.

Originator

Pierre Fabre (France)

Definition

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.

brand name

Javlor

Clinical Use

Antineoplastic agent (vinca alkaloid):
Treatment of advanced or metastatic bladder cancer

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: possible increased risk of ventricular arrhythmias with delamanid; concentration possibly reduced by rifampicin - avoid.
Antidepressants: concentration possibly reduced by St Johns wort - avoid.
Antifungals: concentration increased by ketoconazole and possibly itraconazole (increased risk of neurotoxicity) - avoid.
Antimalarials: avoid with piperaquine with artenimol.
Antipsychotics: avoid with clozapine (increased risk of agranulocytosis).
Antivirals: concentration possibly increased by ritonavir - avoid.
Grapefruit juice: concentration of vinflunine increased - avoid.

Metabolism

Metabolised by the cytochrome CYP3A4 isoenzyme, except for 4-O-deacetylvinflunine (DVFL), the only active metabolite and main metabolite in blood which is formed by multiple esterases. Excretion occurs via the faeces (about two-thirds) and the urine (about one-third).

Vinflunine Preparation Products And Raw materials

Raw materials

Preparation Products

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Vinflunine Suppliers

Canada 1 China 79 Germany 1 India 1 United Kingdom 3 United States 12 Global 97
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
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View Lastest Price from Vinflunine manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Vinflunine 162652-95-1 162652-95-1
Price
US $30.00/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-17
Career Henan Chemical Co
Product
Vinflunine 162652-95-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
2000kg
Release date
2019-08-05

162652-95-1, VinflunineRelated Search:

(R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE 2,4-Dipentylphenol 3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID 2-TERT-BUTYL-1H-INDOLE 4-PHENYLCYCLOHEXANOL α-(p-Aminophenyl)butyric acid (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90% TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID 4-AMINOCYCLOHEXANECARBOXYLIC ACID (R)-(-)-2-HYDROXY-4-PHENYLBUTYRIC ACID Vinflunine INDOLE-2-ACETIC ACID 3,3,5,5-TETRAMETHYLCYCLOHEXANOL 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID L-LEUCIC ACID (2-METHOXY-5-METHYLPHENYL)ACETIC ACID 3-PHENETHYL-PIPERIDINE (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE

  • VINFLUNINE
  • Vinflunine 162652-95-1
  • 20',20'-Difluoro-3',4'-dihydrovinorelbine
  • 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine
  • 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine
  • Vinflunine Tartrate
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
  • Vinflunine USP/EP/BP
  • Vinflunine (F12158)
  • Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1
  • vinflunine（97%）
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
  • 162652-95-1
  • C45H54F2N4O8
  • Miscellaneous Natural Products