5-Bromopyrimidine-2-carbonitrile

Product Name: 5-Bromopyrimidine-2-carbonitrile
CAS No.: 38275-57-9
Chemical Name: 5-Bromopyrimidine-2-carbonitrile
Synonyms: Favipiravir Impurity 45;5-BROMO-2-CYANOPYRIMIDINE;2-Cyano-5-bromopyrimidine;5-bromo-pyrimidine-2-carb...;5-Bromo-2-cyanopyrimidine, 99%;5-Bromo-pyrimidine-2-carbonitiL;5-broMo-pyriMidine-2-carbonitile;5-Bromo-2-pyrimidinecarbonitrile;5-BROMOPYRIMIDINE-2-CARBONITRILE;2-PYRIMIDINECARBONITRILE, 5-BROMO-
CBNumber: CB2363606
Molecular Formula: C5H2BrN3
Formula Weight: 183.99
MOL File: 38275-57-9.mol

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5-Bromopyrimidine-2-carbonitrile Property

Boiling point:: 317.7±34.0 °C(Predicted)
Density: 1.86±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
pka: -4.65±0.22(Predicted)
form: Solid
color: White to yellow
Water Solubility: Slightly soluble in water.
Sensitive: Moisture Sensitive
InChI: InChI=1S/C5H2BrN3/c6-4-2-8-5(1-7)9-3-4/h2-3H
InChIKey: VPQICCOHFSGBMA-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=C(Br)C=N1
CAS DataBase Reference: 38275-57-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,N
Risk Statements: 20/21/22-37/38-41-50
Safety Statements: 26-36/37-39-61
RIDADR: 3077
Hazard Note: Irritant
TSCA: No
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B682893
Product name: 5-Bromo-2-cyanopyrimidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B2036
Product name: 5-Bromo-2-cyanopyrimidine
Purity: 98%
Packaging: 1g
Price: $5
Updated: 2021/12/16

Apolloscientific

Product number: OR3247
Product name: 5-Bromopyrimidine-2-carbonitrile
Packaging: 1g
Price: $15
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B2036
Product name: 5-Bromo-2-cyanopyrimidine
Purity: 98%
Packaging: 5g
Price: $17
Updated: 2021/12/16

Apolloscientific

Product number: OR3247
Product name: 5-Bromopyrimidine-2-carbonitrile
Packaging: 5g
Price: $27
Updated: 2021/12/16

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5-Bromopyrimidine-2-carbonitrile Chemical Properties,Usage,Production

Chemical Properties

Light yellow crystalline/powder

Uses

5-Bromo-2-cyanopyrimidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Preparation

5-Bromopyrimidine-2-carbonitrile is a pharmaceutical intermediate that can be obtained by reacting 5-bromo-2-chloropyrimidine with potassium nitride. It can also be obtained as follow: 5-Bromo-2-chloropyrimidine (7.51 g, 38.83 mmol), dissolved in DMSO (20 mL), is added to a mixture of NaCN (1.9 g, 38.83 mmol) and l,4-diazabicyclo[2,2,2]octane (0.87 g, 7.77 mmol) in DMSO (10 mL) and water (20 mL). The mixture is stirred overnight, and then water (100 mL) is added. The mixture is extracted with ether (3x100 mL). The combined organic layer is dried (Na2SO4), filtered, and concentrated in vacuo to afford 5-Bromopyrimidine-2-carbonitrile as a solid.

Synthesis

143-33-9

32779-36-5

38275-57-9

General procedure for the synthesis of 5-bromo-2-cyanopyrimidine from sodium cyanide and 5-bromo-2-chloropyrimidine: 1. In a reaction flask, 5-bromo-2-chloropyrimidine (10 g, 51.8 mmol) was dissolved in dimethyl sulfoxide (26 mL). 2. a mixture of sodium cyanide (2.59 g, 51.8 mmol) and triethylenediamine (1.2 g, 10.4 mmol) in dimethyl sulfoxide (14 mL) and water (28 mL) was added sequentially to the above solution. 3. The reaction mixture was stirred at room temperature for 18 hours. 4. Upon completion of the reaction, the mixture was diluted with water (130 mL) and extracted with ether (3 x 150 mL). 5. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a light yellow solid. 6. The resulting solid was purified by recrystallization from hot dichloromethane to afford the target product 5-bromo-2-cyanopyrimidine. Yield: 99% (9.4 g). 1H NMR (CDCl3, 400 MHz) δ: 8.84 (s, 2H).

References

[1] Patent: WO2005/28452, 2005, A1. Location in patent: Page/Page column 87
[2] Patent: WO2008/121670, 2008, A1. Location in patent: Page/Page column 93-94
[3] Patent: WO2008/57336, 2008, A2. Location in patent: Page/Page column 44
[4] Patent: WO2004/56369, 2004, A1. Location in patent: Page/Page column 20

5-Bromopyrimidine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Sodium sulfate 5-Bromo-2-chloropyrimidine Sodium cyanide Diethyl ether Dichloromethane Dimethyl sulfoxide Triethylenediamine

Preparation Products

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5-Bromopyrimidine-2-carbonitrile Suppliers

China 188 Germany 2 India 2 Japan 1 Poland 1 United Kingdom 4 United States 18 Global 216

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View Lastest Price from 5-Bromopyrimidine-2-carbonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromopyrimidine-2-carbonitrile 38275-57-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-28

Henan Fengda Chemical Co., Ltd

Product: 5-Bromo-2-pyrimidinecarbonitrile 38275-57-9
Price: US $122.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-11

Dideu Industries Group Limited

Product: 5-Bromopyrimidine-2-carbonitrile 38275-57-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

38275-57-9, 5-Bromopyrimidine-2-carbonitrileRelated Search:

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5-Bromopyrimidine-2-carbonitrile ISO 9001：2015 REACH

Favipiravir Impurity 45

5-Bromo-2-cyanopyrimidine, 99%

38275-57-9

C5H2BrN3

Pyrimidine

Cyano

Organohalides

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles

Heterocycle-Pyrimidine series

bromopyrimidine