(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE

Product Name: (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE
CAS No.: 2011-48-5
Chemical Name: (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE
Synonyms: USAF LA-7;(4-methoxybenzyl)hydrazinium chloride;(4-Methoxybenzyl)hydrazinehydrochloride;(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE;p-Methoxybenzylhydrazine monohydrochloride;Hydrazine, p-methoxybenzyl-, hydrochloride;[(4-methoxyphenyl)methyl]hydrazine hydrochloride;1-[(4-methoxyphenyl)methyl]hydrazine hydrochloride;(4-methoxyphenyl)methyl]-Hydrazine hydrochloride (1:1);Hydrazine, [(4-Methoxyphenyl)Methyl]-, hydrochloride (1:1)
CBNumber: CB2369653
Molecular Formula: C8H14Cl2N2O
Formula Weight: 225.12
MOL File: 2011-48-5.mol

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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Property

Melting point:: 194-195℃ (decomposition)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow to Light Yellow
Stability:: Hygroscopic
InChI: InChI=1S/C8H12N2O.2ClH/c1-11-8-4-2-7(3-5-8)6-10-9;;/h2-5,10H,6,9H2,1H3;2*1H
InChIKey: XMPHUNHAMDBTBE-UHFFFAOYSA-N
SMILES: C1C(OC)=CC=C(CNN)C=1.Cl.Cl

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Safety

HazardClass: IRRITANT
HS Code: 2928009090
Toxicity: mouse,LD50,intraperitoneal,50mg/kg (50mg/kg),National Technical Information Service. Vol. AD277-689,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M331173
Product name: (4-Methoxybenzyl)hydrazineHydrochloride
Packaging: 500mg
Price: $40
Updated: 2021/12/16

TRC

Product number: M331173
Product name: (4-Methoxybenzyl)hydrazineHydrochloride
Packaging: 5g
Price: $55
Updated: 2021/12/16

Ark Pharm

Product number: AK-33977
Product name: (4-Methoxybenzyl)hydrazinehydrochloride
Purity: 97%
Packaging: 25g
Price: $56
Updated: 2021/12/16

Matrix Scientific

Product number: 074107
Product name: (4-Methoxybenzyl)hydrazine hydrochloride
Purity: 95+%
Packaging: 1g
Price: $98
Updated: 2021/12/16

Apolloscientific

Product number: OR55590
Product name: 4-Methoxybenzylhydrazinehydrochloride
Purity: 97%
Packaging: 5g
Price: $145
Updated: 2021/12/16

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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

(4-Methoxybenzyl)hydrazine Hydrochloride is used in preparation of Heterocyclic derivatives useful as SHP2 inhibitors.

Synthesis

824-94-2

2011-48-5

Step 1: Synthesis of (4-methoxybenzyl)hydrazine hydrochloride Hydrazine hydrate (40 g, 0.80 mol) and anhydrous ethanol (280 mL) were added to a 500 mL three-necked round bottom flask. A solution of anhydrous ethanol (30 mL) of 4-methoxybenzyl chloride (12.5 g, 0.080 mol) was slowly added dropwise to the above mixture at room temperature. The reaction mixture was heated to 90 °C and stirred for 2 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent and the residue was subsequently redissolved in anhydrous ethanol (150 mL). The solution was cooled to 0 °C and acidified by slowly adding 5 M hydrochloric acid (120 mL). The precipitated white solid precipitate was collected by filtration and dried to give 8.72 g of the target product (4-methoxybenzyl)hydrazine hydrochloride in 72% yield. Mass spectrometry analysis showed m/z: 153(M+H)+.

References

[1] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 87
[2] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 189-190
[3] Patent: WO2014/139150, 2014, A1. Location in patent: Page/Page column 84; 85
[4] Patent: WO2014/150114, 2014, A1. Location in patent: Page/Page column 84; 85
[5] Patent: US2017/145026, 2017, A1. Location in patent: Paragraph 1027; 1028

(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE Suppliers

China 122 India 2 Switzerland 2 United States 11 Global 137

Accela ChemBio Inc.

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SynQuest Laboratories, Inc.

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View Lastest Price from (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE 2011-48-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE 2011-48-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-08

Career Henan Chemical Co

Product: (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE 2011-48-5
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-04

2011-48-5, (4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDERelated Search:

(R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE tert-Butyl (4-methylpiperidin-4-yl)carbamate tert-butyl (R)-3-formylpyrrolidine-1-carboxylate 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE tert-butyl N-(5-cyano-1,3-thiazol-2-yl)carbamate Hydrazine dihydrochloride

[(4-methoxyphenyl)methyl]hydrazine hydrochloride

Hydrazine, p-methoxybenzyl-, hydrochloride

p-Methoxybenzylhydrazine monohydrochloride

(4-METHOXYBENZYL)HYDRAZINE DIHYDROCHLORIDE

Hydrazine, [(4-Methoxyphenyl)Methyl]-, hydrochloride (1:1)

USAF LA-7

(4-Methoxybenzyl)hydrazinehydrochloride

(4-methoxybenzyl)hydrazinium chloride

(4-methoxyphenyl)methyl]-Hydrazine hydrochloride (1:1)

1-[(4-methoxyphenyl)methyl]hydrazine hydrochloride

2011-48-5