(3-AMINO-5-NITROPHENYL)METHANOL
- Product Name
- (3-AMINO-5-NITROPHENYL)METHANOL
- CAS No.
- 90390-46-8
- Chemical Name
- (3-AMINO-5-NITROPHENYL)METHANOL
- Synonyms
- 3-Amino-5-nitrobenzenemethanol;(3-AMINO-5-NITROPHENYL)METHANO;(3-AMINO-5-NITROPHENYL)METHANOL;3-(Hydroxymethyl)-5-nitroaniline;Benzenemethanol, 3-amino-5-nitro-
- CBNumber
- CB2377203
- Molecular Formula
- C7H8N2O3
- Formula Weight
- 168.15
- MOL File
- 90390-46-8.mol
(3-AMINO-5-NITROPHENYL)METHANOL Property
- Boiling point:
- 425.9±30.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 13.71±0.10(Predicted)
- Appearance
- Light yellow to green yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A622758
- Product name
- (3-Amino-5-nitrophenyl)methanol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W9312
- Product name
- (3-Amino-5-nitrophenyl)methanol
- Packaging
- 5g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- AAA0007123
- Product name
- (3-AMINO-5-NITROPHENYL)METHANOL
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $444
- Updated
- 2021/12/16
- Product number
- 074465
- Product name
- (3-Amino-5-nitrophenyl)methanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- AAA0007123
- Product name
- (3-AMINO-5-NITROPHENYL)METHANOL
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $780
- Updated
- 2021/12/16
(3-AMINO-5-NITROPHENYL)METHANOL Chemical Properties,Usage,Production
Synthesis
71022-43-0
90390-46-8
(ii) Synthesis of 3-amino-5-nitrobenzyl alcohol: 3,5-dinitrobenzyl alcohol (129.1 g, 0.65 mol) from step (i) was dissolved in methanol (1500 mL) and heated to reflux. Ammonium sulfide solution (450 mL, containing 20 wt% H2O, 442.9 g, 1.30 mol) was added slowly over 45 min. The resulting non-homogeneous mixture was refluxed for 2 hours, followed by stirring at 25 °C for 18 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was acidified with 2N hydrochloric acid and the methanol was evaporated under reduced pressure. The remaining acidic aqueous solution was washed with ether (3×) and then alkalized with 6N sodium hydroxide solution. The alkalized aqueous solution was extracted with ether (4×). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 95.8 g (88% yield) of 3-amino-5-nitrobenzenemethanol as an orange solid, which could be used in the next reaction without further purification. The product was characterized by 1H NMR (300 MHz, CD3OD): δ 7.46 (m, 1H), 7.38 (m, 1H), 6.98 (m, 1H), 4.57 (s, 2H).
References
[1] Tetrahedron Letters, 2003, vol. 44, # 29, p. 5477 - 5481
[2] Chinese Chemical Letters, 2011, vol. 22, # 7, p. 785 - 788
[3] Journal of Medicinal Chemistry, 1984, vol. 27, # 9, p. 1111 - 1118
[4] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 22, p. 3263 - 3265
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2002, vol. 45, # 3, p. 257 - 268
(3-AMINO-5-NITROPHENYL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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