(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL

Product Name: (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
CAS No.: 62855-02-1
Chemical Name: (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
Synonyms: H-D-Tic-ol;(R)-1,2,3,4-Tetrahydroisoquinolyl-methan-3-ol;(R)-1,2,3,4-Tetrahydroisoquinoline-3-methanol;(R)-1,2,3,4-tetrahydroisoquinolin-4-ylmethanol;(R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;(3R)-1,2,3,4-tetrahydroisoquinolin-4-ylMethanol;(3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol;(R)-(1,2,3,4-tetrahydroisoduinolin-3-yl)-Methanol;(R)-(+)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
CBNumber: CB2380641
Molecular Formula: C10H13NO
Formula Weight: 163.22
MOL File: 62855-02-1.mol

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(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Property

Boiling point:: 307.9±27.0 °C(Predicted)
Density: 1.081±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.57±0.10(Predicted)
form: Crystalline
color: White
optical activity: 101.4°(C=0.01 g/ CHCL3)

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: T293983
Product name: (3R)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK465629
Product name: (3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
Purity: 98%
Packaging: 1g
Price: $59
Updated: 2021/12/16

Ark Pharm

Product number: P000190191
Product name: (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
Purity: 95%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK465629
Product name: (3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
Purity: 98%
Packaging: 250mg
Price: $18
Updated: 2021/12/16

Ark Pharm

Product number: P000190191
Product name: (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
Purity: 95%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

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(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

(3R)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol is used in asymmetric synthesis of vinylmorpholines by palladium-catalyzed tandem allylic substitutions with amino alcohols.

Synthesis

79815-19-3

18881-17-9

GENERAL STEPS: This experimental procedure was modified with reference to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether: ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (4) as a yellow crystalline solid in a yield of 2.09 g (98% yield, melting point 95-97 °C). The spinor data were in agreement with those reported in the literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0, 47.83, 30.9. 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Suppliers

China 85 Germany 2 India 1 United Kingdom 6 United States 14 Global 108

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View Lastest Price from (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 62855-02-1
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Career Henan Chemical Co

Product: (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL 62855-02-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

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