ChemicalBook > CAS DataBase List > (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL

(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL

Product Name
(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
CAS No.
62855-02-1
Chemical Name
(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
Synonyms
H-D-Tic-ol;(R)-1,2,3,4-Tetrahydroisoquinolyl-methan-3-ol;(R)-1,2,3,4-Tetrahydroisoquinoline-3-methanol;(R)-1,2,3,4-tetrahydroisoquinolin-4-ylmethanol;(R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;(3R)-1,2,3,4-tetrahydroisoquinolin-4-ylMethanol;(3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol;(R)-(1,2,3,4-tetrahydroisoduinolin-3-yl)-Methanol;(R)-(+)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
CBNumber
CB2380641
Molecular Formula
C10H13NO
Formula Weight
163.22
MOL File
62855-02-1.mol
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(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Property

Boiling point:
307.9±27.0 °C(Predicted)
Density 
1.081±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
14.57±0.10(Predicted)
form 
Crystalline
color 
White
optical activity
101.4°(C=0.01 g/ CHCL3)
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Safety

Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
T293983
Product name
(3R)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
Packaging
250mg
Price
$55
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK465629
Product name
(3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
Purity
98%
Packaging
1g
Price
$59
Updated
2021/12/16
Ark Pharm
Product number
P000190191
Product name
(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
Purity
95%
Packaging
100mg
Price
$15
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK465629
Product name
(3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
Purity
98%
Packaging
250mg
Price
$18
Updated
2021/12/16
Ark Pharm
Product number
P000190191
Product name
(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
Purity
95%
Packaging
250mg
Price
$24
Updated
2021/12/16
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(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

(3R)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol is used in asymmetric synthesis of vinylmorpholines by palladium-catalyzed tandem allylic substitutions with amino alcohols.

Synthesis

79815-19-3

18881-17-9

GENERAL STEPS: This experimental procedure was modified with reference to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether: ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (4) as a yellow crystalline solid in a yield of 2.09 g (98% yield, melting point 95-97 °C). The spinor data were in agreement with those reported in the literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0, 47.83, 30.9. 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(R)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 62855-02-1
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99%min
Supply Ability
100KG
Release date
2025-08-20
Career Henan Chemical Co
Product
(R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL 62855-02-1
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-12

62855-02-1, (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOLRelated Search:

D-7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (S)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL-METHANOL N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid FMOC-7-HYDROXY-(R)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BOC-7-HYDROXY-D-TIC-OH narciclasine Z-D-TIC-OH (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE saframycin Mx1 D-2-BOC-7-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID H-D-TIC-OTBU HCL BOC-D-TIC-OH (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER (R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER D-2-BOC-7-(FLUORO)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID D-ETHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL

  • (R)-(+)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
  • 3(R)-HYDROXYMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
  • (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL
  • (R)-1,2,3,4-Tetrahydroisoquinolyl-methan-3-ol
  • (3R)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
  • 2-chloro-4-[[2-(diethylamino)-5-methoxyphenyl]methyl]-N,N-dimethylaniline
  • (3R)-1,2,3,4-tetrahydroisoquinolin-4-ylMethanol
  • (R)-(1,2,3,4-tetrahydroisoduinolin-3-yl)-Methanol
  • (R)-3-Hydroxymethyl-1, 2, 3, 4-tetrahydroisoquinoline
  • (R)-1,2,3,4-tetrahydroisoquinolin-4-ylmethanol
  • (R)-1,2,3,4-Tetrahydroisoquinolylmethan-3-ol, >=98%
  • (R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol
  • (R)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol,99%e.e.
  • 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (R)-
  • 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3R)-
  • (R)-1,2,3,4-Tetrahydroisoquinoline-3-methanol
  • (R)-(1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL)-METHANOL USP/EP/BP
  • H-D-Tic-ol
  • 3-isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3R), 98%min
  • 62855-02-1
  • 62855-02-2