ChemicalBook > CAS DataBase List > 2-AMINOTHIAZOLE-5-CARBONITRILE

2-AMINOTHIAZOLE-5-CARBONITRILE

Product Name
2-AMINOTHIAZOLE-5-CARBONITRILE
CAS No.
51640-52-9
Chemical Name
2-AMINOTHIAZOLE-5-CARBONITRILE
Synonyms
2-AMINO-5-CYANOTHIAZOLE;2-Amino-5-cyano-1,3-thiazole;2-AMINOTHIAZOLE-5-CARBONITRILE;2-aMino-5-thiazolecarbonitrile;5-thiazolecarbonitrile, 2-amino-;2-Aminothiazole-5-carbonitrile 97%;2-Amino-1,3-thiazole-5-carbonitrile;2-Aminothiazole-5-carbonitrile, 98%,;2-AMINOTHIAZOLE-5-CARBONITRILE, 95+%;2-Amino-1,3-thiazole-5-carbonitrile 97%
CBNumber
CB2386830
Molecular Formula
C4H3N3S
Formula Weight
125.15
MOL File
51640-52-9.mol
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2-AMINOTHIAZOLE-5-CARBONITRILE Property

Melting point:
185-187
Boiling point:
330.4±15.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
solid
pka
1.82±0.10(Predicted)
color 
Dark brown
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-41
Safety Statements 
26-39
RIDADR 
UN3439
WGK Germany 
3
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT
HazardClass 
6.1
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
714801
Product name
2-Aminothiazole-5-carbonitrile
Purity
97%
Packaging
1g
Price
$100
Updated
2023/06/20
TRC
Product number
A633338
Product name
2-Aminothiazole-5-carbonitrile
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR3230
Product name
2-Amino-1,3-thiazole-5-carbonitrile
Purity
97%
Packaging
250mg
Price
$32
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-1-7Q
Product name
2-Amino-1,3-thiazole-5-carbonitrile
Purity
97%
Packaging
250mg
Price
$36
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA122089
Product name
2-Amino-1,3-thiazole-5-carbonitrile
Packaging
250mg
Price
$40
Updated
2021/12/16
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2-AMINOTHIAZOLE-5-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

51640-51-8

51640-52-9

5-Cyano-2-trifluoroacetamido thiazole (3.32 g, 15 mmol) was used as raw material, and it was reacted with potassium carbonate (4.0 mL 10% w/v methanol/water (5:2) solution) for 3 hours at 20°C with stirring. After completion of the reaction, the insoluble material was removed by filtration, and the pH of the filtrate was adjusted to 7 with dilute hydrochloric acid and filtered again to remove the insoluble material. Subsequently, the filtrate was evaporated to remove volatiles. The residue was suspended in water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate and evaporated to remove the solvent. The resulting residue was treated with 20% aqueous fluoboric acid (40 mL) and heated at 70 °C for 1 hour. The reaction mixture was cooled, neutralized with solid sodium bicarbonate at 0 °C and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and evaporated to remove volatiles to give 2-amino-5-cyanothiazole (1.79 g, 95% yield) as a final solid product. The product was confirmed by NMR hydrogen spectrum (400.13 MHz): δ 7.83 (1H, s), 8.12 (2H, s); mass spectrum (m/z): 125 [MH]+.

References

[1] Patent: WO2007/31745, 2007, A1. Location in patent: Page/Page column 102-103
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973, p. 2769 - 2772

2-AMINOTHIAZOLE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINOTHIAZOLE-5-CARBONITRILE Suppliers

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View Lastest Price from 2-AMINOTHIAZOLE-5-CARBONITRILE manufacturers

Career Henan Chemical Co
Product
2-AMINOTHIAZOLE-5-CARBONITRILE 51640-52-9
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

51640-52-9, 2-AMINOTHIAZOLE-5-CARBONITRILERelated Search:

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  • 2-Aminothiazole-5-carbonitrile 97%
  • 2-Amino-1,3-thiazole-5-carbonitrile
  • 2-Amino-1,3-thiazole-5-carbonitrile 97%
  • 2-AMINO-5-CYANOTHIAZOLE
  • 2-AMINOTHIAZOLE-5-CARBONITRILE
  • 2-AMINOTHIAZOLE-5-CARBONITRILE, 95+%
  • 5-thiazolecarbonitrile, 2-amino-
  • 2-amino-1,3-thiazole-5-carbonitrile(SALTDATA: FREE)
  • 2-aMino-5-thiazolecarbonitrile
  • 2-Amino-5-cyano-1,3-thiazole
  • 2-Aminothiazole-5-carbonitrile, 98%,
  • 2-aminothiazole-5-carbonitrile - [A9618]
  • 51640-52-9
  • C4H3N3S
  • Amines
  • blocks
  • Carboxes
  • Thiazoles
  • Thiazole