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METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE

Product Name
METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE
CAS No.
81452-54-2
Chemical Name
METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE
Synonyms
RARECHEM AL BF 0178;3-Methylthiophene-2-Cabroxylate;3-methylthiophene-2-carboxylate;Methyl 3-methylthienyl-2-carboxylate;Eethyl3-methylthiophene-2-carboxylate;METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE;Methyl 3-Methylthiophene-2-carboxylate >Methyl 3-methylthiophene-2-carboxylate ,99%;3-Methylthiophen-2-carboxylic acid methyl ester;3-methyl-2-thiophenecarboxylic acid methyl ester
CBNumber
CB2390952
Molecular Formula
C7H8O2S
Formula Weight
156.2
MOL File
81452-54-2.mol
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METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE Property

Boiling point:
216-217°C
Density 
1.173±0.06 g/cm3(Predicted)
refractive index 
1.5168
Flash point:
216-217°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow
BRN 
116836
InChI
InChI=1S/C7H8O2S/c1-5-3-4-10-6(5)7(8)9-2/h3-4H,1-2H3
InChIKey
BRWROFVPMUPMJQ-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)SC=CC=1C
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Safety

Safety Statements 
23-24/25
HS Code 
29151300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2662
Product name
Methyl 3-Methylthiophene-2-carboxylate
Purity
>97.0%(GC)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
M2662
Product name
Methyl 3-Methylthiophene-2-carboxylate
Purity
>97.0%(GC)
Packaging
5g
Price
$79
Updated
2025/07/31
TRC
Product number
M219630
Product name
Methyl 3-Methylthiophene-2-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR953363
Product name
Methyl 3-Methylthiophene-2-carboxylate
Purity
96%
Packaging
5g
Price
$90
Updated
2021/12/16
AK Scientific
Product number
W8584
Product name
Methyl 3-Methylthiophene-2-carboxylate
Packaging
10g
Price
$90
Updated
2021/12/16
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METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Synthesis

67-56-1

23806-24-8

81452-54-2

Step 1: Synthesis of methyl 3-methylthiophene-2-carboxylate: 3-methylthiophene-2-carboxylic acid (15 g, 105 mmol, 1.0 eq.) was dissolved in methanol (150 mL) and concentrated sulfuric acid (7.5 mL) was added slowly and dropwise. The reaction mixture was heated to reflux for 12 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (200 mL) and washed sequentially with water (2 x 50 mL), saturated aqueous sodium bicarbonate solution (2 x 50 mL) and brine (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to afford 20 g (97% yield) of methyl 3-methylthiophene-2-carboxylate as an oil. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.38 (d, J=5.0 Hz, 1H), 6.91 (d, J=5.0 Hz, 1H), 3.85 (s, 3H), 2.55 (s, 3H); ESI-MS m/z 157 ([M+H]+).

References

[1] Patent: WO2012/56478, 2012, A1. Location in patent: Page/Page column 75-76
[2] Patent: WO2007/124546, 2007, A1. Location in patent: Page/Page column 58
[3] Patent: WO2014/64131, 2014, A2. Location in patent: Page/Page column 114; 115
[4] Patent: WO2014/76104, 2014, A1. Location in patent: Page/Page column 79-80
[5] Journal of Medicinal Chemistry, 1995, vol. 38, # 24, p. 4806 - 4820

METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Acetone Chromium(VI) oxide Methanol 3-Methyl-2-thiophenecarboxaldehyde Sulfuric acid

Preparation Products

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METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE Suppliers

Americas 1 China 120 Europe 1 Germany 3 India 4 Japan 1 United Kingdom 5 United States 15 Global 150
Manchester Organics
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Email
info@manchesterorganics.com
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United Kingdom
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6834
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67
CARBONE SCIENTIFIC CO.,LTD
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sales@carbonesci.com
Country
United Kingdom
ProdList
6666
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30
ETA SCIENTIFIC Co.,Ltd
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Email
sales@etascientific.com
Country
United Kingdom
ProdList
6090
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34
UK GREEN SCIENTIFIC CO.,LIMITED
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sales@gs-chem.com
Country
United Kingdom
ProdList
6098
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47
VWR International
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Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE 81452-54-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-26
Shanghai UCHEM Inc.
Product
Methyl 3-methylthiophene-2-carboxylate 81452-54-2
Price
US $47.00-679.00/g
Min. Order
25g
Purity
0.98
Supply Ability
25kg
Release date
2023-12-22
Shaanxi Dideu Medichem Co. Ltd
Product
3-methylthiophene-2-carboxylate 81452-54-2
Price
US $0.10-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-24

81452-54-2, METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATERelated Search:

DIETHYL 3,4-DIMETHYLTHIENO[2,3-B]THIOPHENE-2,5-DICARBOXYLATE DIETHYL 5-AMINO-3-METHYL-2,4-THIOPHENEDICARBOXYLATE METHYL 4-METHYLTHIOPHENE-2-CARBOXYLATE 3-Methylthiophene 3-Methyl-2-thiophenecarboxylic acid METHYL THIOPHENE-2-CARBOXYLATE 2-Thiophenecarboxylic acid 3-METHYLBENZO[B]THIOPHENE ETHYL 3-(BENZYLTHIO)-6,6-DIMETHYL-4-OXO-4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE-1-CARBOXYLATE ETHYL 3-(METHYLTHIO)-4-OXO-4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE-1-CARBOXYLATE ETHYL 5-CYANO-3,4-DIMETHYLTHIENO[2,3-B]THIOPHENE-2-CARBOXYLATE ETHYL 5-METHYL-3-(METHYLTHIO)-4,4-DIOXO-4,5-DIHYDRO-4LAMBDA6-BENZO[C]THIENO[3,4-E][1,2]THIAZINE-1-CARBOXYLATE METHYL 3-(5-FORMYL-2-FURYL)THIOPHENE-2-CARBOXYLATE ETHYL 3-(BUTYLTHIO)-4-OXO-4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE-1-CARBOXYLATE ETHYL 3-(ALLYLTHIO)-4-OXO-4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE-1-CARBOXYLATE ETHYL 4-ACETYL-3-METHYL-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE METHYL 4-[(4-CHLOROPHENYL)SULFONYL]-3-METHYLTHIOPHENE-2-CARBOXYLATE ETHYL 3-(BENZYLTHIO)-4-OXO-4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE-1-CARBOXYLATE

  • METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE
  • RARECHEM AL BF 0178
  • 3-Methylthiophene-2-carboxylic acid methyl ester
  • Methyl 3-methylthiophene-2-carboxylate ,99%
  • 3-Methylthiophene-2-Cabroxylate
  • Eethyl3-methylthiophene-2-carboxylate
  • 3-methylthiophene-2-carboxylate
  • 3-methyl-2-thiophenecarboxylic acid methyl ester
  • Methyl 3-Methylthiophene-2-carboxylate &gt
  • 2-Thiophenecarboxylic acid, 3-methyl-, methyl ester
  • METHYL 3-METHYLTHIOPHENE-2-CARBOXYLATE ISO 9001：2015 REACH
  • Methyl 3-methylthienyl-2-carboxylate
  • Methyl 3-methylthiophene-2-carboxylate , Methyl 3-methyl-thiophene-2-carboxylate
  • 3-Methylthiophen-2-carboxylic acid methyl ester
  • 81452-54-2