ChemicalBook > CAS DataBase List > 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER

2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER

Product Name
2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
CAS No.
4651-93-8
Chemical Name
2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
Synonyms
AKOS 92456;AKOS B000679;AKOS NCG-0059;ART-CHEM-BB B000679;SPECS AK-968/37166326;METHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE;METHYL 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLATE;2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLIC ACID METHYL ESTER;2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER;3-Thiophenecarboxylic acid, 2-amino-4,5-dimethyl-, methyl ester
CBNumber
CB2391373
Molecular Formula
C8H11NO2S
Formula Weight
185.24
MOL File
4651-93-8.mol
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2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Property

Melting point:
123-125 °C
Boiling point:
287.8±35.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
0.55±0.10(Predicted)
Appearance
Light yellow to yellow Solid
InChIKey
MZBOBUPJGXDOFT-UHFFFAOYSA-N
CAS DataBase Reference
4651-93-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
TMT00479
Product name
Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate
Packaging
1g
Price
$512
Updated
2023/01/07
TRC
Product number
M286628
Product name
Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
M286628
Product name
Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
028833
Product name
Methyl 2-amino-4,5-dimethylthiophene-3-carboxylate
Packaging
500mg
Price
$189
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020278
Product name
2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
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2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

78-93-3

105-34-0

4651-93-8

The general procedure for the synthesis of methyl 2-amino-3,5-dimethylthiophene-3-carboxylate from 2-butanone and methyl cyanoacetate was as follows: sulfur powder (160.0 mg, 5.0 mmol) was placed in a single-necked flask and 1.5 mL of DMF was added to dissolve it. Methyl cyanoacetate (495.4 mg, 5.0 mmol) and morpholine (435.6 mg, 5.0 mmol) were then added sequentially, and the reaction solution immediately changed to dark brown color. Then 2-butanone (901.4 mg, 12.5 mmol) was added and the reaction mixture was stirred at 50 °C overnight. After completion of the reaction, the mixture was cooled to room temperature, diluted with an appropriate amount of water and extracted three times with ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. Finally, the crude product was separated and purified by column chromatography to give a light yellow solid target compound in 40.7% yield.

References

[1] Patent: CN106167497, 2016, A. Location in patent: Paragraph 0414; 0415; 0416
[2] ChemMedChem, 2018,
[3] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 239 - 251

2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER Suppliers

China 41 Germany 3 India 1 Russia 2 Sweden 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 10 Global 67
Energy Chemical
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4651-93-8, 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTERRelated Search:

ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER DIETHYL 5-AMINO-3-METHYL-2,4-THIOPHENEDICARBOXYLATE 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER 5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER ethyl 5-acetyl-2-amino-4-methyl-thiophene-3-carboxylate ETHYL 2-ACETAMIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 2-AMINO-4-METHYL-5-PHENYLCARBAMOYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER ETHYL 2-[(2-CHLOROACETYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE AURORA 3766 BUTTPARK 128\48-16 ETHYL 2-((THIOXO((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-(((4-CHLOROPHENYL)AMINO)CARBONYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-(((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)CARBONYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-[2-(2,4-DICHLOROPHENOXY)ACETAMIDO]-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE AKOS 93369 BUTTPARK 123\48-20 AKOS 89941

  • SPECS AK-968/37166326
  • ART-CHEM-BB B000679
  • METHYL 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLATE
  • METHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE
  • 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
  • AKOS B000679
  • AKOS 92456
  • AKOS NCG-0059
  • 3-Thiophenecarboxylic acid, 2-amino-4,5-dimethyl-, methyl ester
  • 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLIC ACID METHYL ESTER
  • 2 - AMino-3, 5 - diMethyl-thiophene-3 - carboxylic acid Methyl ester
  • 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH
  • 4651-93-8
  • C8H11NO2S
  • Thiophene&Benzothiophene
  • Thiophene