YC-1
- Product Name
- YC-1
- CAS No.
- 170632-47-0
- Chemical Name
- YC-1
- Synonyms
- YC-1;CS-2261;Nsc728165;LIFICIGUAT;Lificiguat(YC-1);YC-1(Lificiguat);YC 1 (pharMaceutical);YC-1, guanylyl cyclase activator;YC-1 - CAS 170632-47-0 - Calbiochem;1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole
- CBNumber
- CB2395371
- Molecular Formula
- C19H16N2O2
- Formula Weight
- 304.34
- MOL File
- 170632-47-0.mol
YC-1 Property
- Melting point:
- 110-112℃
- Boiling point:
- 522.2±50.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: 12 mg/mL
- pka
- 13.83±0.10(Predicted)
- form
- solid
- color
- white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y102
- Product name
- YC-1
- Purity
- powder
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 688100
- Product name
- YC-1
- Packaging
- 5mg
- Price
- $219
- Updated
- 2023/01/07
- Product number
- 81560
- Product name
- YC-1
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $18
- Updated
- 2024/03/01
- Product number
- 81560
- Product name
- YC-1
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- Y102
- Product name
- YC-1
- Purity
- powder
- Packaging
- 25mg
- Price
- $804
- Updated
- 2024/03/01
YC-1 Chemical Properties,Usage,Production
Description
YC-1 (170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50?= 14.6 μM).1?Induces human endometrial cancer cell senescence via modulation of HIF1α activity.2?Induces degradation of HIF1α.3?Protects against glutamate-induced neuronal damage4?and β-amyloid-induced toxicity in differentiated PC12 cells5.
Uses
YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:
- to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
- to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
- to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.
Definition
ChEBI: Lificiguat is a member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation. It has a role as an antineoplastic agent, a soluble guanylate cyclase activator, an apoptosis inducer, a platelet aggregation inhibitor and a vasodilator agent. It is a member of indazoles, a member of furans and an aromatic primary alcohol.
General Description
A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.
Biochem/physiol Actions
YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.
storage
+4°C
References
1) Martin?et al.?(2001),?YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components;?Proc. Natl. Acad. Sci. USA,?98?12938 2) Kato?et al.?(2006),?Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1; Int. J. Cancer,?118?1144 3) Kim?et al.?(2006),?A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent; Int. J. Oncol.,?29?255 4) Tai?et al. (2018),?Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia; Mol. Med. Rep.,?17?6490 5) Tsai?et al.?(2013),?The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells.; PLoS One,?8(7)?e69320
YC-1 Preparation Products And Raw materials
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