4'-METHOXYVALEROPHENONE
- Product Name
- 4'-METHOXYVALEROPHENONE
- CAS No.
- 1671-76-7
- Chemical Name
- 4'-METHOXYVALEROPHENONE
- Synonyms
- p-Methoxyvalerophenon;P-METHOXYVALEROPHENONE;4-METHOXYVALEROPHENONE;4'-METHOXYVALEROPHENONE;4-Methoxy-1-phenylpentan-1-one;1-(4-Methoxyphenyl)-1-pentanone;1-(4-Methoxyphenyl)pentane-1-one;1-Pentanone, 1-(4-methoxyphenyl)-;1-(4-METHOXY-PHENYL)-PENTAN-1-ONE
- CBNumber
- CB2404543
- Molecular Formula
- C12H16O2
- Formula Weight
- 192.25
- MOL File
- 1671-76-7.mol
4'-METHOXYVALEROPHENONE Property
- Melting point:
- 22-23.5 °C
- Boiling point:
- 300 °C(Press: 739 Torr)
- Density
- 0.988±0.06 g/cm3(Predicted)
- CAS DataBase Reference
- 1671-76-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S369608
- Product name
- 4'-METHOXYVALEROPHENONE
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- M271778
- Product name
- 4''-Methoxyvalerophenone
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CHM0162778
- Product name
- 4'-METHOXYVALEROPHENONE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $726
- Updated
- 2021/12/16
- Product number
- K0331212
- Product name
- 1-(4-Methoxy-phenyl)-pentan-1-one
- Packaging
- 5g
- Price
- $1728
- Updated
- 2021/12/16
- Product number
- K0331212
- Product name
- 1-(4-Methoxy-phenyl)-pentan-1-one
- Packaging
- 1g
- Price
- $661
- Updated
- 2021/12/16
4'-METHOXYVALEROPHENONE Chemical Properties,Usage,Production
Preparation
To a solution of N-methoxy-N-methyl-2-pyridyl urethane (364.4 mg, 2 mmol) in THF (6 mL), p-methoxyphenylmagnesium bromide (0.25 m in THF, 8 mL, 2 mmol) was added dropwise over a period of 10 min at 0 °C under nitrogen atmosphere. Stirring was maintained for a further 5 min and then n-butyllithium (1.60 m in hexane, 1.5 mL, 2.4 mmol) was added directly to the mixture (one-pot process). The reaction mixture was stirred for 0.5 h, while warming to room temperature, and was then quenched with 1 n HCl (5 mL). After evaporation of the THF, the concentrated mixture was poured into 1 n HCl (30 mL) and the aqueous phase was extracted with dichloromethane (3*20 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated to dryness in vacuo. The crude product was purified by column chromatography on silica gel (EtOAc/n-hexane, 1:4) to give 369.1 mg (96%) of p-methoxyvalerophenone.
Preparation
To a solution of N-methoxy-Nmethyl- 2-pyridyl urethane (364.4 mg, 2 mmol) in THF (6 mL), p-methoxyphenylmagnesium bromide (0.25 m in THF, 8 mL, 2 mmol) was added dropwise over a period of 10 min at 0 ℃ under nitrogen atmosphere. Stirring was maintained for a further 5 min and then n-butyllithium (1.60 M in hexane, 1.5 mL, 2.4 mmol) was added directly to the mixture (one-pot process). The reaction mixture was stirred for 0.5 h, while warming to room temperature, and was then quenched with 1 N HCl (5 mL). After evaporation of the THF, the concentrated mixture was poured into 1 N HCl (30 mL) and the aqueous phase was extracted with dichloromethane (3×20 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated to dryness in vacuo. The crude product was purified by column chromatography on silica gel (EtOAc/n-hexane, 1:4) to give 369.1 mg (96%) of p-methoxyvalerophenone.
Synthesis Reference(s)
Chemistry Letters, 15, p. 165, 1986
Tetrahedron, 50, p. 11839, 1994 DOI: 10.1016/S0040-4020(01)89299-1
4'-METHOXYVALEROPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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