R-(+)-DIOA

Product Name: R-(+)-DIOA
CAS No.: 81166-47-4
Chemical Name: R-(+)-DIOA
Synonyms: R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor;Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-;R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
CBNumber: CB7506132
Molecular Formula: C20H24Cl2O4
Formula Weight: 399.31
MOL File: 81166-47-4.mol

More

Less

R-(+)-DIOA Property

Melting point:: 173-174 °C
Boiling point:: 562.2±50.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
solubility: H2O: insoluble <0.11mg/mL
form: solid
pka: 2.80±0.10(Predicted)
color: white
optical activity: [α]27/D +18.1°, c = 0.7 in methanol(lit.)
Water Solubility: H2O: insoluble <0.11mg/mL
DMSO: >20mg/mL
0.1 M HCl: insoluble
0.1 M NaOH: soluble
ethanol: soluble

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D129
Product name: R-(+)-DIOA
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $320
Updated: 2024/03/01

Sigma-Aldrich

Product number: D129
Product name: R-(+)-DIOA
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $624
Updated: 2024/03/01

TRC

Product number: D492360
Product name: R-(+)-DIOA
Packaging: 1mg
Price: $110
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0004079
Product name: R-(+)-DIOA
Purity: 95.00%
Packaging: 10MG
Price: $763.42
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0004079
Product name: R-(+)-DIOA
Purity: 95.00%
Packaging: 50MG
Price: $1456.52
Updated: 2021/12/16

More

Less

R-(+)-DIOA Chemical Properties,Usage,Production

Uses

R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.

Uses

R-(+)-DIOA has been used as a potassium/chloride K⁺-Cl^- transport inhibitor to study its effects on:

short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
uptake of grepafloxacin by THP-1 monocytes
the uptake of moxifloxacin by THP-1 monocytes

Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.

R-(+)-DIOA Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

R-(+)-DIOA Suppliers

China 5 Germany 1 Switzerland 1 United Kingdom 1 United States 4 Global 12

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 19699
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

81166-47-4, R-(+)-DIOARelated Search:

3-CHLORO-5-METHYLPHENOL 5-METHOXYINDAN 2-PROPYL-1-INDANONE, 98 3-METHYLPHENOXYACETIC ACID 3-CHLORO-4-METHOXYACETOPHENONE 2-CHLORO-5-METHYLPHENOL 3-Chlorophenoxyacetic acid 2,3-Dichlorophenol 4'-Hydroxyvalerophenone 2,3-DICHLOROANISOLE 3'-Chloropropiophenone 2-Chloro-4-hydroxybenzaldehyde 2,3-Dichloroacetophenone 3,4-DIMETHYLPHENOXYACETIC ACID 2-METHYL-1-INDANONE 5-Methoxy-1-indanone 2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE 2-(3-CHLOROPHENOXY)ETHANOL

R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid

Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-

R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor

81166-47-4

C20H24Cl2O4