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R-(+)-DIOA

Product Name
R-(+)-DIOA
CAS No.
81166-47-4
Chemical Name
R-(+)-DIOA
Synonyms
R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor;Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-;R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
CBNumber
CB7506132
Molecular Formula
C20H24Cl2O4
Formula Weight
399.31
MOL File
81166-47-4.mol
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R-(+)-DIOA Property

Melting point:
173-174 °C
Boiling point:
562.2±50.0 °C(Predicted)
Density 
1.307±0.06 g/cm3(Predicted)
solubility 
H2O: insoluble <0.11mg/mL
form 
solid
pka
2.80±0.10(Predicted)
color 
white
optical activity
[α]27/D +18.1°, c = 0.7 in methanol(lit.)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D129
Product name
R-(+)-DIOA
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$320
Updated
2024/03/01
Sigma-Aldrich
Product number
D129
Product name
R-(+)-DIOA
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$624
Updated
2024/03/01
TRC
Product number
D492360
Product name
R-(+)-DIOA
Packaging
1mg
Price
$110
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0004079
Product name
R-(+)-DIOA
Purity
95.00%
Packaging
10MG
Price
$763.42
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0004079
Product name
R-(+)-DIOA
Purity
95.00%
Packaging
50MG
Price
$1456.52
Updated
2021/12/16
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R-(+)-DIOA Chemical Properties,Usage,Production

Uses

R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.

Uses

R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:

  • short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
  • uptake of grepafloxacin by THP-1 monocytes
  • the uptake of moxifloxacin by THP-1 monocytes

Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.

R-(+)-DIOA Preparation Products And Raw materials

Raw materials

Preparation Products

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R-(+)-DIOA Suppliers

China 5 Germany 1 Switzerland 1 United Kingdom 1 United States 4 Global 12
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19704
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58

81166-47-4, R-(+)-DIOARelated Search:

3-CHLORO-5-METHYLPHENOL 5-METHOXYINDAN 2-PROPYL-1-INDANONE, 98 3-METHYLPHENOXYACETIC ACID 3-CHLORO-4-METHOXYACETOPHENONE 2-CHLORO-5-METHYLPHENOL 3-Chlorophenoxyacetic acid 2,3-Dichlorophenol 4'-Hydroxyvalerophenone 2,3-DICHLOROANISOLE 3'-Chloropropiophenone 2-Chloro-4-hydroxybenzaldehyde 2,3-Dichloroacetophenone 3,4-DIMETHYLPHENOXYACETIC ACID 2-METHYL-1-INDANONE 5-Methoxy-1-indanone 2,3-DIHYDRO-2,2-DIMETHYLINDEN-1-ONE 2-(3-CHLOROPHENOXY)ETHANOL

  • R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
  • Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-
  • R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor
  • 81166-47-4
  • C20H24Cl2O4