4'-Hydroxyvalerophenone

Product Name: 4'-Hydroxyvalerophenone
CAS No.: 2589-71-1
Chemical Name: 4'-Hydroxyvalerophenone
Synonyms: p-Valerylphenol;4-VALERYL-PHENOL;4-PENTANOYLPHENOL;4'- hydroxyketone;4-Hydroxyvaleropheno;4'-hydroxy-pentanone;Hydroxyvalerophenone;P-HYDROXYVALEROPHENONE;4-HYDROXYVALEROPHENONE;p-Hydroxypentanophenone
CBNumber: CB8203348
Molecular Formula: C11H14O2
Formula Weight: 178.23
MOL File: 2589-71-1.mol

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4'-Hydroxyvalerophenone Property

Melting point:: 62-65 °C
Boiling point:: 182-183 °C/3 mmHg(lit.)
Density: 1.0292 (rough estimate)
refractive index: 1.5390 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 8.13±0.15(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C11H14O2/c1-2-3-4-11(13)9-5-7-10(12)8-6-9/h5-8,12H,2-4H2,1H3
InChIKey: ZKCJJGOOPOIZTE-UHFFFAOYSA-N
SMILES: C(C1=CC=C(O)C=C1)(=O)CCCC
CAS DataBase Reference: 2589-71-1(CAS DataBase Reference)
NIST Chemistry Reference: 1-Pentanone, 1-(4-hydroxyphenyl)-(2589-71-1)
EPA Substance Registry System: 1-Pentanone, 1-(4-hydroxyphenyl)- (2589-71-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-37/39-26
WGK Germany: 3
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 245143
Product name: 4′-Hydroxyvalerophenone
Purity: 98%
Packaging: 25g
Price: $180
Updated: 2023/06/20

TCI Chemical

Product number: H0627
Product name: 4'-Hydroxyvalerophenone
Purity: >98.0%(T)
Packaging: 25g
Price: $118
Updated: 2025/07/31

TCI Chemical

Product number: H0627
Product name: 4'-Hydroxyvalerophenone
Purity: >98.0%(T)
Packaging: 500g
Price: $1092
Updated: 2025/07/31

TRC

Product number: H995618
Product name: 4''-Hydroxyvalerophenone
Packaging: 5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: F034
Product name: 4-Hydroxyvalerophenone
Packaging: 1g
Price: $16
Updated: 2021/12/16

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4'-Hydroxyvalerophenone Chemical Properties,Usage,Production

Chemical Properties

white to light beige powder

Uses

4'-Hydroxyvalerophenone is an organic intermediate and pharmaceutical intermediate for the preparation of acylphenoxyacetic acid compounds.

Preparation

4'-Hydroxyvalerophenone is synthesized from phenol and valeryl chloride. It is a raw material intermediate for liquid crystals.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6537, 1994 DOI: 10.1016/S0040-4039(00)78266-9

Synthesis

638-29-9

108-95-2

2589-71-1

GENERAL METHOD: Phenol (0.28 mmol) was dissolved in trifluoromethanesulfonic acid (TfOH, 3 mL) with n-pentanoyl chloride (0.28 mmol) at 0 °C. The reaction mixture was gradually warmed up to room temperature according to the conditions shown in Table 2 and kept for an appropriate time. After completion of the reaction, the mixture was poured into a mixture of ice water and ethyl acetate. The organic layer was separated and washed sequentially with 1 M hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated. The crude product was purified by silica gel column chromatography to give 4-hydroxyvalerophenone. The spectral data of all the products were in agreement with those reported in the literature.

References

[1] Tetrahedron, 2011, vol. 67, # 3, p. 641 - 649
[2] Chemische Berichte, 1985, vol. 118, # 8, p. 3332 - 3349
[3] Tetrahedron, 1981, vol. 37, # 16, p. 2815 - 2821
[4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1998, vol. 54, # 2, p. 285 - 297
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 6, p. 841 - 844

4'-Hydroxyvalerophenone Preparation Products And Raw materials

Raw materials

Phenol Aluminum chloride Nitrobenzene Valeryl chloride

Preparation Products

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4'-Hydroxyvalerophenone Suppliers

Americas 1 Canada 2 China 219 Europe 3 Germany 4 India 5 Japan 3 Singapore 1 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 8 United States 28 Global 277

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View Lastest Price from 4'-Hydroxyvalerophenone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4'-Hydroxyvalerophenone 2589-71-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4'-Hydroxyvalerophenone 2589-71-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

Henan Aochuang Chemical Co.,Ltd.

Product: 4'-Hydroxyvalerophenone 2589-71-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-18

2589-71-1, 4'-HydroxyvalerophenoneRelated Search:

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4′-Hydroxyvalerophenone, CAS 2589-71-1

2589-71-1

HOC6H4COCH23CH3

Ketones

Organic Building Blocks

KETONE

Building Blocks

C11 to C12

Carbonyl Compounds

C11 to C12

Carbonyl Compounds

Ketones

2589-71-1