4'-Hydroxyvalerophenone
- Product Name
- 4'-Hydroxyvalerophenone
- CAS No.
- 2589-71-1
- Chemical Name
- 4'-Hydroxyvalerophenone
- Synonyms
- p-Valerylphenol;4-VALERYL-PHENOL;4-PENTANOYLPHENOL;4'- hydroxyketone;4-Hydroxyvaleropheno;4'-hydroxy-pentanone;Hydroxyvalerophenone;P-HYDROXYVALEROPHENONE;4-HYDROXYVALEROPHENONE;p-Hydroxypentanophenone
- CBNumber
- CB8203348
- Molecular Formula
- C11H14O2
- Formula Weight
- 178.23
- MOL File
- 2589-71-1.mol
4'-Hydroxyvalerophenone Property
- Melting point:
- 62-65 °C
- Boiling point:
- 182-183 °C/3 mmHg(lit.)
- Density
- 1.0292 (rough estimate)
- refractive index
- 1.5390 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 8.13±0.15(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C11H14O2/c1-2-3-4-11(13)9-5-7-10(12)8-6-9/h5-8,12H,2-4H2,1H3
- InChIKey
- ZKCJJGOOPOIZTE-UHFFFAOYSA-N
- SMILES
- C(C1=CC=C(O)C=C1)(=O)CCCC
- CAS DataBase Reference
- 2589-71-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Pentanone, 1-(4-hydroxyphenyl)-(2589-71-1)
- EPA Substance Registry System
- 1-Pentanone, 1-(4-hydroxyphenyl)- (2589-71-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-37/39-26
- WGK Germany
- 3
- HS Code
- 29182900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 245143
- Product name
- 4′-Hydroxyvalerophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $180
- Updated
- 2023/06/20
- Product number
- H0627
- Product name
- 4'-Hydroxyvalerophenone
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- H0627
- Product name
- 4'-Hydroxyvalerophenone
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $1092
- Updated
- 2025/07/31
- Product number
- H995618
- Product name
- 4''-Hydroxyvalerophenone
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- JK235759
- Product name
- 4'-Hydroxyvalerophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
4'-Hydroxyvalerophenone Chemical Properties,Usage,Production
Chemical Properties
white to light beige powder
Uses
4'-Hydroxyvalerophenone is an organic intermediate and pharmaceutical intermediate for the preparation of acylphenoxyacetic acid compounds.
Preparation
4'-Hydroxyvalerophenone is synthesized from phenol and valeryl chloride. It is a raw material intermediate for liquid crystals.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 6537, 1994 DOI: 10.1016/S0040-4039(00)78266-9
Synthesis
638-29-9
108-95-2
2589-71-1
GENERAL METHOD: Phenol (0.28 mmol) was dissolved in trifluoromethanesulfonic acid (TfOH, 3 mL) with n-pentanoyl chloride (0.28 mmol) at 0 °C. The reaction mixture was gradually warmed up to room temperature according to the conditions shown in Table 2 and kept for an appropriate time. After completion of the reaction, the mixture was poured into a mixture of ice water and ethyl acetate. The organic layer was separated and washed sequentially with 1 M hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated. The crude product was purified by silica gel column chromatography to give 4-hydroxyvalerophenone. The spectral data of all the products were in agreement with those reported in the literature.
References
[1] Tetrahedron, 2011, vol. 67, # 3, p. 641 - 649
[2] Chemische Berichte, 1985, vol. 118, # 8, p. 3332 - 3349
[3] Tetrahedron, 1981, vol. 37, # 16, p. 2815 - 2821
[4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1998, vol. 54, # 2, p. 285 - 297
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 6, p. 841 - 844
4'-Hydroxyvalerophenone Preparation Products And Raw materials
Raw materials
Preparation Products
4'-Hydroxyvalerophenone Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
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View Lastest Price from 4'-Hydroxyvalerophenone manufacturers
- Product
- 4'-Hydroxyvalerophenone 2589-71-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-09
- Product
- 4'-Hydroxyvalerophenone 2589-71-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31
- Product
- 4'-Hydroxyvalerophenone 2589-71-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-18