ChemicalBook > CAS DataBase List > D(-)-Arginine

D(-)-Arginine

Product Name: D(-)-Arginine
CAS No.: 157-06-2
Chemical Name: D(-)-Arginine
Synonyms: D-ARGININE;H-D-ARG-OH;D-ARG;D-Arg-OH;D-Arginin;H-D-Arginine;ARGININE, D-;D-(-)-ARGININE;R-(-)-ARGININE;D-Arginine，98%
CBNumber: CB2408147
Molecular Formula: C6H14N4O2
Formula Weight: 174.2
MOL File: 157-06-2.mol

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D(-)-Arginine Property

Melting point:: 226 °C (dec.) (lit.)
alpha: -28.5 º (c=8, 6 N HCl)
Boiling point:: 305.18°C (rough estimate)
Density: 1.2297 (rough estimate)
refractive index: -23 ° (C=8, 6mol/L HCl)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Aqueous Acid (Slightly), Water (Slightly)
form: Solid
pka: 2.49±0.24(Predicted)
color: White to Off-White
Water Solubility: SOLUBLE
Sensitive: Air Sensitive
BRN: 1725412
InChIKey: ODKSFYDXXFIFQN-SCSAIBSYSA-N
LogP: -0.999 (est)
CAS DataBase Reference: 157-06-2(CAS DataBase Reference)
EPA Substance Registry System: D-Arginine (157-06-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36-36/37/38-20/21/22
Safety Statements: 26-36
WGK Germany: 3
RTECS: CF1934220
F: 9
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29252000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A2646
Product name: D-Arginine
Purity: ≥98% (TLC)
Packaging: 1g
Price: $114
Updated: 2025/07/31

Sigma-Aldrich

Product number: A2646
Product name: D-Arginine
Purity: ≥98% (TLC)
Packaging: 5g
Price: $355.02
Updated: 2025/07/31

TCI Chemical

Product number: A1029
Product name: D-(-)-Arginine
Purity: >98.0%(T)
Packaging: 1g
Price: $57
Updated: 2025/07/31

TCI Chemical

Product number: A1029
Product name: D-(-)-Arginine
Purity: >98.0%(T)
Packaging: 5g
Price: $196
Updated: 2025/07/31

Sigma-Aldrich

Product number: A2646
Product name: D-Arginine
Purity: ≥98% (TLC)
Packaging: 250mg
Price: $38.67
Updated: 2025/07/31

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D(-)-Arginine Chemical Properties,Usage,Production

Description

D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.

Chemical Properties

white to light yellow crystal powde

Uses

Arginine is an essential amino acid found in food and plant sources, and many biological systems.
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man.
D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.

Uses

1-Deamino-8-D-arginine vasopressin makes a new pharmacological approach to the management of haemophilia and von Willebrand's disease. A novel nonenzymatic pathway for the generation of nitric oxide is by the reaction of hydrogen peroxide and d- or l-arginine.

Definition

ChEBI: D-arginine is a D-alpha-amino acid that is the D-isomer of arginine. It has a role as an EC 4.1.1.19 (arginine decarboxylase) inhibitor and a mouse metabolite. It is a D-alpha-amino acid and an arginine. It is a conjugate base of a D-argininium(1+). It is a conjugate acid of a D-argininate. It is an enantiomer of a L-arginine.

in vivo

D-arginine (1 mg/kg, i.v., caudal veins, every two days) sensitize osteosarcoma to radiotherapy in a mouse model of subcutaneous osteosarcoma^[3].
The number of D-arginine residues in cell-penetrating peptides (i.v.) significantly affects their cellular uptake behavior and systemic toxicity in mice^[4].
D-Arginine (700 mg/kg, i.p.) displays central stimulant properties and increases spontaneous motor activity in mice^[5].
D-arginine (i.p.) shows a light toxicity order (LD50: 2800 mg/kg) in mice^[5].
D-arginine (1400 mg/kg, i.p.) protects against Pentylenetetrazole-induced convulsions in mice^[5].
D-arginine (1000 mg/kg, p.o., 16 weeks) significantly alters various enzymes and metabolites in the arginine metabolic pathways in male SD rats^[6].
D-arginine (1000 mg/kg, s.c., coadministered with L-arginine) blocks antinociception elicited by L-arginine (HY-N0455) in mice with Carrageenin-induced hyperalgesia^[7].
D-arginine (20 mg/kg, s.c.) does not significantly alter the percentage of antinociception in mice^[8].

Animal Model:	Female BALB/c mice (anesthetized by intraperitoneal injection of 3% pentobarbital sodium; K7M2 cells were injected subcutaneously; X-ray irradiation)^[2]
Dosage:	1 mg/kg
Administration:	Intravenous injection (i.v.), caudal veins, every two days
Result:	Inhibited tumor volume (20 days).

IC 50

Human Endogenous Metabolite

References

https://www.alfa.com/zh-cn/catalog/A16137/
Iannucci, N. B., et al. "Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells." Future Medicinal Chemistry 3.16(2011):1987-1993.
Ripoll, Giselle, et al. "Angiostatic activity of 1-Deamino-8-D-Arginine vasopressin and novel peptide analogues in breast cancer cells." Cancer Research 68(2008).
Navarro, Eduardo, et al. "Toxicological and Pharmacological Effects of D-Arginine." Basic & Clinical Pharmacology & Toxicology97.3(2005):149-154.

D(-)-Arginine Preparation Products And Raw materials

Raw materials

O-methylisourea D-Ornithine monohydrochloride

Preparation Products

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View Lastest Price from D(-)-Arginine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: D(-)-Arginine 157-06-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 500kg
Release date: 2025-07-18

R&D Scientific Inc.

Product: L-Arginine 157-06-2
Price: US $750.00/g
Min. Order: 1g
Purity: 99 %
Supply Ability: 5000 Kg
Release date: 2025-05-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: D(-)-Arginine 157-06-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-03

157-06-2, D(-)-ArginineRelated Search:

L(+)-Arginine EPA Guanidineacetic acid Glycine 3-Guanidinopropionic acid ARGINASE 6-Aminocaproic acid ALTRENOGEST 5-Amino-2-methylpyridine D-Lysine H-D-CIT-OH D-Ornithine monohydrochloride D-Ribose Arginine arginine aspirin BOC-D-Arg(Tos)-OH D-(-)-Arginine hydrochloride N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine

(2R)-2-ammonio-5-(diaminomethylideneammonio)pentanoate

R-(-)-ARGININE

(R)-2-AMINO-5-GUANIDINOPENTANOIC ACID

RARECHEM AB PP 1748

D-ARG

D-(-)-ARGININE

D-ARGININE

D-2-AMINO-5-GUANIDINOVALERIC ACID

H-D-Arginine

(-)-D-arginine hydrate

D-ARGININE FREE BASE

d-2-amino-5-guanidinopentanoic acid

(2R)-2-amino-5-(diaminomethylideneamino)pentanoic acid

ARGININE, D-(RG)

ARGININE, D-

H-D-ARG-OH

D-ARG.FREE BASE

D-ARGININE BASE

(2R)-2-Amino-5-(diaminomethylideneamino)pentanoic acid hydrate

D-Arginine ,99%

D-Arginine,(R)-2-Amino-5-guanidinopentanoic acid

D-GuanidineaMinovaleric acid

D-α-AMino-δ-guanidovaleric acid

D-Arg-OH

H-D-Arg-OH (R)-2-Amino-5-guanidinopentanoic acid D-2-Amino-5-guanidinovaleric acid

D-Arginine,99%e.e.

(2R)-2-amino-5-carbamimidamidopentanoic acid

D-Arginin

Arginine Impurity 5（D-Arginine）

D-(-)-Arginine &gt

D-Arginine, 99%, reagent grade

D-Arginine，98%

D(-)-Arginine USP/EP/BP

D- arginine base USP/EP/BP

dextro-arginine

TIANFU-CHEM D(-)-Arginine

D-Arginine (free base) extrapure CHR, 99%

(2R)-2-amino-5-guanidino-pentanoic acid

<sc>D</sc>-Arginine

157-06-2

C6H14N4O2

for Resolution of Acids

Optical Resolution

Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

amino

Amino Acids

Arginine [Arg, R]

Amino Acids and Derivatives

alpha-Amino Acids

Amino Acids

Biochemistry

for Resolution of Acids

Optical Resolution

Synthetic Organic Chemistry

PROTECTED AMINO ACID & PEPTIDES

Amino Acids Derivatives