Ethyl 4-Hydroxyhydrocinnamate

Product Name: Ethyl 4-Hydroxyhydrocinnamate
CAS No.: 23795-02-0
Chemical Name: Ethyl 4-Hydroxyhydrocinnamate
Synonyms: Landiolol Impurity 76;ETHYL P-HYDROXYHYDROCINNAMATE;ethyl 4-hydroxyhydrocinnamate;Ethyl p-hydroxyphenylpropionate;ETHYL 3-(4-HYDROXYPHENYL)PROPANOATE;Ethyl 3-(4-hydroxyphenyl)propionate;Ethyl 3-(4-hydroxyphenyl)propanoate 95%;Ethyl 4-Hydroxyhydrocinnamate USP/EP/BP;Ethyl 3-(4-hydroxyphenyl)propanoate, 95+%;3-(4-hydroxyphenyl)propanoic acid ethyl ester
CBNumber: CB2408824
Molecular Formula: C11H14O3
Formula Weight: 194.23
MOL File: 23795-02-0.mol

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Ethyl 4-Hydroxyhydrocinnamate Property

Melting point:: 40 °C
Boiling point:: 140 °C(Press: 0.2 Torr)
Density: 1.108
storage temp.: Inert atmosphere,Room Temperature
form: low melting solid / colourless liquid
pka: 9.99±0.15(Predicted)
color: White
CAS DataBase Reference: 23795-02-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
Hazard Note: Irritant
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S582131
Product name: ETHYL 4-HYDROXYHYDROCINNAMATE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S582131
Product name: ETHYL 4-HYDROXYHYDROCINNAMATE
Purity: Aldrich
Packaging: 250mg
Price: $179
Updated: 2024/03/01

TRC

Product number: E937185
Product name: Ethyl3-(4-Hydroxyphenyl)propanoate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: M403
Product name: ETHYL 4-HYDROXYHYDROCINNAMATE
Packaging: 10g
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2729-1-X3
Product name: Ethyl 3-(4-hydroxyphenyl)propanoate
Purity: 95%
Packaging: 5G
Price: $77
Updated: 2021/12/16

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Ethyl 4-Hydroxyhydrocinnamate Chemical Properties,Usage,Production

Synthesis

64-17-5

501-97-3

23795-02-0

GENERAL METHODS: Ethanol (1.0 mL) was added to a suspension of 3-(4-hydroxyphenyl)propanoic acid (0.05 mmol) and trimethylchlorosilane (TMCS, 0.1 mmol), and the reaction mixture was stirred at 25 °C for 24 h. The reaction was completed by evaporation of the solvent. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure to afford ethyl 3-(4-hydroxyphenyl)propionate (1b) in quantitative yield without further purification. The product was an oil; 1H NMR (400 MHz, CDCl3): δ 1.13 (3H, m, CH3), 2.82 (2H, m, CH2), 2.88 (2H, m, CH2), 4.00 (2H, m, OCH2), 6.75 (2H, m, Ph-H), 7.06 (2H, m, Ph-H); 13C NMR (50 MHz, CDCl3): δ 14.20 (CH3), 30.12 (CH2), 35.10 (CH2), 60.10 (CH2), 115.45 (2CH), 129.48 (2CH), 131.75 (C), 155.43 (C), 172.10 (CO); MS (EI): m/z 266; elemental analysis: Calculated values C, 68.02; H, 7.27; O, 24.71, measured values C, 68.0; H, 7.26; O, 24.68.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5345 - 5351
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 7, p. 1495 - 1503
[3] Tetrahedron Letters, 2010, vol. 51, # 44, p. 5753 - 5756
[4] Molecules, 2018, vol. 23, # 2,
[5] Patent: US2010/298422, 2010, A1. Location in patent: Page/Page column 18

Ethyl 4-Hydroxyhydrocinnamate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4-Hydroxyhydrocinnamate Suppliers

Belgium 1 China 96 Germany 3 India 2 Switzerland 1 United Kingdom 5 United States 14 Global 122

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23795-02-0, Ethyl 4-HydroxyhydrocinnamateRelated Search:

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Ethyl p-hydroxyphenylpropionate

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ETHYL 3-(4-HYDROXYPHENYL)PROPANOATE

ethyl 4-hydroxyhydrocinnamate

ETHYL P-HYDROXYHYDROCINNAMATE

3-(4-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Ethyl 3-(4-hydroxyphenyl)propanoate, 95+%

Ethyl 3-(4-hydroxyphenyl)propanoate 95%

Ethyl 3-(4-hydroxyphenyl)propionate

3-(4-hydroxyphenyl)propanoic acid ethyl ester

Benzenepropanoic acid, 4-hydroxy-, ethyl ester

Ethyl 4-Hydroxyhydrocinnamate USP/EP/BP

Landiolol Impurity 76

23795-02-0

Aromatic Cinnamic Acids, Esters and Derivatives