ChemicalBook > CAS DataBase List > 4-PHENYL-PYRIDIN-2-YLAMINE

4-PHENYL-PYRIDIN-2-YLAMINE

Product Name: 4-PHENYL-PYRIDIN-2-YLAMINE
CAS No.: 60781-83-1
Chemical Name: 4-PHENYL-PYRIDIN-2-YLAMINE
Synonyms: 4-phenyl-;4-phenyl-2-pyridinamin;4-Phenyl-2-pyridinamine;4-phenylpyridin-2-amine;2-AMINO-4-PHENYLPYRIDINE;4-phenyl-2-aminopyridine;4-Phenylpyridine-2-amine;2-Pyridinamine, 4-phenyl-;4-PHENYL-PYRIDIN-2-YLAMINE
CBNumber: CB2415301
Molecular Formula: C11H10N2
Formula Weight: 170.21
MOL File: 60781-83-1.mol

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4-PHENYL-PYRIDIN-2-YLAMINE Property

Melting point:: 164-165 °C(Solv: benzene (71-43-2))
Boiling point:: 343.7±30.0 °C(Predicted)
Density: 1.133±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: 6.63±0.11(Predicted)
color: Yellow
EPA Substance Registry System: 2-Amino-4-phenylpyridine (60781-83-1)

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Safety

Risk Statements: 41
Safety Statements: 26-39
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P399415
Product name: 4-Phenylpyridin-2-amine
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Apolloscientific

Product number: OR929662
Product name: 2-Amino-4-phenylpyridine
Purity: 95%
Packaging: 1g
Price: $92
Updated: 2021/12/16

AK Scientific

Product number: J50978
Product name: 2-Amino-4-phenylpyridine
Packaging: 1g
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-PQ
Product name: 2-Amino-4-phenylpyridine
Purity: 98%
Packaging: 1g
Price: $148
Updated: 2021/12/16

Apolloscientific

Product number: OR929662
Product name: 2-Amino-4-phenylpyridine
Purity: 95%
Packaging: 5g
Price: $372
Updated: 2021/12/16

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4-PHENYL-PYRIDIN-2-YLAMINE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 21, p. 874, 1978 DOI: 10.1021/jm00207a007
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

84249-14-9

98-80-6

60781-83-1

General procedure for the synthesis of 2-amino-4-phenylpyridine from 2-amino-4-bromopyridine and phenylboronic acid: phenylboronic acid (141 mg, 1.156 mmol), 4-bromo-2-amino-pyridine (200 mg, 1.156 mmol) and PdCl2(dppf)-CH2Cl2 adduct (94 mg, 0.116 mmol) were suspended in a mixture of 1,2 -dimethoxyethane (3 mL) and 1 M aqueous sodium carbonate (3.47 mL, 3.47 mmol) in a mixed solvent. The reaction mixture was stirred at 90 °C for 5 h and subsequently cooled to room temperature. The reaction mixture was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (DCM). The filtrate was concentrated under reduced pressure to remove the solvent, and the resulting crude product was purified by silica gel column chromatography (Biotage 40M column) using 0-10% methanol/dichloromethane gradient elution to afford the target product 2-amino-4-phenylpyridine (195 mg, 1.146 mmol, 99% yield). The product structure was confirmed by 1H NMR (400 MHz, CDCl3) and UPLC-MS: 1H NMR δ 4.49 (dd, 2H), 6.69-6.78 (m, 1H), 6.90 (dd, 1H), 7.39-7.52 (m, 3H), 7.56-7.68 (m, 2H), 8.10-8.17 (m, 1H); UPLC-MS: tR = 0.42 min, m/z = 171 [M + H]+.

References

[1] Patent: US2009/203705, 2009, A1. Location in patent: Page/Page column 49
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 24, p. 11171 - 11181
[3] Patent: WO2017/141036, 2017, A1. Location in patent: Page/Page column 50

4-PHENYL-PYRIDIN-2-YLAMINE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Ethyl acetate Hydrochloric acid 5-Ethyl-2-methylpyridine Dichloromethane Methanol PETROLEUM ETHER Sodium amide

Preparation Products

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View Lastest Price from 4-PHENYL-PYRIDIN-2-YLAMINE manufacturers

Career Henan Chemical Co

Product: 4-PHENYL-PYRIDIN-2-YLAMINE 60781-83-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-02-01

60781-83-1, 4-PHENYL-PYRIDIN-2-YLAMINERelated Search:

4-PHENYL-PYRIDIN-2-YLAMINE 5-PHENYL-PYRIDIN-2-YLAMINE 2-PHENYL-PYRIDIN-3-YLAMINE 6-PHENYL-PYRIDIN-2-YLAMINE 2-(4-METHOXY-PHENYL)-PYRIDIN-3-YLAMINE 3-PHENYL-PYRIDIN-2-YLAMINE 4-PHENYL-PYRIDIN-3-YLAMINE 4-Phenylpyridine 2-AMINO-4-(2-CHLOROPHENYL)-6-ISOBUTYLNICOTINONITRILE 2-AMINO-4-(3-CHLOROPHENYL)-6-(4-METHOXYPHENYL)NICOTINONITRILE 2-AMINO-4-(4-CHLOROPHENYL)-5,6-DIMETHYLNICOTINONITRILE 2-AMINO-4-(4-CHLOROPHENYL)-5-METHYL-6-PHENYLNICOTINONITRILE 2-PHENYL-PYRIDIN-3-YLAMINE HYDROCHLORIDE 5-PHENYL-PYRIDIN-3-YLAMINE 6-PHENYL-PYRIDIN-3-YLAMINE 3-BROMO-5-PHENYL-PYRIDIN-2-YLAMINE 4-PHENYL-PYRIDIN-3-YLAMINE DIHYDROCHLORIDE 2-PHENYL-PYRIDIN-4-YLAMINE

4-PHENYL-PYRIDIN-2-YLAMINE

2-AMINO-4-PHENYLPYRIDINE

4-phenyl-2-pyridinamin

4-phenylpyridin-2-amine

4-phenyl-

4-phenyl-2-aminopyridine

4-Phenyl-2-pyridinamine

4-Phenylpyridine-2-amine

2-Pyridinamine, 4-phenyl-

60781-83-1

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