5-CHLORO-2-METHOXYNICOTINIC ACID
- Product Name
- 5-CHLORO-2-METHOXYNICOTINIC ACID
- CAS No.
- 54916-65-3
- Chemical Name
- 5-CHLORO-2-METHOXYNICOTINIC ACID
- Synonyms
- 5-Chloro-2-methoxynicotinicaci;5-CHLORO-2-METHOXYNICOTINIC ACID;5-Chloro-2-methoxynicotinic acid 98%;5-Chloro-2-methoxypyridine-3-carboxylic acid;5-chloro-2-methoxy-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 5-chloro-2-methoxy-;5-Chloro-2-methoxypyridine-3-carboxylic acid, 3-Carboxy-5-chloro-2-methoxypyridine
- CBNumber
- CB2424680
- Molecular Formula
- C7H6ClNO3
- Formula Weight
- 187.58
- MOL File
- 54916-65-3.mol
5-CHLORO-2-METHOXYNICOTINIC ACID Property
- Melting point:
- 146-148°
- Boiling point:
- 301.3±37.0 °C(Predicted)
- Density
- 1.43
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.99±0.10(Predicted)
- form
- solid
- color
- White
- InChI
- InChI=1S/C7H6ClNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3H,1H3,(H,10,11)
- InChIKey
- DPIJNAABZCWXFD-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=C(Cl)C=C1C(O)=O
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- ADE000181
- Product name
- 5-Chloro-2-methoxynicotinic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $330
- Updated
- 2025/07/31
- Product number
- C428213
- Product name
- 5-Chloro-2-methoxynicotinic acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C428213
- Product name
- 5-Chloro-2-methoxynicotinic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 046278
- Product name
- 5-Chloro-2-methoxynicotinic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 046278
- Product name
- 5-Chloro-2-methoxynicotinic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
5-CHLORO-2-METHOXYNICOTINIC ACID Chemical Properties,Usage,Production
Synthesis
16498-81-0
54916-65-3
The general procedure for synthesizing 5-chloro-2-methoxynicotinic acid from 2-methoxynicotinic acid is as follows: Example 1: A. A 306 mg (0.002 mol) sample of 2-methoxynicotinic acid (product of Preparation A) was taken and added in a single addition to 20 mL of a well-stirred aqueous 5.25% sodium hypochlorite solution (Clorox). The resulting mixture (now in solution) was stirred for about 18 hours (i.e., overnight) at room temperature (about 20°C). Upon completion of the reaction, the reaction mixture was acidified with 10 mL of 1N hydrochloric acid and the resulting precipitate was subsequently extracted with chloroform. The organic extracts were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated in vacuo to give 195 mg (52% yield) of pure 5-chloro-2-methoxynicotinic acid with a melting point of 139-141 °C (melting points of 149-150 °C have been reported in the literature, based on D.E. Kuhla et al. in U.S. Patent No. 3,879,403). The pure product was further characterized by NMR data and mass spectrometry.
References
[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 1859 - 1865
[2] Synthetic Communications, 1989, vol. 19, # 9-10, p. 1505 - 1508
[3] Patent: US4980357, 1990, A
[4] Patent: US4716231, 1987, A
[5] Patent: EP306251, 1990, A3
5-CHLORO-2-METHOXYNICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLORO-2-METHOXYNICOTINIC ACID manufacturers
- Product
- 5-CHLORO-2-METHOXYNICOTINIC ACID 54916-65-3
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-03