METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE
- Product Name
- METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE
- CAS No.
- 208465-72-9
- Chemical Name
- METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE
- Synonyms
- METHYL 2-CHLOROMETHYL-4-OXAZOLECARBOXYLATE;METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE;METHYL 2-(CHLROMETHYL)-1,3-OXAZOLE-4-CARBOXYLATE;2-(Chloromethyl)-4-(methoxycarbonyl)-1,3-oxazole;METHYL 2-(CHLOROMETHYL)-1,3-OXAZOLE-4-CARBOXYLATE;Methyl2-(chloromethyl)-1,3-oxazole-4-carboxylate97%;2-CHLOROMETHYL-OXAZOLE-4-CARBOXYLIC ACID METHYL ESTER;Methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate 97%;Methyl (2-Chloromethyl)Oxazole-4-Carboxylate(WX630102);4-Oxazolecarboxylic acid, 2-(chloroMethyl)-, Methyl ester
- CBNumber
- CB2425465
- Molecular Formula
- C6H6ClNO3
- Formula Weight
- 175.57
- MOL File
- 208465-72-9.mol
METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE Property
- Melting point:
- 74 °C
- Boiling point:
- 230℃
- Density
- 1.339
- Flash point:
- 93℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -2.41±0.10(Predicted)
- color
- Off-white
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 22-26-36/37/39-45
- Hazard Note
- Corrosive
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- M218855
- Product name
- Methyl2-(Chloromethyl)oxazole-4-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- M11416
- Product name
- Methyl(2-chloromethyl)oxazole-4-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4H23-5-Z3
- Product name
- Methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 069431
- Product name
- Methyl (2-chloromethyl)oxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 500mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- Y8207
- Product name
- Methyl2-(chloromethyl)oxazole-4-carboxylate
- Packaging
- 1g
- Price
- $177
- Updated
- 2021/12/16
METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
3018-12-0
5680-80-8
208465-72-9
GENERAL STEPS: Sodium methanolate (25.00 mg, 0.46 mmol) was dissolved in anhydrous methanol (4.50 mL) and dry dichloromethane (30.00 mL) under nitrogen protection and cooled to 0 °C. Dichloroacetonitrile (5.00 g, 45.50 mmol) was slowly added to this stirred solution and stirring was continued for 1 hour at 0°C. Subsequently, L-serine methyl ester hydrochloride (7.00 g, 45.50 mmol) was added and the reaction mixture was warmed to 25 °C and stirred for 12 hours. Upon completion of the reaction, water was added and the aqueous phase was extracted with dichloromethane (3 x 25.00 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was dissolved in dichloromethane (50.00 mL) and N,N-diisopropylethylamine (11.90 mL, 68.30 mmol) was added. The reaction mixture was stirred at 50 °C for 5 hours, followed by continued stirring at 25 °C for 12 hours. At the end of the reaction, water was added and the aqueous phase was extracted with dichloromethane (3 x 25.00 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The product did not require further purification (quantitative yield).ESI-MS m/z: 176 [M + H]+, 198 [M + Na]+; 1H NMR (300 MHz, CDCl3) δ 3.92 (s, 3H), 4.63 (s, 2H), 8.25 (s, 1H).
References
[1] Tetrahedron Letters, 2016, vol. 57, # 8, p. 920 - 923
METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE manufacturers
- Product
- METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE 208465-72-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23