ChemicalBook > CAS DataBase List > N-Boc-N-methyl glycine methyl ester

N-Boc-N-methyl glycine methyl ester

Product Name: N-Boc-N-methyl glycine methyl ester
CAS No.: 42492-57-9
Chemical Name: N-Boc-N-methyl glycine methyl ester
Synonyms: BOC-GLY-OME;Boc-Sar-Ome-OH;JACS-42492-57-9;BOC-GLY-OME (42492-57-9);BOC-SARCOSINE METHYL ESTER;N-Boc-sarcosinemethylester,97%;N-Boc-sarcosine Methyl ester, 97%;Methyl 2-[Boc(methyl)amino]acetate;N-Boc-N-methyl glycine methyl ester;METHYL 2-[(TERT-BUTOXYCARBONYL)AMINO]ACETATE
CBNumber: CB2425566
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 42492-57-9.mol

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N-Boc-N-methyl glycine methyl ester Property

Boiling point:: 249.6±19.0 °C(Predicted)
Density: 1.062±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.88±0.70(Predicted)
form: Liquid
color: Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B810313
Product name: N-Boc-sarcosineMethylEster
Packaging: 1g
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002869
Product name: BOC-SAR-OME
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002869
Product name: BOC-SAR-OME
Purity: 95.00%
Packaging: 1G
Price: $183.75
Updated: 2021/12/16

Activate Scientific

Product number: AS49132
Product name: Methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
Purity: 95%
Packaging: 25g
Price: $234
Updated: 2021/12/16

AK Scientific

Product number: 0873CV
Product name: Methyl2-((tert-butoxycarbonyl)(methyl)amino)acetate
Packaging: 25g
Price: $297
Updated: 2021/12/16

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N-Boc-N-methyl glycine methyl ester Chemical Properties,Usage,Production

Chemical Properties

Light yellow or colorless transparent liquid

Uses

N-Boc-sarcosine methyl ester is involved in the preparation of N-[(R, R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl) carbamoyl] allyl-N-methyl-3, 5-bis(trifluoromethyl) benzamides.

Synthesis

24424-99-5

13515-93-0

42492-57-9

Thionyl chloride (29.02 mL, 0.40 mol) was slowly added dropwise to a suspension of sarcosine methyl ester hydrochloride (35.64 g, 0.40 mol) in 350 mL of methanol at 0 °C. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 30 minutes followed by reflux for 6 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was dried overnight under high vacuum to afford sarcosine methyl ester hydrochloride in the form of a white powder, which could be used in the next step of the reaction without further purification. Yield: 56.14 g (quantitative); Melting point: 102°C. NMR hydrogen spectrum (300 MHz, CDCl3): δ=9.76 (s, 2H, NH2), 3.88 (t, J=5.6 Hz, 2H, CH2), 3.82 (s, 3H, OCH3), 2.83 (t, J=5.2 Hz, 3H, NCH3). NMR carbon spectrum (75MHz, CDCl3): δ=166.7 (C=O), 53.3 (CH2), 48.9 (NCH3), 33.4 (OCH3). Sarcosine methyl ester hydrochloride (59.80 g, 0.43 mol) was suspended in 1.0 L of dichloromethane, and a mixture of triethylamine (119.09 mL, 0.86 mol) and di-tert-butyl dicarbonate (138.01 mL, 0.65 mol) was added slowly and dropwise at 0 °C. After dropwise addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 2 days. After completion of the reaction, the reaction was adjusted to pH=6 by adding 1 M aqueous hydrochloric acid, the organic layer was separated, washed with distilled water, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and volatile impurities were removed overnight under high vacuum to give the clarified oily product methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate. Yield: 78.65 g (90%).

References

[1] Synthesis (Germany), 2017, vol. 49, # 4, p. 770 - 774
[2] Patent: EP1032561, 2004, B1. Location in patent: Page 21

N-Boc-N-methyl glycine methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-N-methyl glycine methyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Sar-Ome 42492-57-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-27

Henan Aochuang Chemical Co.,Ltd.

Product: N-Boc-N-methyl glycine methyl ester 42492-57-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Hebei Chuanghai Biotechnology Co,.LTD

Product: N-Boc-N-methyl glycine methyl ester 42492-57-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

42492-57-9, N-Boc-N-methyl glycine methyl esterRelated Search:

BOC-GLYCINE METHYL ESTER BOC-Glycine

BOC-SARCOSINE METHYL ESTER

BOC-GLY-OME

N-tert-Butoxycarbonylsarcosine methyl ester

N-Boc-sarcosine Methyl ester, 97%

N-Boc-N-methyl glycine methyl ester

Methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate

N-ALPHA-T-BUTOXYCARBONYL-GLYCINE METHYL ESTER

METHYL 2-[(TERT-BUTOXYCARBONYL)AMINO]ACETATE

JACS-42492-57-9

Glycine,N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, methyl ester

N-Boc-sarcosinemethylester,97%

methyl N-(tert-butoxycarbonyl)-N-methylglycinate

BOC-GLY-OME (42492-57-9)

N-Boc-N-methyl glycine methyl ester USP/EP/BP

Boc-Sar-Ome-OH

Methyl 2-[Boc(methyl)amino]acetate

42492-57-9

Peptide Synthesis

Specialty Synthesis

Amino Acid Derivatives