N-Boc-N-methyl glycine methyl ester
- Product Name
- N-Boc-N-methyl glycine methyl ester
- CAS No.
- 42492-57-9
- Chemical Name
- N-Boc-N-methyl glycine methyl ester
- Synonyms
- BOC-GLY-OME;Boc-Sar-Ome-OH;JACS-42492-57-9;BOC-GLY-OME (42492-57-9);BOC-SARCOSINE METHYL ESTER;N-Boc-sarcosinemethylester,97%;N-Boc-sarcosine Methyl ester, 97%;Methyl 2-[Boc(methyl)amino]acetate;N-Boc-N-methyl glycine methyl ester;METHYL 2-[(TERT-BUTOXYCARBONYL)AMINO]ACETATE
- CBNumber
- CB2425566
- Molecular Formula
- C9H17NO4
- Formula Weight
- 203.24
- MOL File
- 42492-57-9.mol
N-Boc-N-methyl glycine methyl ester Property
- Boiling point:
- 249.6±19.0 °C(Predicted)
- Density
- 1.062±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.88±0.70(Predicted)
- form
- Liquid
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B810313
- Product name
- N-Boc-sarcosineMethylEster
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- AS49132
- Product name
- Methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
- Purity
- 95%
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- AS49132
- Product name
- Methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
- Purity
- 95%
- Packaging
- 5G
- Price
- $69
- Updated
- 2021/12/16
- Product number
- AAA0002869
- Product name
- BOC-SAR-OME
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $183.75
- Updated
- 2021/12/16
- Product number
- AS49132
- Product name
- Methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
- Purity
- 95%
- Packaging
- 25g
- Price
- $234
- Updated
- 2021/12/16
N-Boc-N-methyl glycine methyl ester Chemical Properties,Usage,Production
Chemical Properties
Light yellow or colorless transparent liquid
Uses
N-Boc-sarcosine methyl ester is involved in the preparation of N-[(R, R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl) carbamoyl] allyl-N-methyl-3, 5-bis(trifluoromethyl) benzamides.
Synthesis
24424-99-5
13515-93-0
42492-57-9
Thionyl chloride (29.02 mL, 0.40 mol) was slowly added dropwise to a suspension of sarcosine methyl ester hydrochloride (35.64 g, 0.40 mol) in 350 mL of methanol at 0 °C. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 30 minutes followed by reflux for 6 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was dried overnight under high vacuum to afford sarcosine methyl ester hydrochloride in the form of a white powder, which could be used in the next step of the reaction without further purification. Yield: 56.14 g (quantitative); Melting point: 102°C. NMR hydrogen spectrum (300 MHz, CDCl3): δ=9.76 (s, 2H, NH2), 3.88 (t, J=5.6 Hz, 2H, CH2), 3.82 (s, 3H, OCH3), 2.83 (t, J=5.2 Hz, 3H, NCH3). NMR carbon spectrum (75MHz, CDCl3): δ=166.7 (C=O), 53.3 (CH2), 48.9 (NCH3), 33.4 (OCH3). Sarcosine methyl ester hydrochloride (59.80 g, 0.43 mol) was suspended in 1.0 L of dichloromethane, and a mixture of triethylamine (119.09 mL, 0.86 mol) and di-tert-butyl dicarbonate (138.01 mL, 0.65 mol) was added slowly and dropwise at 0 °C. After dropwise addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 2 days. After completion of the reaction, the reaction was adjusted to pH=6 by adding 1 M aqueous hydrochloric acid, the organic layer was separated, washed with distilled water, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and volatile impurities were removed overnight under high vacuum to give the clarified oily product methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate. Yield: 78.65 g (90%).
References
[1] Synthesis (Germany), 2017, vol. 49, # 4, p. 770 - 774
[2] Patent: EP1032561, 2004, B1. Location in patent: Page 21
N-Boc-N-methyl glycine methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Boc-N-methyl glycine methyl ester manufacturers
- Product
- Boc-Sar-Ome 42492-57-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-12-27
- Product
- N-Boc-N-methyl glycine methyl ester 42492-57-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- N-Boc-N-methyl glycine methyl ester 42492-57-9
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23