ChemicalBook > CAS DataBase List > DHQHS 2

DHQHS 2

Product Name
DHQHS 2
CAS No.
71939-50-9
Chemical Name
DHQHS 2
Synonyms
Dihydroartemisinin;(3r,5as,6r,8as,9r,10r,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;Dihydroarteminisin;Alaxin;DHQHS 2;Cotexin;Salaxin;Cotecxin;andβArtenimol RS
CBNumber
CB2429120
Molecular Formula
C15H24O5
Formula Weight
284.35
MOL File
71939-50-9.mol
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DHQHS 2 Property

Melting point:
144-149°C
Boiling point:
375.6±42.0 °C(Predicted)
Density 
1.24
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO : 41.67 mg/mL (146.54 mM; Need ultrasonic)
pka
12.61±0.70(Predicted)
form 
solid
color 
White to Almost white
Merck 
14,817
InChI
InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
InChIKey
BJDCWCLMFKKGEE-ISOSDAIHSA-N
SMILES
O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](O)O4)O1
CAS DataBase Reference
71939-50-9(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
KD4165550
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H242Heating may cause a fire

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P410Protect from sunlight.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1200520
Product name
Dihydroartemisinin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$434
Updated
2025/07/31
TCI Chemical
Product number
D3793
Product name
Dihydroartemisinin
Purity
>98.0%(HPLC)
Packaging
1g
Price
$139
Updated
2025/07/31
TCI Chemical
Product number
D3793
Product name
Dihydroartemisinin
Purity
>98.0%(HPLC)
Packaging
5g
Price
$393
Updated
2025/07/31
Cayman Chemical
Product number
19846
Product name
Dihydroartemisinin
Purity
≥98%
Packaging
100mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19846
Product name
Dihydroartemisinin
Purity
≥98%
Packaging
250mg
Price
$56
Updated
2024/03/01
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DHQHS 2 Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

The main metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite

Definition

ChEBI: Artenimol is an artemisinin derivative.

Synthesis

63968-64-9

71939-50-9

The general procedure for the synthesis of (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxahepta[4,3-i]isochromene-10-ol from artemisinin was carried out as follows: under nitrogen protection, a solution of LiBHEt3 (a 1 M solution of tetrahydrofuran) was passed through a syringe was slowly added dropwise to a solution of artemisinin (200 mg, 0.71 mmol) dissolved in anhydrous tetrahydrofuran (20 mL). The temperature of the reaction mixture was maintained constant during the reaction by means of a water or ice water bath. The progress of the reaction was monitored by thin layer chromatography (TLC) until the artemisinin was completely consumed (about 5-10 min). Subsequently, THF solution of acetic acid (20 vol%, 100 μL or 50 μL at a time) was added in batches to quench the reaction and the pH of the reaction mixture was adjusted to 5-6. The reaction mixture was concentrated to dryness under reduced pressure. The dried residue was separated by extraction with ethyl acetate and distilled water. After separation of the organic phase, the aqueous phase was extracted twice more with ethyl acetate. All ethyl acetate extracts were combined and dried with anhydrous sodium sulfate for 6 hours. The dried organic phase was filtered and concentrated to dryness under reduced pressure to give a white flaky target product.

in vivo

,Single oral doses of Dihydroartemisinin (at 200, 300, 400 or 600 mg/kg), given once on each of day 6-8 post-infection, reduce total-worm burdens by 69.2%-90.6% and female-worm burdens by 62.2%-92.2%, depending on dosage in the first experiment. Similar treatments given on day 34-36 post-infection reduce total-worm burdens by 73.9%-85.5% and female-worm burdens by 83.8%-95.3%[3].

IC 50

RelA; Plasmodium; Autophagy

References

[1] Molecules, 2011, vol. 16, # 6, p. 4527 - 4538
[2] Journal of the Chemical Society. Perkin Transactions 1, 2001, # 19, p. 2421 - 2429
[3] Patent: WO2013/38206, 2013, A1. Location in patent: Paragraph 10; 11
[4] Journal of the American Chemical Society, 2011, vol. 133, # 7, p. 2076 - 2079
[5] Organic Process Research and Development, 2007, vol. 11, # 3, p. 336 - 340

DHQHS 2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DHQHS 2 manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
Dihydroartemisinin 71939-50-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-21
Shaanxi Xianhe Biotech Co., Ltd
Product
DHQHS 2 71939-50-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2025-04-25
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Dihydroartemisinin 71939-50-9
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-10

71939-50-9, DHQHS 2Related Search:

Stanolone Hydrochlorothiazide Artemisinin Podophyllotoxin Metronidazole Dihydro Artemisinin-d3 Dihydroartemisinin 2-ETHYLHEXANAL DIMETHYL ACETAL tert-Butyl hydroperoxide tert-Amyl hydroperoxide dihydroartemisinin ethyl ether Di-tert-butyl peroxide alpha-dihydroartemisinin Dihydro ArteMisinin-13C,d4 Diketo aldehyde iMpurity of dihydroarteMisinin (3aS,4R,6aS,7R,10R,10aR)-Octahydro-4,7-diMethyl-2H,10H-furo[3,2-i][2]benzopyran-8,10-diol 10-Acetate (11S)-Dihydroartemisinic Acid 1,1-DI(2-METHYLBUTOXY)ETHANE

  • Dihydroartemisinin 71939-50-9
  • Dihydroartemisinin (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
  • ]hexadecan-6-ol
  • Dihydroarteminisin
  • Dihydroartemisin
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
  • Alaxin
  • b-Dihydroartemisinin
  • Cotecxin
  • Cotexin
  • DHQHS 2
  • Dihydroqinghaosu
  • dihydroquinghaosu
  • Dihydroartemisinin
  • 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol,decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
  • Salaxin
  • Santecxin Dihydroqinghaosu
  • (3r,5as,6r,8as,9r,10r,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
  • (3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
  • (3R,5aα,8aα,12aR)-Decahydro-3,6α,9β-trimethyl-3β,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin-10β-ol
  • Dihydroginghaosu
  • DihydroarteMisinin alpha and beta Mixtures
  • Artemether Related Compound A (15 mg) ((3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-10-hydroxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin)
  • ArteMether Related CoMpound A
  • and&beta
  • DihydroarteMisinin,Mixtureof&alpha
  • Dihydroartemisinin (DHA)
  • Dihydroartemisinin,mixture of α and β isomers
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
  • DihydroarteMisinin, 98.0%
  • Dihydroartemisinin, >=99%
  • (3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-10-hydroxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
  • Dihydroartemisinin&gt
  • (3S,5aS,8R,8aS,11R,12S,12aR)-3,8,11-trimethyloctahydro-5aH,7H-3,12-methano[1,2,5]trioxepino[3,4-j]isochromen-7-ol
  • DHQHS 2 USP/EP/BP
  • Artemether Related Compound A (Artemisinin Dihydro Impurity)
  • Artemisinin Dihydro Impurity (Artemether Related Compound A)
  • β-Dihydroartemisinin
  • Dihydroartemisinin 13CD3Q: What is Dihydroartemisinin 13CD3 Q: What is the CAS Number of Dihydroartemisinin 13CD3
  • DihydroartemisininQ: What is Dihydroartemisinin Q: What is the CAS Number of Dihydroartemisinin Q: What is the storage condition of Dihydroartemisinin Q: What are the applications of Dihydroartemisinin
  • C[C@@H]1CC[C@H]3[C@@H](C)[C@@H](O)O[C@@H]2O[C@@]4(C)CC[C@@H]1[C@]23OO4
  • DHQHS 2, Dihydroartemisinin
  • Artemether?USP?RC?A
  • (3R, 5aS, 6R, 8aS, 9R, 10S, 12R, 12aR) -3,6,9-trimethyldecahydro-3H-3,12-epoxy [1,2] dioxane [4,3-i] isobenzopyran-10 alcohol
  • Artesate 13CD4
  • 13C,2H4]-Dihydroartemisinin, isomers mixture
  • Dihydroartemisinin, active metabolite of artemether and artesunate
  • Dihydroartemisinin, 10 mM in DMSO
  • DHA (Dihydroartemisinin)
  • Artenimol RS
  • 71939-50-9
  • 71933-50-9
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