DHQHS 2

Product Name: DHQHS 2
CAS No.: 71939-50-9
Chemical Name: DHQHS 2
Synonyms: Dihydroartemisinin;(3r,5as,6r,8as,9r,10r,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;Dihydroarteminisin;Alaxin;DHQHS 2;Cotexin;Salaxin;Cotecxin;andβArtenimol RS
CBNumber: CB2429120
Molecular Formula: C15H24O5
Formula Weight: 284.35
MOL File: 71939-50-9.mol

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DHQHS 2 Property

Melting point:: 144-149°C
Boiling point:: 375.6±42.0 °C(Predicted)
Density: 1.24
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO : 41.67 mg/mL (146.54 mM; Need ultrasonic)
pka: 12.61±0.70(Predicted)
form: solid
color: White to Almost white
Merck: 14,817
InChI: InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
InChIKey: BJDCWCLMFKKGEE-ISOSDAIHSA-N
SMILES: O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](O)O4)O1
CAS DataBase Reference: 71939-50-9(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 2
RTECS: KD4165550
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H242Heating may cause a fire

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P410Protect from sunlight.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1200520
Product name: Dihydroartemisinin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $434
Updated: 2025/07/31

TCI Chemical

Product number: D3793
Product name: Dihydroartemisinin
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $139
Updated: 2025/07/31

TCI Chemical

Product number: D3793
Product name: Dihydroartemisinin
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $393
Updated: 2025/07/31

Cayman Chemical

Product number: 19846
Product name: Dihydroartemisinin
Purity: ≥98%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19846
Product name: Dihydroartemisinin
Purity: ≥98%
Packaging: 250mg
Price: $56
Updated: 2024/03/01

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DHQHS 2 Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

The main metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite

Definition

ChEBI: Artenimol is an artemisinin derivative.

Synthesis

63968-64-9

71939-50-9

The general procedure for the synthesis of (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxahepta[4,3-i]isochromene-10-ol from artemisinin was carried out as follows: under nitrogen protection, a solution of LiBHEt3 (a 1 M solution of tetrahydrofuran) was passed through a syringe was slowly added dropwise to a solution of artemisinin (200 mg, 0.71 mmol) dissolved in anhydrous tetrahydrofuran (20 mL). The temperature of the reaction mixture was maintained constant during the reaction by means of a water or ice water bath. The progress of the reaction was monitored by thin layer chromatography (TLC) until the artemisinin was completely consumed (about 5-10 min). Subsequently, THF solution of acetic acid (20 vol%, 100 μL or 50 μL at a time) was added in batches to quench the reaction and the pH of the reaction mixture was adjusted to 5-6. The reaction mixture was concentrated to dryness under reduced pressure. The dried residue was separated by extraction with ethyl acetate and distilled water. After separation of the organic phase, the aqueous phase was extracted twice more with ethyl acetate. All ethyl acetate extracts were combined and dried with anhydrous sodium sulfate for 6 hours. The dried organic phase was filtered and concentrated to dryness under reduced pressure to give a white flaky target product.

in vivo

,Single oral doses of Dihydroartemisinin (at 200, 300, 400 or 600 mg/kg), given once on each of day 6-8 post-infection, reduce total-worm burdens by 69.2%-90.6% and female-worm burdens by 62.2%-92.2%, depending on dosage in the first experiment. Similar treatments given on day 34-36 post-infection reduce total-worm burdens by 73.9%-85.5% and female-worm burdens by 83.8%-95.3%^[3].

IC 50

RelA; Plasmodium; Autophagy

References

[1] Molecules, 2011, vol. 16, # 6, p. 4527 - 4538
[2] Journal of the Chemical Society. Perkin Transactions 1, 2001, # 19, p. 2421 - 2429
[3] Patent: WO2013/38206, 2013, A1. Location in patent: Paragraph 10; 11
[4] Journal of the American Chemical Society, 2011, vol. 133, # 7, p. 2076 - 2079
[5] Organic Process Research and Development, 2007, vol. 11, # 3, p. 336 - 340

DHQHS 2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DHQHS 2 manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: Dihydroartemisinin 71939-50-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-21

Shaanxi Xianhe Biotech Co., Ltd

Product: DHQHS 2 71939-50-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-25

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Dihydroartemisinin 71939-50-9
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-10

71939-50-9, DHQHS 2Related Search:

Stanolone Hydrochlorothiazide Artemisinin Podophyllotoxin Metronidazole Dihydro Artemisinin-d3 Dihydroartemisinin 2-ETHYLHEXANAL DIMETHYL ACETAL tert-Butyl hydroperoxide tert-Amyl hydroperoxide dihydroartemisinin ethyl ether Di-tert-butyl peroxide alpha-dihydroartemisinin Dihydro ArteMisinin-13C,d4 Diketo aldehyde iMpurity of dihydroarteMisinin (3aS,4R,6aS,7R,10R,10aR)-Octahydro-4,7-diMethyl-2H,10H-furo[3,2-i][2]benzopyran-8,10-diol 10-Acetate (11S)-Dihydroartemisinic Acid 1,1-DI(2-METHYLBUTOXY)ETHANE

Dihydroartemisinin 71939-50-9

Dihydroartemisinin (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol

]hexadecan-6-ol

Dihydroarteminisin

Dihydroartemisin

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol

Alaxin

b-Dihydroartemisinin

Cotecxin

Cotexin

DHQHS 2

Dihydroqinghaosu

dihydroquinghaosu

Dihydroartemisinin

3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol,decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-

Salaxin

Santecxin Dihydroqinghaosu

(3r,5as,6r,8as,9r,10r,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol

(3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol

(3R,5aα,8aα,12aR)-Decahydro-3,6α,9β-trimethyl-3β,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin-10β-ol

Dihydroginghaosu

DihydroarteMisinin alpha and beta Mixtures

Artemether Related Compound A (15 mg) ((3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-10-hydroxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin)

ArteMether Related CoMpound A

and&beta

DihydroarteMisinin,Mixtureof&alpha

Dihydroartemisinin (DHA)

Dihydroartemisinin,mixture of α and β isomers

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol

DihydroarteMisinin, 98.0%

Dihydroartemisinin, >=99%

(3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-10-hydroxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

Dihydroartemisinin&gt

(3S,5aS,8R,8aS,11R,12S,12aR)-3,8,11-trimethyloctahydro-5aH,7H-3,12-methano[1,2,5]trioxepino[3,4-j]isochromen-7-ol

DHQHS 2 USP/EP/BP

Artemether Related Compound A (Artemisinin Dihydro Impurity)

Artemisinin Dihydro Impurity (Artemether Related Compound A)

β-Dihydroartemisinin

Dihydroartemisinin 13CD3Q: What is Dihydroartemisinin 13CD3 Q: What is the CAS Number of Dihydroartemisinin 13CD3

DihydroartemisininQ: What is Dihydroartemisinin Q: What is the CAS Number of Dihydroartemisinin Q: What is the storage condition of Dihydroartemisinin Q: What are the applications of Dihydroartemisinin

C[C@@H]1CC[C@H]3[C@@H](C)[C@@H](O)O[C@@H]2O[C@@]4(C)CC[C@@H]1[C@]23OO4

DHQHS 2, Dihydroartemisinin

Artemether?USP?RC?A

(3R, 5aS, 6R, 8aS, 9R, 10S, 12R, 12aR) -3,6,9-trimethyldecahydro-3H-3,12-epoxy [1,2] dioxane [4,3-i] isobenzopyran-10 alcohol

Artesate 13CD4

13C,2H4]-Dihydroartemisinin, isomers mixture

Dihydroartemisinin, active metabolite of artemether and artesunate

Dihydroartemisinin, 10 mM in DMSO

DHA (Dihydroartemisinin)

Artenimol RS

71939-50-9

71933-50-9

Analytical Standards

Analytical Chromatography Product Catalog

DID - DIN

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Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals