DHQHS 2
- Product Name
- DHQHS 2
- CAS No.
- 71939-50-9
- Chemical Name
- DHQHS 2
- Synonyms
- Dihydroartemisinin;(3r,5as,6r,8as,9r,10r,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;Dihydroarteminisin;Alaxin;DHQHS 2;Cotexin;Salaxin;Cotecxin;andβArtenimol RS
- CBNumber
- CB2429120
- Molecular Formula
- C15H24O5
- Formula Weight
- 284.35
- MOL File
- 71939-50-9.mol
DHQHS 2 Property
- Melting point:
- 144-149°C
- Boiling point:
- 375.6±42.0 °C(Predicted)
- Density
- 1.24
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO : 41.67 mg/mL (146.54 mM; Need ultrasonic)
- pka
- 12.61±0.70(Predicted)
- form
- solid
- color
- White to Almost white
- Merck
- 14,817
- InChI
- InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
- InChIKey
- BJDCWCLMFKKGEE-ISOSDAIHSA-N
- SMILES
- O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](O)O4)O1
- CAS DataBase Reference
- 71939-50-9(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 2
- RTECS
- KD4165550
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H242Heating may cause a fire
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P235Keep cool.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P410Protect from sunlight.
N-Bromosuccinimide Price
- Product number
- 1200520
- Product name
- Dihydroartemisinin
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $434
- Updated
- 2025/07/31
- Product number
- D3793
- Product name
- Dihydroartemisinin
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $139
- Updated
- 2025/07/31
- Product number
- D3793
- Product name
- Dihydroartemisinin
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $393
- Updated
- 2025/07/31
- Product number
- 19846
- Product name
- Dihydroartemisinin
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19846
- Product name
- Dihydroartemisinin
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $56
- Updated
- 2024/03/01
DHQHS 2 Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
The main metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite
Definition
ChEBI: Artenimol is an artemisinin derivative.
Synthesis
63968-64-9
71939-50-9
The general procedure for the synthesis of (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxahepta[4,3-i]isochromene-10-ol from artemisinin was carried out as follows: under nitrogen protection, a solution of LiBHEt3 (a 1 M solution of tetrahydrofuran) was passed through a syringe was slowly added dropwise to a solution of artemisinin (200 mg, 0.71 mmol) dissolved in anhydrous tetrahydrofuran (20 mL). The temperature of the reaction mixture was maintained constant during the reaction by means of a water or ice water bath. The progress of the reaction was monitored by thin layer chromatography (TLC) until the artemisinin was completely consumed (about 5-10 min). Subsequently, THF solution of acetic acid (20 vol%, 100 μL or 50 μL at a time) was added in batches to quench the reaction and the pH of the reaction mixture was adjusted to 5-6. The reaction mixture was concentrated to dryness under reduced pressure. The dried residue was separated by extraction with ethyl acetate and distilled water. After separation of the organic phase, the aqueous phase was extracted twice more with ethyl acetate. All ethyl acetate extracts were combined and dried with anhydrous sodium sulfate for 6 hours. The dried organic phase was filtered and concentrated to dryness under reduced pressure to give a white flaky target product.
in vivo
,Single oral doses of Dihydroartemisinin (at 200, 300, 400 or 600 mg/kg), given once on each of day 6-8 post-infection, reduce total-worm burdens by 69.2%-90.6% and female-worm burdens by 62.2%-92.2%, depending on dosage in the first experiment. Similar treatments given on day 34-36 post-infection reduce total-worm burdens by 73.9%-85.5% and female-worm burdens by 83.8%-95.3%[3].
IC 50
RelA; Plasmodium; Autophagy
References
[1] Molecules, 2011, vol. 16, # 6, p. 4527 - 4538
[2] Journal of the Chemical Society. Perkin Transactions 1, 2001, # 19, p. 2421 - 2429
[3] Patent: WO2013/38206, 2013, A1. Location in patent: Paragraph 10; 11
[4] Journal of the American Chemical Society, 2011, vol. 133, # 7, p. 2076 - 2079
[5] Organic Process Research and Development, 2007, vol. 11, # 3, p. 336 - 340
DHQHS 2 Preparation Products And Raw materials
Raw materials
Preparation Products
DHQHS 2 Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from DHQHS 2 manufacturers
- Product
- Dihydroartemisinin 71939-50-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-21
- Product
- DHQHS 2 71939-50-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-25
- Product
- Dihydroartemisinin 71939-50-9
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-10