METHYL 2,6-DIFLUOROBENZOATE
- Product Name
- METHYL 2,6-DIFLUOROBENZOATE
- CAS No.
- 13671-00-6
- Chemical Name
- METHYL 2,6-DIFLUOROBENZOATE
- Synonyms
- RARECHEM AL BF 0212;2,6-difluorobenzoate;METHYL 2,6-DIFLUOROBENZOATE;2,5-difluoro-3-methylbenzoate;Methyl2,6-difluorobenzoate98%;Methyl 2,6-difluorobenzoate 98%;Methyl 2,6-difluorobenzoate, 97%+;2,6-DIFLUOROBENZOIC ACID METHYL ESTER;2-(Methoxycarbonyl)-1,3-difluorobenzene;Benzoic acid, 2,6-difluoro-, Methyl ester
- CBNumber
- CB2438267
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 13671-00-6.mol
METHYL 2,6-DIFLUOROBENZOATE Property
- Boiling point:
- 203-204 °C (lit.)
- Density
- 1.281 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.476(lit.)
- Flash point:
- 203 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- fused solid
- color
- White to off white
- BRN
- 1948618
- CAS DataBase Reference
- 13671-00-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38
- Safety Statements
- 26-36-26/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 542636
- Product name
- Methyl 2,6-difluorobenzoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $72.29
- Updated
- 2025/07/31
- Product number
- M301815
- Product name
- Methyl 2,6-difluorobenzoate
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC5075E
- Product name
- Methyl 2,6-difluorobenzoate
- Purity
- 98%
- Packaging
- 100g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 002748
- Product name
- Methyl 2,6-difluorobenzoate
- Purity
- 98%
- Packaging
- 100g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- CS-M0553
- Product name
- Methyl 2,6-difluorobenzoate
- Purity
- 99.87%
- Packaging
- 100g
- Price
- $74
- Updated
- 2021/12/16
METHYL 2,6-DIFLUOROBENZOATE Chemical Properties,Usage,Production
Uses
Methyl 2,6-difluorobenzoate may be used in the synthesis of 9-hydroxy-13-(2,6-difluorophenyl)-3H-dibenzo[b,i]xanthen-3-one and 2,6-difluorobenzohydroxamic acid.
General Description
Methyl 2,6-difluorobenzoate is a fluorinated aromatic ester. It can be synthesized from 2,6-difluorobenzoic acid via esterification with methanol.
Synthesis
67-56-1
385-00-2
13671-00-6
GENERAL METHOD: A catalytic amount of concentrated H2SO4 (0.1 mmol) was added to a methanol (50 mL) solution of 2,6-difluorobenzoic acid (1.0 mmol) and the mixture was heated to reflux for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, saturated NaHCO3 solution (50 mL) was added to the reaction mixture to neutralize the acidic conditions, and then the product was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give pure methyl 2,6-difluorobenzoate.
References
[1] Organic Process Research and Development, 2016, vol. 20, # 2, p. 233 - 241
[2] Medicinal Chemistry Research, 2016, vol. 25, # 4, p. 627 - 643
[3] Patent: WO2011/59610, 2011, A1. Location in patent: Page/Page column 101-102
[4] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 25
[5] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0147-0149
METHYL 2,6-DIFLUOROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2,6-DIFLUOROBENZOATE manufacturers
- Product
- Methyl 2,6-difluorobenzoate 13671-00-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- METHYL 2,6-DIFLUOROBENZOATE 13671-00-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2019-01-02