1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

Product Name: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
CAS No.: 27387-31-1
Chemical Name: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Synonyms: N-Methylcarbazolone;ONDANSETRON EP IMP C;Ondansetron Impurity C;Ondansetron EP Impurity C;1,2,3,9-Tetrahydro-9-Methyl-4H;Ondansetron Related CoMpound C;Ondansetron impurity C (PhEur);1,2,3,4-tetrahydro-4-oxocarbazolt;1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE;Ondansetron USP Related Compound C
CBNumber: CB2441827
Molecular Formula: C13H13NO
Formula Weight: 199.25
MOL File: 27387-31-1.mol

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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Property

Melting point:: 199.0 to 203.0 °C
Boiling point:: 383.5±11.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form: solid
color: White to Light yellow
BRN: 153862
InChI: InChI=1S/C13H13NO/c1-14-10-6-3-2-5-9(10)13-11(14)7-4-8-12(13)15/h2-3,5-6H,4,7-8H2,1H3
InChIKey: HHJUJCWZKJMCLC-UHFFFAOYSA-N
SMILES: N1(C)C2=C(C=CC=C2)C2=C1CCCC2=O
CAS DataBase Reference: 27387-31-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-52/53-25
Safety Statements: 22-24/25-61-45
RIDADR: UN 2811 6.1 / PGIII
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2224
Product name: Ondansetron Related Compound C
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 100mg
Price: $389.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1478618
Product name: Ondansetron Related Compound C
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 30mg
Price: $1360
Updated: 2025/07/31

TCI Chemical

Product number: T2942
Product name: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Purity: >98.0%(GC)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: T2942
Product name: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Purity: >98.0%(GC)
Packaging: 25g
Price: $142
Updated: 2025/07/31

TRC

Product number: T293920
Product name: 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one
Packaging: 1g
Price: $305
Updated: 2021/12/16

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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Chemical Properties,Usage,Production

Chemical Properties

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is Off-White Solid

Uses

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is an impurity of Ondansetron (O655000).

Synthesis

15128-52-6

4637-24-5

27387-31-1

The reaction was carried out in N,N-dimethylformamide (5.0 mL) at reflux for 1.0 h with 2,3-dihydro-1H-carbazol-4(9H)-one (1.0 mmol) and N,N-dimethylformamide dimethyl acetal (10 mmol). After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (2 x 25 mL). The organic layer was separated and washed with saturated brine solution and subsequently dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the resulting solid was recrystallized from ethanol to give white acicular crystals in 71% yield, melting point 188-190 °C. IR (cm-1 ): 1695 (C=O). 1H NMR (400 MHz, CDCl3) δ: 2.24-2.27 (t, 2H, CH2, J = 6.28 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz). CH2, J = 6.0 Hz), 2.91-2.94 (t, 2H, CH2, J = 6.21 Hz), 3.70 (s, 3H, NCH3), 7.27-7.30 (m, 3H, Ph), 8.24-8.26 (m, 1H, Ph). Calculated elemental analysis (C13H13NO): C, 78.36; H, 6.58; N, 7.03%. Measured values: C, 78.29; H, 6.49; N, 6.92%.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53B, # 12, p. 1606 - 1610
[2] Journal of Molecular Structure, 2014, vol. 1080, p. 137 - 144
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1887 - 1891

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Preparation Products And Raw materials

Raw materials

Acrylic acid Phenylhydrazine

Preparation Products

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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Suppliers

Canada 1 China 219 Europe 2 Germany 3 India 42 Japan 2 Russia 1 Slovakia 1 Ukraine 1 United Kingdom 8 United States 31 Global 311

Shandong Jiecheng Pharmaceutical Co., Ltd

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View Lastest Price from 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1
Price: US $0.00-0.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: 200tons
Release date: 2025-04-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-17

Henan Aochuang Chemical Co.,Ltd.

Product: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2025-04-01

27387-31-1, 1,2,3,4-Tetrahydro-9-methylcarbazol-4-oneRelated Search:

Methylparaben Tetramethylammonium hydroxide pentahydrate Paraquat dichloride Mesotrione Acetonitrile Methyl acrylate Basic Violet 1 Carbazole 4-Methyl-2-pentanone 1,1,3,3-Tetramethyldisiloxane Methyl tetrahydrophthalic anhydride 6-Methyl-5-hepten-2-one Kresoxim-methyl Methanol N-Methyl-2-pyrrolidone Methyl Ondansetron EP Impurity G 3-[(Dimethylamino)methyl]-9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE

9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE

9-METHYL-1,2,3,9-TETRAHYDRO-CARBAZOL-4-ONE

9-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOL-4-ONE

9-METHYL-1,2,3,4-TETRAHYDRO-4-OXOCARBAZOLE

9-METHYL-1,2.3,4-TETRAHYDRO-4-OXOCARBAZOLE-4-ONE

Ondansetron EP Impurity C (USP RC C)

1,2,3,4a,9,9a‐Hexahydro‐9‐ methyl‐4H‐carbazol‐4‐one

9-Methyl-1,2,3,4-tetrahydrocarbazol-4-one

Ondansetron Impurity C

Ondansetron Hydrochloride Dihydrate EP Impurity C (USP RC C)

1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE

1,2,3,9-TETRAHYDRO-9-METHYL CARBAZOLE-4-ONE

1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE

1,2,3,4-TETRAHYDRO-9METHYL-4H-CARBAZOLE-4-ONE

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One99%

N-Methylcarbazolone

1,2,3,4-tetrahydro-4-oxocarbazolt

1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONEONDANSETRON

1,2,3,9-Tetrahydro-9-Methyl-4H

1,2,3,4-TETRAHYDRO-9-METHCARBAZOL-4-ONE

1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one

N-METHYL-4-OXO-1,2,3,4-TETRAHYDROCARBAZOLE

9-Methyl-2,3-dihydro-1H-carbazol-4-one

Ondansetron HCl EP IMpurity-C (USP RC C)

Ondansetron Related CoMpound C

Ondansetron impurity C (PhEur)

Ondansetron Related Compound C (USP)

9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one

Ondansetron EP Impurity C

Ondansetron Impurity 3（Ondansetron EP Impurity C）

Ondansetron EP Impurity C (Ondansetron USP Related Compound C)

4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-

1,2,3,4-Tetrahydro-9-methyl-4-oxocarbazole

1,2,3,9-Tetrahydro-9-methylcarbazol-4-one

4-Tetrahydro-9-methylcarbazol-4-one

Ondansetron EP Impurity C/ Ondansetron Related Compound C

1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C)Q: What is 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the CAS Number of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the storage condition of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What are the applications of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C)

Ondansetron Related Compound C (1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one) (1478618)

Ondansetron USP Related Compound C

Ondansetron Hydrochloride Dihydrate EP Impurity C

1,2,3,9-TETRA HYDRO-9-METHYL-4(H)-CARBAZOL-4-ONE/MCZ

Ondansetron Related Compound C (30 mg) (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one)

ONDANSETRON EP IMP C

2,3, - dihydro -9-methyl -1H-carbazol – 4(9H) - one

Ondansetron EP Impurity C 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

27387-31-1

27397-31-1

C13H15NO

Aromatics

Heterocycles

Impurities

Intermediates