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2-(Trifluoromethyl)benzyl alcohol

Product Name
2-(Trifluoromethyl)benzyl alcohol
CAS No.
346-06-5
Chemical Name
2-(Trifluoromethyl)benzyl alcohol
Synonyms
OTF-BYL;RARECHEM AL BD 0046;2-TRIFLUOROBENZYL ALCOHOL;o-Trifluoromethylbenzyl alchol;2-Hydroxymethylbenzotrifluoride;2-(TRIFLUOROMETHYL)BENZYL ALCOHOL;O-(TRIFLUOROMETHYL)BENZYL ALCOHOL;2-TRIFLUOROMETHYL BENZENE METHANOL;[2-(TRIFLUOROMETHYL)PHENYL]METHANOL;2-(Trifluoromethyl)benzylalcohol97%
CBNumber
CB2443003
Molecular Formula
C8H7F3O
Formula Weight
176.14
MOL File
346-06-5.mol
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2-(Trifluoromethyl)benzyl alcohol Property

Melting point:
4°C
Boiling point:
90 °C20 mm Hg(lit.)
Density 
1.326 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.468(lit.)
Flash point:
198 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
pka
14.01±0.10(Predicted)
color 
Colorless to Almost colorless
BRN 
2093714
CAS DataBase Reference
346-06-5(CAS DataBase Reference)
NIST Chemistry Reference
2-(Trifluoromethyl)benzyl alcohol(346-06-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29062990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233102
Product name
2-(Trifluoromethyl)benzyl alcohol
Purity
97%
Packaging
5g
Price
$33.6
Updated
2022/05/15
TCI Chemical
Product number
T1311
Product name
2-(Trifluoromethyl)benzyl Alcohol
Purity
>98.0%(GC)
Packaging
5g
Price
$40
Updated
2025/07/31
TRC
Product number
T797015
Product name
2-(Trifluoromethyl)benzyl Alcohol
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
T797015
Product name
2-(Trifluoromethyl)benzyl Alcohol
Packaging
500mg
Price
$75
Updated
2021/12/16
Oakwood
Product number
001975
Product name
2-(Trifluoromethyl)benzyl Alcohol
Purity
97%
Packaging
1g
Price
$9
Updated
2021/12/16
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2-(Trifluoromethyl)benzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

2-(Trifluoromethyl)benzyl alcohol has been used to investigate the aromatic aldehydes as substrate for yeast alcohol dehydrogenase.

Definition

ChEBI: [2-(Trifluoromethyl)phenyl]methanol is a member of (trifluoromethyl)benzenes.

Synthesis

447-61-0

346-06-5

(1) Water (348.0 g) was added to a 1000 mL three-necked round-bottomed flask equipped with a mechanical stirrer and a thermometer and cooled to 0°C. Subsequently, sodium borohydride (9.5 g, 0.25 mol) was added and stirred for 20 min. Maintaining the temperature at 5 °C, o-trifluoromethylbenzaldehyde (87.1 g, 0.5 mol) was slowly added dropwise. After the dropwise addition, the reaction temperature was maintained at 10 °C for 1 hour. After completion of the reaction, extraction was carried out by adding methyl tert-butyl ether. The organic phases were combined, washed with saturated brine and concentrated under reduced pressure to no fraction to obtain 2-trifluoromethylbenzenemethanol as a colorless transparent liquid with a purity of >99% and a yield of 90%.

References

[1] Patent: CN106588673, 2017, A. Location in patent: Paragraph 0047; 0048
[2] Patent: CN106699729, 2017, A. Location in patent: Paragraph 0066; 0067
[3] Green Chemistry, 2015, vol. 17, # 9, p. 4537 - 4540
[4] Journal of Organic Chemistry, 2017, vol. 82, # 13, p. 6972 - 6977

2-(Trifluoromethyl)benzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Trifluoromethyl)benzyl alcohol Suppliers

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View Lastest Price from 2-(Trifluoromethyl)benzyl alcohol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-(Trifluoromethyl)benzyl alcohol 346-06-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-06-11
Longyan Tianhua Biological Technology Co., Ltd
Product
2-(Trifluoromethyl)benzyl alcohol 346-06-5
Price
US $130.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10000KG
Release date
2020-11-09
Career Henan Chemical Co
Product
2-(Trifluoromethyl)benzyl alcohol 346-06-5
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
as request
Release date
2018-12-21

346-06-5, 2-(Trifluoromethyl)benzyl alcoholRelated Search:

3-FLUORO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL 5-FLUORO-2-(TRIFLUOROMETHYL)BENZYL ALCOHOL 2-CHLORO-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL 2,3,5,6-TETRAFLUORO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL 4-amino-à-à-bis(trifluoromethyl)benzyl alcohol 1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL, 9 8%,ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL 2-Fluoro-4-(trifluoromethyl)benzyl alcohol 97% ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL,à-(trifluoromethyl)benzyl alcohol O-(TRIFLUOROMETHYL)BENZYL ALCOHOL ALPHA-METHYL-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL,ALPHA-METHYL-M-(TRIFLUOROMETHYL)BENZYL ALCOHOL P-(TRIFLUOROMETHYL)BENZYL ALCOHOL,4-(TRIFLUOROMETHYL)BENZYL ALCOHOL 4-FLUORO-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL α,α-bis(trifluoromethyl)benzyl alcohol,à,à-bis(trifluoromethyl)benzyl alcohol,ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)BENZYL ALCOHOL alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol (S)-5-chloro-a-(Cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-a- (trifluoromethyl) benzenemethanol (E-4) 2-Fluoro-5-(trifluoromethyl)benzyl alcohol 97% M-(TRIFLUOROMETHYL)BENZYL ALCOHOL

  • 2-(Trifluoromethyl)benzyl alcohol 97%
  • 2-TRIFLUOROBENZYL ALCOHOL
  • 2-(Trifluoromethyl)benzylalcohol97%
  • RARECHEM AL BD 0046
  • OTF-BYL
  • O-(TRIFLUOROMETHYL)BENZYL ALCOHOL
  • 2-(TRIFLUOROMETHYL)BENZYL ALCOHOL
  • 2-TRIFLUOROMETHYL BENZENE METHANOL
  • [2-(TRIFLUOROMETHYL)PHENYL]METHANOL
  • Benzenemethanol, 2-(trifluoromethyl)-
  • 2-(trifluoromethyl)benzylic alcohol
  • o-Trifluoromethylbenzyl alchol
  • 2-Hydroxymethylbenzotrifluoride
  • 2-(TrifluoroMethyl)benzyl alcohol, 97% 5GR
  • 346-06-5
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