1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL

Product Name: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
CAS No.: 368-63-8
Chemical Name: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
Synonyms: 3,5-Bis(trifluoromethyl)phenylethanol;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;(1R)-1-[3,7-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL;ALPHA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol;alpha-methyl-3,5-bis(trifluoromethyl)benzyl alchol;alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol
CBNumber: CB8113483
Molecular Formula: C10H8F6O
Formula Weight: 258.16
MOL File: 368-63-8.mol

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1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Property

Melting point:: 70-74℃
Boiling point:: 175.8±35.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.99±0.20(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 368-63-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2906290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: T790983
Product name: 1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC7869
Product name: alpha-Methyl-3,5-bis(trifluoromethyl)benzylalcohol
Purity: 99+%
Packaging: 1g
Price: $29
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2802-3-08
Product name: 1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: 99.0%
Packaging: 1g
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2802-3-08
Product name: 1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: 99.0%
Packaging: 5G
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: Z4663
Product name: 1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
Packaging: 5g
Price: $223
Updated: 2021/12/16

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1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Chemical Properties,Usage,Production

Synthesis

30071-93-3

7480-35-5

368-63-8

The general procedure for the synthesis of (R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol from 3,5-bis(trifluoromethyl)acetophenone and cis-1-amino-2,3-dihydro-1H-inden-2-ol is as follows: Example 5: To 2-propanol (21 L), [RuCl2 (p-cymene)]2 (18.4 g), (1S,2R)-cis-1-amino-2,3-dihydro-1H-inden-2-ol (9.0 g), and 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (3 kg) were added, stirred for 30 minutes and thoroughly degassed under vacuum. Subsequently, 5M sodium hydroxide solution (28mL) was added and the mixture was aged for 4-6 hours to ensure complete conversion of the feedstock. Upon completion of the reaction, the reaction mixture was poured into 1N HCl (21 L) and extracted with heptane (2 x 10.5 L). The organic layers were combined, washed with brine, and 1,4-diazabicyclo[2.2.2]octane (740 g) was added. The solution was concentrated to nearly 4 mL/g of alcohol (KF < 200 μg/mL; 2-propanol < 5 vol%). After inoculation at 40°C, the mixture was allowed to cool to room temperature to form crystalline species, which were further cooled to 0°C. The crystalline product was obtained by filtration, washed with cold heptane and dried to give the final DABCO complex in 75-80% yield and ee value >99%.

References

[1] Patent: US2002/22725, 2002, A1
[2] Patent: US2002/52493, 2002, A1
[3] Patent: US2002/52494, 2002, A1
[4] Patent: US6432952, 2002, B1
[5] Patent: US2003/215456, 2003, A1

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Suppliers

Canada 1 China 74 Europe 1 Germany 1 India 4 Switzerland 1 United Kingdom 9 United States 14 Global 105

Alfa Aesar

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Shanghai Yolne Chemical Co., Ltd.

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Cochemical Ltd.

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View Lastest Price from 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL manufacturers

Honest Joy Holdings Limited

Product: 1-(3,5-bis(trifluoromethyl)phenyl)ethanol 368-63-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 100 tons
Release date: 2022-02-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL 368-63-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL 368-63-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

368-63-8, 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OLRelated Search:

3,5-Bis(trifluoromethyl)benzyl alcohol 1-[2,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol (R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL

ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL

alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol

3,5-Bis(trifluoromethyl)phenylethanol

alpha-Methyl-3,5-Bis(trifluoromethyl)Benzylalcohol99+%

à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol

(1R)-1-[3,7-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

ALPHA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL

3-AMINO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE (3-AMINO LACTAM)

BenzeneMethanol, a-Methyl-3,5-bis(trifluoroMethyl)-

alpha-methyl-3,5-bis(trifluoromethyl)benzyl alchol

Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-

1-(3,5-Bis(trifluoromethyl)phenyl)ethanol - [B92884]

368-63-8

C10H8F8O

PHARMACEUTICAL INTERMEDIATES

Aromatic alcohols and diols