1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
- Product Name
- 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
- CAS No.
- 368-63-8
- Chemical Name
- 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
- Synonyms
- 3,5-Bis(trifluoromethyl)phenylethanol;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;(1R)-1-[3,7-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL;ALPHA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol;alpha-methyl-3,5-bis(trifluoromethyl)benzyl alchol;alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol
- CBNumber
- CB8113483
- Molecular Formula
- C10H8F6O
- Formula Weight
- 258.16
- MOL File
- 368-63-8.mol
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Property
- Melting point:
- 70-74℃
- Boiling point:
- 175.8±35.0 °C(Predicted)
- Density
- 1.376±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.99±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 368-63-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T790983
- Product name
- 1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC7869
- Product name
- alpha-Methyl-3,5-bis(trifluoromethyl)benzylalcohol
- Purity
- 99+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 2802-3-08
- Product name
- 1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
- Purity
- 99.0%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 2802-3-08
- Product name
- 1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
- Purity
- 99.0%
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- Z4663
- Product name
- 1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
- Packaging
- 5g
- Price
- $223
- Updated
- 2021/12/16
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Chemical Properties,Usage,Production
Synthesis
30071-93-3
7480-35-5
368-63-8
The general procedure for the synthesis of (R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol from 3,5-bis(trifluoromethyl)acetophenone and cis-1-amino-2,3-dihydro-1H-inden-2-ol is as follows: Example 5: To 2-propanol (21 L), [RuCl2 (p-cymene)]2 (18.4 g), (1S,2R)-cis-1-amino-2,3-dihydro-1H-inden-2-ol (9.0 g), and 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (3 kg) were added, stirred for 30 minutes and thoroughly degassed under vacuum. Subsequently, 5M sodium hydroxide solution (28mL) was added and the mixture was aged for 4-6 hours to ensure complete conversion of the feedstock. Upon completion of the reaction, the reaction mixture was poured into 1N HCl (21 L) and extracted with heptane (2 x 10.5 L). The organic layers were combined, washed with brine, and 1,4-diazabicyclo[2.2.2]octane (740 g) was added. The solution was concentrated to nearly 4 mL/g of alcohol (KF < 200 μg/mL; 2-propanol < 5 vol%). After inoculation at 40°C, the mixture was allowed to cool to room temperature to form crystalline species, which were further cooled to 0°C. The crystalline product was obtained by filtration, washed with cold heptane and dried to give the final DABCO complex in 75-80% yield and ee value >99%.
References
[1] Patent: US2002/22725, 2002, A1
[2] Patent: US2002/52493, 2002, A1
[3] Patent: US2002/52494, 2002, A1
[4] Patent: US6432952, 2002, B1
[5] Patent: US2003/215456, 2003, A1
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Preparation Products And Raw materials
Raw materials
Preparation Products
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Suppliers
- Tel
- --
- Fax
- --
- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL manufacturers
- Product
- 1-(3,5-bis(trifluoromethyl)phenyl)ethanol 368-63-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL 368-63-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL 368-63-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16