ChemicalBook > CAS DataBase List > 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL

Product Name
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
CAS No.
368-63-8
Chemical Name
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
Synonyms
3,5-Bis(trifluoromethyl)phenylethanol;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;(1R)-1-[3,7-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL;ALPHA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol;alpha-methyl-3,5-bis(trifluoromethyl)benzyl alchol;alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol
CBNumber
CB8113483
Molecular Formula
C10H8F6O
Formula Weight
258.16
MOL File
368-63-8.mol
More
Less

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Property

Melting point:
70-74℃
Boiling point:
175.8±35.0 °C(Predicted)
Density 
1.376±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.99±0.20(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
368-63-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2906290090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
T790983
Product name
1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
2802-3-08
Product name
1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity
99.0%
Packaging
1g
Price
$50
Updated
2021/12/16
Apolloscientific
Product number
PC7869
Product name
alpha-Methyl-3,5-bis(trifluoromethyl)benzylalcohol
Purity
99+%
Packaging
1g
Price
$29
Updated
2021/12/16
SynQuest Laboratories
Product number
2802-3-08
Product name
1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity
99.0%
Packaging
5G
Price
$150
Updated
2021/12/16
AK Scientific
Product number
Z4663
Product name
1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
Packaging
5g
Price
$223
Updated
2021/12/16
More
Less

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Chemical Properties,Usage,Production

Synthesis

30071-93-3

7480-35-5

368-63-8

The general procedure for the synthesis of (R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol from 3,5-bis(trifluoromethyl)acetophenone and cis-1-amino-2,3-dihydro-1H-inden-2-ol is as follows: Example 5: To 2-propanol (21 L), [RuCl2 (p-cymene)]2 (18.4 g), (1S,2R)-cis-1-amino-2,3-dihydro-1H-inden-2-ol (9.0 g), and 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (3 kg) were added, stirred for 30 minutes and thoroughly degassed under vacuum. Subsequently, 5M sodium hydroxide solution (28mL) was added and the mixture was aged for 4-6 hours to ensure complete conversion of the feedstock. Upon completion of the reaction, the reaction mixture was poured into 1N HCl (21 L) and extracted with heptane (2 x 10.5 L). The organic layers were combined, washed with brine, and 1,4-diazabicyclo[2.2.2]octane (740 g) was added. The solution was concentrated to nearly 4 mL/g of alcohol (KF < 200 μg/mL; 2-propanol < 5 vol%). After inoculation at 40°C, the mixture was allowed to cool to room temperature to form crystalline species, which were further cooled to 0°C. The crystalline product was obtained by filtration, washed with cold heptane and dried to give the final DABCO complex in 75-80% yield and ee value >99%.

References

[1] Patent: US2002/22725, 2002, A1
[2] Patent: US2002/52493, 2002, A1
[3] Patent: US2002/52494, 2002, A1
[4] Patent: US6432952, 2002, B1
[5] Patent: US2003/215456, 2003, A1

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL Suppliers

Canada 1 China 74 Europe 1 Germany 1 India 4 Switzerland 1 United Kingdom 9 United States 14 Global 105
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2150
Advantage
55
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Cochemical Ltd.
Tel
029-86115547 17791676824
Fax
02151602123
Email
sales@cochemical.com
Country
China
ProdList
3014
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9979
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Changzhou Anxuan Chemical, Co., Ltd.
Tel
13912302692 13912302692;
Fax
0519-88064678
Email
sales@anxuanchem.com
Country
China
ProdList
4828
Advantage
58
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing Hechemist Technology CO.,LTD
Tel
18511709189
Fax
010-58043593
Email
sales@hechemist.com
Country
China
ProdList
2835
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai CR Corporation Limited
Tel
13062833949; 4006653949 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
9757
Advantage
58
Dalian lichuang Chemical Co., Ltd
Tel
0411-0411-00000000 13644282108
Fax
-
Email
3500508746@qq.com
Country
China
ProdList
2896
Advantage
55
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Honest Joy Holdings Limited
Tel
755-36694831 +8613798234863
Email
Linda.zhou@debayer.com
Country
China
ProdList
998
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Baoji Guokang Healthchem Co., Ltd.
Tel
+86-0917-3909592 +86-13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9209
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shandong Territorial sea Biological Technology Co., LTD
Tel
15092083467
Email
18660263263@163.com
Country
China
ProdList
2810
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Shanghai Yao Sen Biotechnology Co., LTD
Tel
021-1367199-5251 13671995251
Email
2648165562@qq.com
Country
China
ProdList
499
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Jiaxing Zhejia Biotechnology Co., LTD
Tel
0573-85609002 18367600069;
Email
zhejia01@163.com
Country
China
ProdList
8886
Advantage
58
Shandong Welt Chem. Co.,Ltd.
Tel
531-87153728 13805401165
Email
xufeng192@126.com
Country
China
ProdList
3964
Advantage
58
Wuhan canos Technology Co., Ltd
Tel
153-37111468 15337111468
Email
385079137@qq.com
Country
China
ProdList
4891
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Heze Bona Medical Technology Co., LTD
Tel
18615487702
Email
614989876@qq.com
Country
China
ProdList
3000
Advantage
58
G-CLONE
Tel
400-910-1997 15330005590
Email
3546414794@qq.com
Country
China
ProdList
9959
Advantage
58
Yanggu Rongke Trading Co., Ltd
Tel
15863541132
Email
18366413387@163.com
Country
China
ProdList
3898
Advantage
58
Jining Yize Pharmaceutical Technology Co., Ltd
Tel
15192473210
Email
302633902@qq.com
Country
China
ProdList
4480
Advantage
58
Xi'an Lechun Chemical Co., Ltd
Tel
029-15596886083 15596886083
Email
739383595@qq.com
Country
China
ProdList
4073
Advantage
58
More
Less

View Lastest Price from 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL manufacturers

Honest Joy Holdings Limited
Product
1-(3,5-bis(trifluoromethyl)phenyl)ethanol 368-63-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99.1%
Supply Ability
100 tons
Release date
2022-02-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL 368-63-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL 368-63-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

368-63-8, 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OLRelated Search:

3,5-Bis(trifluoromethyl)benzyl alcohol 1-[2,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol (R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL

  • 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
  • 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL
  • 3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL
  • ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL
  • alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol
  • 3,5-Bis(trifluoromethyl)phenylethanol
  • alpha-Methyl-3,5-Bis(trifluoromethyl)Benzylalcohol99+%
  • à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol
  • (1R)-1-[3,7-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL
  • ALPHA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL
  • 3-AMINO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE (3-AMINO LACTAM)
  • BenzeneMethanol, a-Methyl-3,5-bis(trifluoroMethyl)-
  • alpha-methyl-3,5-bis(trifluoromethyl)benzyl alchol
  • Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-
  • 1-(3,5-Bis(trifluoromethyl)phenyl)ethanol - [B92884]
  • 368-63-8
  • C10H8F8O
  • PHARMACEUTICAL INTERMEDIATES
  • Aromatic alcohols and diols