ChemicalBook > CAS DataBase List > 6-PHENYL-2-THIOURACIL

6-PHENYL-2-THIOURACIL

Product Name
6-PHENYL-2-THIOURACIL
CAS No.
36822-11-4
Chemical Name
6-PHENYL-2-THIOURACIL
Synonyms
PHENYLTHIOURACIL;BUTTPARK 45\01-77;6-phenylthiouracil;6-PHENYL-2-THIOURACIL;6-Phenyl-2-thiouracil>6-Phenyl-2-thiouracil(4-);6-Phenyl-2-thiouracil ,98%;6-PHENYL-2-THIOURACIL (4-) 98+%;13C,15N2]-6-Phenyl-2-thiouracil;2-Mercapto-6-phenyl-4-pyrimidinol
CBNumber
CB2447915
Molecular Formula
C10H8N2OS
Formula Weight
204.25
MOL File
36822-11-4.mol
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6-PHENYL-2-THIOURACIL Property

Melting point:
263-264.5 °C(Solv: water (7732-18-5))
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Aqueous Base (Slightly), DMSO (Slightly)
form 
Solid
pka
7.29±0.20(Predicted)
color 
White to Off-White
biological source
synthetic (organic)
CAS DataBase Reference
36822-11-4(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P3252
Product name
6-Phenyl-2-thiouracil
Purity
≥95%
Packaging
1g
Price
$233
Updated
2025/07/31
Sigma-Aldrich
Product number
05594
Product name
6-Phenyl-2-thiouracil
Purity
analytical standard
Packaging
100mg
Price
$89.5
Updated
2022/05/15
TCI Chemical
Product number
P0236
Product name
6-Phenyl-2-thiouracil
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$120
Updated
2025/07/31
TCI Chemical
Product number
P0236
Product name
6-Phenyl-2-thiouracil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$360
Updated
2025/07/31
TRC
Product number
P337105
Product name
6-​Phenyl-​2-​thiouracil
Packaging
1g
Price
$305
Updated
2021/12/16
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6-PHENYL-2-THIOURACIL Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

6-Phenyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.

Definition

ChEBI: 6-Phenyl-2-thiouracil is a member of pyrimidines.

Synthesis

94-02-0

17356-08-0

36822-11-4

To a solution of ethyl benzoylacetate (2 g, 10.41 mmol) in ethanol (15 mL) was added sodium ethoxide (7 mL, 18.7 mmol) and compound (CAS:17356-08-0) (1.18 g, 15.61 mmol). The reaction mixture was stirred under reflux conditions overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water, the pH was adjusted to 3 with acid and extracted with ethyl acetate (3 x 20 mL). The organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. The crude product was purified by fast column chromatography using dichloromethane/methanol (2.5%) as eluent to afford 2-mercapto-6-phenyl-4-hydroxypyrimidine (500 mg, 2.44 mmol) as a white solid in 24% yield.

References

[1] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1999, vol. 54, # 6, p. 788 - 798
[2] Synthetic Communications, 2002, vol. 32, # 6, p. 851 - 855
[3] Patent: WO2016/30534, 2016, A1. Location in patent: Page/Page column 109
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 745 - 759
[5] Journal fuer Praktische Chemie (Leipzig), 1893, vol. <2> 47, p. 203

6-PHENYL-2-THIOURACIL Preparation Products And Raw materials

Raw materials

Ethanol Sodium Acetophenone Ethyl acetate Hydrochloric acid Acetic acid Methanol Diethyl carbonate Isopropyl alcohol Thiourea

Preparation Products

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6-PHENYL-2-THIOURACIL Suppliers

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View Lastest Price from 6-PHENYL-2-THIOURACIL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-Phenyl-2-thiouracil 36822-11-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Career Henan Chemical Co
Product
6-PHENYL-2-THIOURACIL 36822-11-4
Price
US $9.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-03

36822-11-4, 6-PHENYL-2-THIOURACILRelated Search:

6-PHENYL-2-THIOURACIL 4-Phenylpyrimidine Uracil 2-Thiouracil 3-(4-OXO-6-PHENYL-1,4-DIHYDRO-PYRIMIDIN-2-YLSULFANYL)-PROPIONIC ACID 2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE (4-OXO-6-PHENYL-1,4-DIHYDRO-PYRIMIDIN-2-YL-SULFANYL)-ACETIC ACID BUTTPARK 14\02-43 N-(2,6-DIMETHYLPHENYL)-2-[(4-OXO-6-PHENYL-1,4-DIHYDROPYRIMIDIN-2-YL)THIO]ACETAMIDE BUTTPARK 14\02-47 4-HYDROXY-6-PHENYL-2-([3-(TRIFLUOROMETHYL)BENZYL]SULFANYL)-5-PYRIMIDINECARBONITRILE 2-[(2-PHENOXYETHYL)THIO]-6-PHENYLPYRIMIDIN-4(1H)-ONE BUTTPARK 13\01-50 BUTTPARK 14\02-41 BUTTPARK 17\09-58 4-HYDROXY-2-(METHYLSULFANYL)-6-PHENYL-5-PYRIMIDINECARBONITRILE 4-HYDROXY-2-(METHYLTHIO)-6-PHENYLPYRIMIDINE BUTTPARK 14\02-45

  • 4-HYDROXY-2-MERCAPTO-6-PHENYLPYRIMIDINE
  • 6-HYDROXY-2-MERCAPTO-4-PHENYLPYRIMIDINE
  • 6-PHENYL-2-THIOURACIL
  • 2-MERCAPTO-6-PHENYL-PYRIMIDIN-4-OL
  • BUTTPARK 45\01-77
  • 6-phenylthiouracil
  • PHENYLTHIOURACIL
  • 6-PHENYL-2-THIOURACIL (4-) 98+%
  • 6-Phenyl-2-thiouracil(4-)
  • 6-Phenyl-2-thiouracil ,98%
  • 1,2-Dihydro-6-phenyl-2-thioxopyrimidine-4(3H)-one
  • 2-Mercapto-6-phenyl-4-pyrimidinol
  • 6-Phenyl-2(1H)-thioxopyrimidine-4(3H)-one
  • 6-Phenyl-2-thioxo-1,2-dihydropyrimidine-4(3H)-one
  • 4-Phenyl-2-mercapto-6-hydroxypyrimidine
  • 2-Mercapto-6-phenylpyriMidin-4-one
  • 2-Mercapto-4-phenyl-6-pyrimidinol
  • 2-mercapto-6-phenylpyrimidin-4(1H)-one(SALTDATA: FREE)
  • 2-Mercapto-4-hydroxy-6-phenylpyriMidine(Ⅰ)
  • 4(1H)-Pyrimidinone, 2,3-dihydro-6-phenyl-2-thioxo-
  • 6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
  • 6-phenyl-2-thioxo-1H-pyrimidin-4-one
  • 6-Phenyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
  • 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • 6-Pyrimidinol, 2-mercapto-4-phenyl-
  • 6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
  • 6-Phenyl-2-thiouracil&gt
  • 13C,15N2]-6-Phenyl-2-thiouracil
  • 6-Phenyl-2-thiouracil in acetonitrile
  • 36822-11-4
  • C10H8N2OS
  • BioChemical
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides