Tolclofos-methyl

ChemicalBook > CAS DataBase List > Tolclofos-methyl

Product Name: Tolclofos-methyl
CAS No.: 57018-04-9
Chemical Name: Tolclofos-methyl
Synonyms: S-3349;RIZOLEX;Basilex;Risolex;Risolex(TM);Tolcofos-methyl;olclofos-methyl;Methyl tolclofo;TOLCLOFOS-METHYL;Methyl tolclofos
CBNumber: CB2451996
Molecular Formula: C9H11Cl2O3PS
Formula Weight: 301.13
MOL File: 57018-04-9.mol

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Tolclofos-methyl Property

Melting point:: 78-80°C
Boiling point:: 338.5±52.0 °C(Predicted)
Density: 1.401±0.06 g/cm3(Predicted)
vapor pressure: 1.84 x 10^-3 (Pa 25 °C)
Flash point:: >100 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
Water Solubility: 1.10 mg l^-1 (25 °C)
Merck: 13,9587
BRN: 2136521
InChIKey: OBZIQQJJIKNWNO-UHFFFAOYSA-N
LogP: 4.560
CAS DataBase Reference: 57018-04-9(CAS DataBase Reference)
NIST Chemistry Reference: Phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester(57018-04-9)
EPA Substance Registry System: Tolclofos-methyl (57018-04-9)

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Safety

Hazard Codes: Xi,N
Risk Statements: 43-50/53
Safety Statements: 22-24/25-61-60-37-24
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: TF0460000
HS Code: 29201900
Hazardous Substances Data: 57018-04-9(Hazardous Substances Data)
Toxicity: LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 31209
Product name: Tolclofos-methyl
Purity: PESTANAL
Packaging: 250mg
Price: $49.56
Updated: 2024/03/01

TRC

Product number: T535265
Product name: Tolclofos-methyl
Packaging: 1g
Price: $215
Updated: 2021/12/16

ChemScene

Product number: CS-5201
Product name: Tolclofos-methyl
Purity: 96.51%
Packaging: 500mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PST0000303
Product name: TOLCLOFOS-METHYL
Purity: 95.00%
Packaging: 5MG
Price: $501.25
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 99597
Product name: Tolclofos-methyl
Packaging: 1g
Price: $575
Updated: 2021/12/16

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Tolclofos-methyl Chemical Properties,Usage,Production

Uses

Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.

Uses

Agricultural fungicide.

Definition

ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.

Metabolic pathway

Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.

Degradation

[¹⁴C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at pH 5, 7 and 9 at 22°C with DT₅₀ values of 139, 417 and 238 days, respectively. Higher temperature led to a more rapid hydrolysis and two hydrolysis products were detected. O-Demethylation and oxidative desulfuration were the major reactions to yield 2,6-dichloro-p-tolyl methyl hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop- tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation with DT₅₀ values of 44 days (in distilled water), 15-28 days (in natural river and pond water) and less than 2 days in 2% acetone/water. The major degradation reactions included oxidative desulfuration to yield compound 3 and O-demethylation to yield compound 2. The major photodegradation products in river and pond waters and soil thinlayer surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6- dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984). In acetone solution, demethylation of the isomerisation product [2,6- dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop- tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl dihydrogen phosphate (8) as the major photodegradates (Mikami et al., 1984).

Toxicity evaluation

Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).

Tolclofos-methyl Preparation Products And Raw materials

Raw materials

Copper Benzyltriethylammonium bromide Chlorine Carbon tetrachloride 2,6-Dichloro-4-methylphenol Methanol White phosphorus

Preparation Products

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Tolclofos-methyl Suppliers

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View Lastest Price from Tolclofos-methyl manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: Tolclofos-methyl 57018-04-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-10-24

57018-04-9, Tolclofos-methylRelated Search:

Bensulfuron methyl Dimethyl sulfoxide N,N-Dimethylformamide Clindamycin phosphate METHYL THIOPHENE-2-CARBOXYLATE Pirimiphos-methyl Dichlorodimethylsilane Tetrakis(hydroxymethyl)phosphonium sulfate Methyl acetate Dimethyl carbonate Dimethyl ether Methylparaben SULPHOSUCCINIC ACID ESTER ETHANE Dimethyl sulfate Kresoxim-methyl Azamethiphos Dimethyl fumarate

2,6-dichloro-4-methylphenyl o,o-dimethyl phosphorothioate

Dimethyl O-(2,6-dichloro-4-methylphenyl) phosphorothioate

S-3349

RIZOLEX

O-(2,6-DICHLORO-4-METHYLPHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE

TOLCLOFOS-METHYL

Basilex

Dichloro-4-methylphenyl-O,O-dimethyl phosphorothioate

o-(2,6-Dichloro-4-methylphenyl) o,o-dimethyl thiophosphate

o-(2,6-dichloro-p-tolyl)o,o-dimethylesterofphosphorothioicacid

O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphate

o,o-dimethylo-(2,6-dichloro-4-methylphenyl)phosphorothioate

Phosphorothioic acid, O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl ester

Phosphorothioicacid,esters,O-(2,6-dichloro-4-methylphenyl)-O,O-dimethylester

phosphorothioicacid,o-(2,6-dichloro-4-methylphenyl)o,o-dimethylester

phosphorothioicacid,o-(2,6-dichloro-p-tolyl)o,o-dimethylester

Risolex

Tolcofos-methyl

BENZTHIAZURON PESTANAL, 100 MG

tolclofos-methyl (bsi,iso)

TOLCHLOFOS-METHYL

O，O-dimethyl-O-(2,6-dichloro-p-tolyl) phosphorothioate

(2,6-Dichloro-4-methylphenoxy)-dimethoxy-sulfanylidenephosphorane

Phosphorothioic acid O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl

Thiophosphoric acid O-(2,6-dichloro-4-methylphenyl)O,O-dimethyl ester

Thiophosphoric acid O,O-dimethyl O-(2,6-dichloro-4-methylphenyl) ester

Thiophosphoric acid=O-(2,6-dichloro-4-methylphenyl)=O,O-dimethyl ester

O-2,6-DICHLORO-P-TOLYLO,O-DIMETHYLPHOSPHOROTHIOATE

Tolclofos-methyl Standard

Tolclofos-methyl Solution, 100ppm

Tolclofos-Methyl 500mg [57018-04-9]

Risolex(TM)

Tolclofos-methyl Solution, 1000ppm

Tolclofos-methyl@1000 μg/mL in Acetone

Tolclofos-methyl @100 μg/mL in MeOH

Tolchlophos-methyl

Tolclofos-MethylStock,100mg/L,1ml

olclofos-methyl

TIANFU-CHEM - Tolclofos-methyl

Methyl tolclofo

Methyl tolclofos

Tolclofos-methyl Solution in Methanol

Tolclofos-methyl Solution in Hexane

57018-04-9

C9H11Cl2O3PS

FUNGICIDE