Tolclofos-methyl

ChemicalBook > CAS DataBase List > Tolclofos-methyl

Product Name: Tolclofos-methyl
CAS No.: 57018-04-9
Chemical Name: Tolclofos-methyl
Synonyms: S-3349;RIZOLEX;Basilex;Risolex;Risolex(TM);Tolcofos-methyl;olclofos-methyl;Methyl tolclofo;TOLCLOFOS-METHYL;Methyl tolclofos
CBNumber: CB2451996
Molecular Formula: C9H11Cl2O3PS
Formula Weight: 301.13
MOL File: 57018-04-9.mol

Less

Tolclofos-methyl Property

Melting point:: 78-80°C
Boiling point:: 338.5±52.0 °C(Predicted)
Density: 1.401±0.06 g/cm3(Predicted)
vapor pressure: 1.84 x 10^-3 (Pa 25 °C)
Flash point:: >100 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
Water Solubility: 1.10 mg l^-1 (25 °C)
color: White to off-white
Merck: 13,9587
BRN: 2136521
InChIKey: OBZIQQJJIKNWNO-UHFFFAOYSA-N
LogP: 4.560
CAS DataBase Reference: 57018-04-9(CAS DataBase Reference)
NIST Chemistry Reference: Phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester(57018-04-9)
EPA Substance Registry System: Tolclofos-methyl (57018-04-9)

Less

Safety

Hazard Codes: Xi,N
Risk Statements: 43-50/53
Safety Statements: 22-24/25-61-60-37-24
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: TF0460000
HS Code: 29201900
Hazardous Substances Data: 57018-04-9(Hazardous Substances Data)
Toxicity: LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 31209
Product name: Tolclofos-methyl
Purity: PESTANAL
Packaging: 250mg
Price: $49.56
Updated: 2024/03/01

TRC

Product number: T535265
Product name: Tolclofos-methyl
Packaging: 1g
Price: $215
Updated: 2021/12/16

ChemScene

Product number: CS-5201
Product name: Tolclofos-methyl
Purity: 96.51%
Packaging: 500mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PST0000303
Product name: TOLCLOFOS-METHYL
Purity: 95.00%
Packaging: 5MG
Price: $501.25
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 99597
Product name: Tolclofos-methyl
Packaging: 1g
Price: $575
Updated: 2021/12/16

Less

Tolclofos-methyl Chemical Properties,Usage,Production

Uses

Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.

Uses

Agricultural fungicide.

Definition

ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.

Metabolic pathway

Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.

Degradation

[¹⁴C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at pH 5, 7 and 9 at 22°C with DT₅₀ values of 139, 417 and 238 days, respectively. Higher temperature led to a more rapid hydrolysis and two hydrolysis products were detected. O-Demethylation and oxidative desulfuration were the major reactions to yield 2,6-dichloro-p-tolyl methyl hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop- tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation with DT₅₀ values of 44 days (in distilled water), 15-28 days (in natural river and pond water) and less than 2 days in 2% acetone/water. The major degradation reactions included oxidative desulfuration to yield compound 3 and O-demethylation to yield compound 2. The major photodegradation products in river and pond waters and soil thinlayer surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6- dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984). In acetone solution, demethylation of the isomerisation product [2,6- dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop- tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl dihydrogen phosphate (8) as the major photodegradates (Mikami et al., 1984).

Toxicity evaluation

Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).

Tolclofos-methyl Preparation Products And Raw materials

Raw materials

Copper Benzyltriethylammonium bromide Chlorine Carbon tetrachloride 2,6-Dichloro-4-methylphenol Methanol White phosphorus

Preparation Products

Less

Tolclofos-methyl Suppliers

Canada 1 China 135 France 2 Germany 2 India 1 Japan 2 South Korea 1 Switzerland 1 United Kingdom 4 United States 21 Global 170

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6116
Advantage: 58

Guangzhou Kafen Biotech Co.,Ltd

Tel: 18029243487 2355327168
Fax: 020-31121510
Email: gy@yccreate.com
Country: China
ProdList: 4749
Advantage: 55

Wuhai Shuou Technology Co., Ltd.

Tel: 17792809151
Fax: 18872220797
Email: 2355916837@ycphar.com
Country: China
ProdList: 6133
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9374
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15497
Advantage: 58

Foshan DaoQi Biological Co., Ltd.

Tel: 18062666947
Fax: 18062666959
Email: 2355880548@qq.com
Country: China
ProdList: 4228
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Beijing altar ink quality inspection technology co., LTD

Tel: 010-52889049
Email: 2250970673@qq.com
Country: CHINA
ProdList: 1132
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel
Country: China
ProdList: 11664
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8617531153977
Email: allison@yan-xi.com
Country: China
ProdList: 5857
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17365
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

shanghai Chemsoon Co. Ltd.

Tel: 021-51987688-803
Fax: 021-33321556
Email: sales@chemsoon.com
Country: China
ProdList: 840
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39894
Advantage: 58

Wuhan Rongcan Biotechnology Co., Ltd

Tel: 18327024450
Fax: 183-27024450
Email: 2130026275@qq.com
Country: China
ProdList: 4571
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038; 18501792038
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9611
Advantage: 58

Wuhan kemike Biomedical Technology Co., Ltd

Tel: 13163388153 13163388153
Email: yeqiu416@163.com
Country: China
ProdList: 9884
Advantage: 58

Shanghai Sig Biotechnology Co., LTD

Tel: 021-57810052 18930344717
Fax: 021-57810052
Email: 2089316240@qq.com
Country: China
ProdList: 9395
Advantage: 58

Wuhan plov Biotechnology Co., Ltd

Tel: 17612776928
Fax: 17612776928
Email: 17612776928@qq.com
Country: China
ProdList: 4971
Advantage: 58

Hubei MAX Fine Chemical Technology Co., Ltd.

Tel: 13026126800 13027176014
Fax: QQ1652805836
Email: hbmaxkj@163.com
Country: China
ProdList: 4728
Advantage: 58

Chongqing Yuanyuanxiang Technology Development Co. LTD

Tel: 023-55703781 15320534687
Fax: 023-55703781
Email: 2022434087@qq.com
Country: China
ProdList: 4100
Advantage: 58

Wuhan Hongde Yuexin Pharmatech Co.,Ltd

Tel: 027-83855396 15271852016
Fax: 027-83855396
Email: whhdyxchem@sina.com
Country: China
ProdList: 1114
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

ChengDu SinoStandards Bio-Tech Co.,Ltd. ，

Tel: 028-83243028 19136088901
Email: sinostandards@163.com
Country: China
ProdList: 4985
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10011
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9950
Advantage: 58

Less

View Lastest Price from Tolclofos-methyl manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Tolclofos-methyl 57018-04-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

57018-04-9, Tolclofos-methylRelated Search:

Bensulfuron methyl Dimethyl sulfoxide N,N-Dimethylformamide Clindamycin phosphate METHYL THIOPHENE-2-CARBOXYLATE Pirimiphos-methyl Dichlorodimethylsilane Tetrakis(hydroxymethyl)phosphonium sulfate Methyl acetate Dimethyl carbonate Dimethyl ether Methylparaben SULPHOSUCCINIC ACID ESTER ETHANE Dimethyl sulfate Kresoxim-methyl Azamethiphos Dimethyl fumarate

2,6-dichloro-4-methylphenyl o,o-dimethyl phosphorothioate

Dimethyl O-(2,6-dichloro-4-methylphenyl) phosphorothioate

S-3349

RIZOLEX

O-(2,6-DICHLORO-4-METHYLPHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE

TOLCLOFOS-METHYL

Basilex

Dichloro-4-methylphenyl-O,O-dimethyl phosphorothioate

o-(2,6-Dichloro-4-methylphenyl) o,o-dimethyl thiophosphate

o-(2,6-dichloro-p-tolyl)o,o-dimethylesterofphosphorothioicacid

O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphate

o,o-dimethylo-(2,6-dichloro-4-methylphenyl)phosphorothioate

Phosphorothioic acid, O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl ester

Phosphorothioicacid,esters,O-(2,6-dichloro-4-methylphenyl)-O,O-dimethylester

phosphorothioicacid,o-(2,6-dichloro-4-methylphenyl)o,o-dimethylester

phosphorothioicacid,o-(2,6-dichloro-p-tolyl)o,o-dimethylester

Risolex

Tolcofos-methyl

BENZTHIAZURON PESTANAL, 100 MG

tolclofos-methyl (bsi,iso)

TOLCHLOFOS-METHYL

O，O-dimethyl-O-(2,6-dichloro-p-tolyl) phosphorothioate

(2,6-Dichloro-4-methylphenoxy)-dimethoxy-sulfanylidenephosphorane

Phosphorothioic acid O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl

Thiophosphoric acid O-(2,6-dichloro-4-methylphenyl)O,O-dimethyl ester

Thiophosphoric acid O,O-dimethyl O-(2,6-dichloro-4-methylphenyl) ester

Thiophosphoric acid=O-(2,6-dichloro-4-methylphenyl)=O,O-dimethyl ester

O-2,6-DICHLORO-P-TOLYLO,O-DIMETHYLPHOSPHOROTHIOATE

Tolclofos-methyl Standard

Tolclofos-methyl Solution, 100ppm

Tolclofos-Methyl 500mg [57018-04-9]

Risolex(TM)

Tolclofos-methyl Solution, 1000ppm

Tolclofos-methyl@1000 μg/mL in Acetone

Tolclofos-methyl @100 μg/mL in MeOH

Tolchlophos-methyl

Tolclofos-MethylStock,100mg/L,1ml

olclofos-methyl

TIANFU-CHEM - Tolclofos-methyl

Methyl tolclofo

Methyl tolclofos

Tolclofos-methyl Solution in Methanol

Tolclofos-methyl Solution in Hexane

Tolclofos-methyl-d6 (O,O-dimethyl-d6) in methanol

Tolclofos Methyl in Acetone

Tolclofos Methyl in Methanol

C17590000 Tolclofos-methyl

L17590000CY Tolclofos-methyL10μg/mLin Cycloh

Tolclofos-methyl 10.0 μg/ml Ethyl acetate

Tolclofos-methyl 100 μg/ml Acetonitrile

Tolclofos-methyl 100 μg/ml Toluene

57018-04-9

C9H11Cl2O3PS

FUNGICIDE