ChemicalBook > CAS DataBase List > Quinine hydrochloride

Quinine hydrochloride

Product Name
Quinine hydrochloride
CAS No.
130-89-2
Chemical Name
Quinine hydrochloride
Synonyms
QUININE HC;QUININE HCL;chinimetten;quininemuriate;quininechloride;Quinine Impurity 11;Quinine hydrochlorid;QUININE HYDROCHLORIDE;Quinine HCL & Sulfate;QUININE HCL USP/EP/BP
CBNumber
CB2453521
Molecular Formula
C20H25ClN2O2
Formula Weight
360.88
MOL File
130-89-2.mol
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Quinine hydrochloride Property

Melting point:
158-160 C
Density 
1.1206 (rough estimate)
refractive index 
1.5400 (estimate)
FEMA 
2976 | QUININE HYDROCHLORIDE
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Ethanol (1g/1ml), glycerol(1g/7ml), chloroform(1g/1ml)
form 
Solid
color 
White
Water Solubility 
549.7mg/L(25 ºC)
InChI
InChI=1/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19-,20+;/s3
InChIKey
LBSFSRMTJJPTCW-QJLYHTAINA-N
SMILES
C12C=C(C=CC=1N=CC=C2[C@@H](O)[C@]1([H])C[C@]2([H])CCN1C[C@@H]2C=C)OC.Cl |&1:10,12,15,21,r|
LogP
3.496 (est)
EPA Substance Registry System
Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)- (130-89-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29392000
Toxicity
cat,LDLo,intravenous,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
4114
Product name
Quininehydrochloride
Packaging
50
Price
$53
Updated
2021/12/16
TRC
Product number
Q694020
Product name
QuinineHydrochloride
Packaging
50mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
256384
Product name
Quinine hydrochloride
Packaging
50mg
Price
$267
Updated
2021/12/16
AK Scientific
Product number
I951
Product name
QuinineHCl
Packaging
1g
Price
$14
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024401
Product name
QUININE HYDROCHLORIDE
Purity
95.00%
Packaging
10G
Price
$179.55
Updated
2021/12/16
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Quinine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.

Uses

Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

Definition

Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.

Biological Activity

Quinine hydrochloride is a displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine; closely related to chloroquine.?

Safety Profile

Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.

Synthesis

Manufacture of quinine by extraction from Cinchona bark and subsequent purification and synthesis to quinine hydrochloride.

target

Adrenergic Receptor

storage

Store at -20°C

Quinine hydrochloride Preparation Products And Raw materials

Raw materials

Cinchona ledgeriana bark Quinine

Preparation Products

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View Lastest Price from Quinine hydrochloride manufacturers

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
Product
Quinine Hydrochloride 130-89-2
Price
US $0.00/kg
Min. Order
25kg
Purity
99% BP/USP/EP
Supply Ability
20000
Release date
2024-11-08
Hebei Weibang Biotechnology Co., Ltd
Product
QUININE HCL 130-89-2
Price
US $10.00-8.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
Quinine hydrochloride 130-89-2
Price
US $20.00-15.00/kg
Min. Order
1kg
Purity
99.5（%）
Supply Ability
5000kg/month
Release date
2024-03-27

130-89-2, Quinine hydrochlorideRelated Search:

Quinidine Cinchonidine Quinine sulfate dihydrate Quinine Quinine dihydrochloride N-BENZYLQUININIUM CHLORIDE Quinine QUININE HCL QUININE HCL / DIHCL / SULFATE Quinine HCl medical grade QUININE HCL USP(CRM STANDARD) Quinine hydrochloride QUININE HCL NON-KOSHER 6-METHOXYCINCHONINE UREA HYDROCHLORIDE togal

  • QUININE HCL
  • QUININE HYDROCHLORIDE
  • QUININE MONOHYDROCHLORIDE
  • 6’-methoxy-,monohydrochloride,(8.alpha.,9R)-Cinchonan-9-ol
  • 6’-methoxy-,monohydrochloride,(8-alpha,9r)-cinchonan-9-o
  • 6’-methoxy-,monohydrochloride,(8alpha,9theta)-cinchonan-9-o
  • chinimetten
  • quininechloride
  • quininemuriate
  • Hydrochloric acid quinine
  • Quinine·hydrochloric acid
  • Quinine HCL & Sulfate
  • Cinchonan-9-ol,6'-Methoxy-, hydrochloride (1:1), (8alpha,9R)-
  • (8alpha,9R)-6'-methoxycinchonan-9-ol monohydrochloride
  • QUININE HYDROCHLORIDE 2 H2O
  • Cinchonan-9-ol, 6-methoxy-, monohydrochloride, (8.alpha.,9R)-
  • Cinchonan-9-ol, 6'-methoxy-, monohydrochloride, (8a,9R)- (9CI)
  • Quinine, monohydrochloride (8CI)
  • (R)-[(4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol:hydrochloride
  • Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8α,9R)-
  • Quinine Hydrochloride HCL
  • QUININE HCL USP/EP/BP
  • (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride
  • Quinine hydrochlorid
  • (R)-[(2S，4S，5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol hydrochloride
  • QUININE HC
  • Quinine Impurity 11
  • Cyproconazole Impurity 3
  • 130-89-2
  • C10H24N2O22H2O
  • C20H24N2O2HCl
  • C20H25N2O2Cl