Quinine hydrochloride

Product Name: Quinine hydrochloride
CAS No.: 130-89-2
Chemical Name: Quinine hydrochloride
Synonyms: QUININE HC;QUININE HCL;chinimetten;quininemuriate;quininechloride;Quinine Impurity 11;Quinine hydrochlorid;QUININE HYDROCHLORIDE;Quinine HCL & Sulfate;QUININE HCL USP/EP/BP
CBNumber: CB2453521
Molecular Formula: C20H25ClN2O2
Formula Weight: 360.88
MOL File: 130-89-2.mol

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Quinine hydrochloride Property

Melting point:: 158-160 C
Density: 1.1206 (rough estimate)
refractive index: 1.5400 (estimate)
FEMA: 2976 | QUININE HYDROCHLORIDE
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Ethanol (1g/1ml), glycerol(1g/7ml), chloroform(1g/1ml)
form: Solid
color: White
Water Solubility: 549.7mg/L(25 ºC)
InChI: InChI=1/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19-,20+;/s3
InChIKey: LBSFSRMTJJPTCW-QJLYHTAINA-N
SMILES: C12C=C(C=CC=1N=CC=C2[C@@H](O)[C@]1([H])C[C@]2([H])CCN1C[C@@H]2C=C)OC.Cl |&1:10,12,15,21,r|
LogP: 3.496 (est)
EPA Substance Registry System: Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)- (130-89-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29392000
Toxicity: cat,LDLo,intravenous,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 4114
Product name: Quininehydrochloride
Packaging: 50
Price: $53
Updated: 2021/12/16

TRC

Product number: Q694020
Product name: QuinineHydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 256384
Product name: Quinine hydrochloride
Packaging: 50mg
Price: $267
Updated: 2021/12/16

AK Scientific

Product number: I951
Product name: QuinineHCl
Packaging: 1g
Price: $14
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024401
Product name: QUININE HYDROCHLORIDE
Purity: 95.00%
Packaging: 10G
Price: $179.55
Updated: 2021/12/16

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Quinine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.

Uses

Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

Definition

Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.

Biological Activity

Quinine hydrochloride is a displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine; closely related to chloroquine.?

Safety Profile

Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.

Synthesis

Manufacture of quinine by extraction from Cinchona bark and subsequent purification and synthesis to quinine hydrochloride.

target

Adrenergic Receptor

storage

Store at -20°C

Quinine hydrochloride Preparation Products And Raw materials

Raw materials

Cinchona ledgeriana bark Quinine

Preparation Products

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Quinine hydrochloride Suppliers

Belgium 1 China 131 Europe 1 France 1 Germany 2 India 27 United Kingdom 4 United States 13 USA 1 Global 181

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View Lastest Price from Quinine hydrochloride manufacturers

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

Product: Quinine Hydrochloride 130-89-2
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99% BP/USP/EP
Supply Ability: 20000
Release date: 2024-11-08

Hebei Weibang Biotechnology Co., Ltd

Product: QUININE HCL 130-89-2
Price: US $10.00-8.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: Quinine hydrochloride 130-89-2
Price: US $20.00-15.00/kg
Min. Order: 1kg
Purity: 99.5（%）
Supply Ability: 5000kg/month
Release date: 2024-03-27

130-89-2, Quinine hydrochlorideRelated Search:

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QUININE MONOHYDROCHLORIDE

6’-methoxy-,monohydrochloride,(8.alpha.,9R)-Cinchonan-9-ol

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quininemuriate

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Quinine Hydrochloride HCL

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Quinine hydrochlorid

(R)-[(2S，4S，5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol hydrochloride

QUININE HC

Quinine Impurity 11

Cyproconazole Impurity 3

130-89-2

C10H24N2O22H2O

C20H24N2O2HCl

C20H25N2O2Cl