P-TOLUENESULFONYL FLUORIDE Property

Melting point:

41-42 °C(lit.)

Boiling point:

112 °C16 mm Hg(lit.)

Density 

1.2768 (estimate)

Flash point:

222 °F

Water Solubility 

Hydrolyzes in water.

Sensitive 

Moisture Sensitive

BRN 

2208423

Exposure limits

ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3

CAS DataBase Reference

455-16-3(CAS DataBase Reference)

EPA Substance Registry System

Benzenesulfonyl fluoride, 4-methyl- (455-16-3)

Safety

Hazard Codes 

C

Risk Statements 

20/21/22-34

Safety Statements 

22-26-27-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

RTECS 

XT8050000

Hazard Note 

Corrosive

TSCA 

T

HazardClass 

8

PackingGroup 

II

HS Code 

29049095

Toxicity

rat,LD50,intraperitoneal,200mg/kg (200mg/kg),Nature. Vol. 173, Pg. 33, 1954.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P-TOLUENESULFONYL FLUORIDE Chemical Properties,Usage,Production

Chemical Properties

White to beige fused mass

Uses

p-Toluenesulfonyl fluoride is used for sulfonylation of organometallic reagents as a simple, one-step synthesis of sulfones. It is useful in the treatment of Alzheimer?s disease. It is used to study the DNS polymerase from spinach leaf extracts. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation.

Uses

Protease inhibitor.

General Description

p-Toluenesulfonyl fluoride is a peroxygen bleach activator and is also useful in the treatment of Alzheimer′s disease.