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(+/-)-NICOTINE

Product Name
(+/-)-NICOTINE
CAS No.
22083-74-5
Chemical Name
(+/-)-NICOTINE
Synonyms
NICOTINE;(r,s)-nicotine;rac-Nicotine;1-METHYL-2-(3-PYRIDYL)PYRROLIDINE;Nicotine for system suitability CRS;dl-nicotine;(+-)-pyridin;(+-)-nicotin;BLACK LEAF 40;(+/-)-NICOTINE
CBNumber
CB2459639
Molecular Formula
C10H14N2
Formula Weight
162.23
MOL File
22083-74-5.mol
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(+/-)-NICOTINE Property

Melting point:
-79 °C
Boiling point:
67°C/0.5 mm
Density 
1.02 g/mL at 25 °C(lit.)
Flash point:
101 °C
storage temp. 
Refrigerator
solubility 
ethanol: 50 mg/mL
form 
liquid
pka
8.02(at 25℃)
color 
yellow
optical activity
[α]25/D 0°(lit.)
BRN 
82108
Stability:
Air Sensitive
CAS DataBase Reference
22083-74-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T+,N
Risk Statements 
25-27-51/53
Safety Statements 
36/37-45-61
RIDADR 
UN 1654 6.1/PG 2
WGK Germany 
3
RTECS 
QS5257500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N0267
Product name
(±)-Nicotine
Purity
≥99% (TLC), liquid
Packaging
100mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
N0267
Product name
(±)-Nicotine
Purity
≥99% (TLC), liquid
Packaging
1g
Price
$756
Updated
2024/03/01
Cayman Chemical
Product number
16535
Product name
(±)-Nicotine
Purity
≥98%
Packaging
100mg
Price
$101
Updated
2024/03/01
Cayman Chemical
Product number
16535
Product name
(±)-Nicotine
Purity
≥98%
Packaging
250mg
Price
$177
Updated
2024/03/01
Sigma-Aldrich
Product number
N0267
Product name
(±)-Nicotine
Purity
≥99% (TLC), liquid
Packaging
500mg
Price
$411
Updated
2024/03/01
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(+/-)-NICOTINE Chemical Properties,Usage,Production

Chemical Properties

(+/-)-NICOTINE is Colourless Liquid

Uses

This is the unnatural isomer of Nicotine

Uses

(+/-)-NICOTINE is an alkaloid isolated from plants. It is an active stimulant, having both addictive and carcinogenic properties.

Uses

Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tra ct and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.

Definition

ChEBI: 3-(1-methylpyrrolidin-2-yl)pyridine is an N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. It is a N-alkylpyrrolidine, a pyridine alkaloid and a pyrrolidine alkaloid.

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist.

Purification Methods

(+/-)-NICOTINE is purified by fractional distillation. Its solubility in EtOH is ~5%. The picrate forms yellow needles from hot H2O and has m 219o. The methiodide has m 219o (from MeOH). [Craig J Am Chem Soc 55 2854 1933, Nakane & Hutchinson J Org Chem 43 3922 1978, Beilstein 23/6 V 64.] POISONOUS.

(+/-)-NICOTINE Preparation Products And Raw materials

Raw materials

CALCIUM CARBONATE

Preparation Products

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(+/-)-NICOTINE Suppliers

Canada 3 China 74 Europe 2 France 1 Germany 1 India 6 Switzerland 1 United Kingdom 4 United States 12 Global 104
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View Lastest Price from (+/-)-NICOTINE manufacturers

Shanghai Standard Technology Co., Ltd.
Product
(±)-Nicotine 22083-74-5
Price
US $0.00/ml
Min. Order
0.1ml
Purity
≥98%(HPLC)
Supply Ability
100 ml
Release date
2020-05-25

22083-74-5, (+/-)-NICOTINERelated Search:

Nicotinic acid Nicotinamide NICOTINE BI-L-(+)-TARTRATE DL-Nicotine-d3 (methyl-d3),TRIDEUTEROMETHYL-NICOTINE,dl-nicotine-methyl-d3,nicotine-d3(methyl-d3) (-)-NICOTINE D-(+)-HYDROGEN TARTRATE (Nicotine Metabolite) Nicotine (+/-)-COTININE-D3 (+/-)-NICOTINE (-)-COTININE NICOTINE SALICYLATE Nicotine Sulfate (40-45% in Water as Nicotine base) (+)-NICOTINE-(+)-DI-P-TOLUOYL TARTRATE NICOTINE, L-, [N-METHYL-3H] rac trans-4-Cotininecarboxylic Acid NICOTINE, D [N-METHYL 14C] (+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT NICOTINE, DL-, [N-METHYL-3H]

  • 1-METHYL-2-(3-PYRIDYL)PYRROLIDINE
  • BLACK LEAF 40
  • (+/-)-NICOTINE
  • NICOTINE
  • (r,s)-nicotine
  • 3-(1-methyl-2-pyrrolidinyl)-pyridin
  • 3-(1-methyl-pyrrolidin-2-yl)-pyridine
  • rac-Nicotine
  • (±)-Nicotine-d7
  • (+-)-nicotin
  • (+-)-pyridin
  • (+)-3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine
  • (2R)-1-Methyl-2-(3-pyridyl)pyrrolidine
  • 3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine
  • dl-beta-nicotine
  • dl-nicotine
  • (-)-1-Methyl-2-[3-pyridyl]pyrrolidine, free base
  • R-(+)-Nicotine, [+]-1-Methyl-2-[3-pyridyl]pyrrolidine, Free Base
  • NICOTINE ALKALOID 95%
  • NICOTINE ALKALOID USP
  • DL-Nicotine-d3 (N-methyl-d3)
  • Nicotine salts: (d1-beta-Nicotine: DL-Nicotine)
  • Nicotine for system suitability CRS
  • (+/-)-NICOTINE USP/EP/BP
  • (+/-)-NICOTINE
  • Acrylamide Impurity 19
  • 22083-74-5
  • Ligand-Gated Ion Channels
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Nicotinic Acetylcholine Receptor Modulators
  • Ion Channels
  • AgonistsIon Channels
  • Cholinergics
  • Ligand-Gated Ion Channels
  • Neurotransmitters
  • Nicotinic Acetylcholine Receptor Modulators
  • Nicotine Derivatives
  • Neurochemicals