(+/-)-NICOTINE Property

Melting point:

-79 °C

Boiling point:

67°C/0.5 mm

Density 

1.02 g/mL at 25 °C(lit.)

Flash point:

101 °C

storage temp. 

Refrigerator

solubility 

ethanol: 50 mg/mL

form 

liquid

pka

8.02(at 25℃)

color 

yellow

optical activity

[α]25/D 0°(lit.)

BRN 

82108

Stability:

Air Sensitive

CAS DataBase Reference

22083-74-5(CAS DataBase Reference)

Safety

Hazard Codes 

T+,N

Risk Statements 

25-27-51/53

Safety Statements 

36/37-45-61

RIDADR 

UN 1654 6.1/PG 2

WGK Germany 

3

RTECS 

QS5257500

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

(+/-)-NICOTINE Chemical Properties,Usage,Production

Chemical Properties

(+/-)-NICOTINE is Colourless Liquid

Uses

This is the unnatural isomer of Nicotine

Uses

(+/-)-NICOTINE is an alkaloid isolated from plants. It is an active stimulant, having both addictive and carcinogenic properties.

Uses

Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tra ct and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.

Definition

ChEBI: 3-(1-methylpyrrolidin-2-yl)pyridine is an N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. It is a N-alkylpyrrolidine, a pyridine alkaloid and a pyrrolidine alkaloid.

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist.

Purification Methods

(+/-)-NICOTINE is purified by fractional distillation. Its solubility in EtOH is ~5%. The picrate forms yellow needles from hot H2O and has m 219o. The methiodide has m 219o (from MeOH). [Craig J Am Chem Soc 55 2854 1933, Nakane & Hutchinson J Org Chem 43 3922 1978, Beilstein 23/6 V 64.] POISONOUS.