4-Methyl-5-nitroimidazole Property

Melting point:

249 °C (lit.)

Boiling point:

235.85°C (rough estimate)

Density 

1.4748 (rough estimate)

refractive index 

1.5000 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Sparingly), Methanol (Slightly, Sonicated)

pka

8.74±0.10(Predicted)

form 

Powder or Crystalline Powder

color 

White to light brown

InChIKey

WSYOWIMKNNMEMZ-UHFFFAOYSA-N

NIST Chemistry Reference

Imidazole, 4-methyl-5-nitro-(14003-66-8)

EPA Substance Registry System

1H-Imidazole, 4-methyl-5-nitro- (14003-66-8)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

NI7562000

HS Code 

2933299090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Methyl-5-nitroimidazole Chemical Properties,Usage,Production

Uses

5-Methyl-4-nitroimidazole can cause mutations with Klebsiella pneumonia and Salmonella typhimurium.

Uses

5-Methyl-4-nitroimidazole may be used in the following:

• To trap the reactive 1:1 intermediate formed during the reaction between triphenylphosphine and dibenzoylacetylene.
• As a starting reagent in the synthesis of pyrazole derivatives.
• Fabrication of zeolitic imidazolate frameworks (ZIFs).

General Description

5-Methyl-4-nitroimidazole, an imidazole derivative, is a heterocyclic NH-acid. Its nitration in the presence of acetic anhydride/glacial acetic acid has been studied.