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1-NAPHTHOHYDROXAMIC ACID

Product Name
1-NAPHTHOHYDROXAMIC ACID
CAS No.
6953-61-3
Chemical Name
1-NAPHTHOHYDROXAMIC ACID
Synonyms
NSC 57457;Naphthohydroxamicacid;a-Naphthohydroxamic acid;1-NAPHTHOHYDROXAMIC ACID;1-NaphthohydroxamicAcid>alpha-naphthohydroxamicacid;1-NAPHTHOHYDROXAMIC ACID 98+%;HDAC Inhibitor XIX, Compound 2;n-hydroxy-1-naphthalenecarboxamid;1-Naphthalenecarbohydroximic acid
CBNumber
CB2462406
Molecular Formula
C11H9NO2
Formula Weight
187.19
MOL File
6953-61-3.mol
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1-NAPHTHOHYDROXAMIC ACID Property

Melting point:
176-178 °C
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
pka
8.91±0.30(Predicted)
form 
White solid
color 
white to tan
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Safety

Risk Statements 
52
WGK Germany 
3
RTECS 
QJ1894500
HS Code 
2928009090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382177
Product name
HDAC Inhibitor XIX, Compound 2
Packaging
50mg
Price
$110
Updated
2023/01/07
TCI Chemical
Product number
N0023
Product name
1-Naphthohydroxamic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$375
Updated
2024/03/01
TRC
Product number
N369018
Product name
1-Naphthohydroxamic Acid
Packaging
5mg
Price
$55
Updated
2021/12/16
ChemScene
Product number
CS-0108907
Product name
1-Naphthohydroxamic Acid
Purity
>98.0%
Packaging
5mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-0108907
Product name
1-Naphthohydroxamic Acid
Purity
>98.0%
Packaging
10mg
Price
$120
Updated
2021/12/16
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1-NAPHTHOHYDROXAMIC ACID Chemical Properties,Usage,Production

Uses

1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.

Biochem/physiol Actions

1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.

1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6953-61-3, 1-NAPHTHOHYDROXAMIC ACIDRelated Search:

Pyrazine 2-Naphthohydroxamic acid, O-acetate ester Naftalofos N-HYDROXYNAPHTHALIMIDE SODIUM SALT N-Hydroxy-1,8-naphthalimide Naphthaloximidodiethyl thiophosphate N-Hydroxynaphthalimide triflate 1-NAPHTHOHYDROXAMIC ACID

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