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ANTI-CD137

Product Name
ANTI-CD137
Chemical Name
ANTI-CD137
Synonyms
ANTI-4-1BB;ANTI-CD137;ANTI-HUMAN CD137;ANTI-HUMAN 4-1BB;ANTI-4-1BB (HUMAN);ANTI-CD137 (HUMAN);ANTI-TNFRSF 9 (HUMAN);ANTI-HUMAN CDW137 (4-1BB);ANTI-CD137 (4-1BB), HUMAN;ANTI-4-1BB (140-155), MOUSE (RABBIT)
CBNumber
CB2463610
Formula Weight
0
MOL File
Mol file
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ANTI-CD137 Property

storage temp. 
−20°C
form 
lyophilized powder
biological source
goat
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0730
Product name
Anti-CD137 antibody produced in goat
Purity
affinity isolated antibody, lyophilized powder
Packaging
0.1mg
Price
$410.2
Updated
2025/07/31
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ANTI-CD137 Chemical Properties,Usage,Production

Uses

Anti-CD137 antibody produced in goat is suitable for the following applications:

  • Agonist Activity: Measured by its ability to costimulate IFNg secretion by human T cells in the presence of anti-CD3. The ED50 for this effect is typically 5-20μg/mL.
  • ELISA capture: It can be used as a capturing reagent in a human 4-1BB sandwich immunoassay in combination with biotinylated human 4-1BB detection antibody and recombinant human 4-1BB as the standard. The suggested coating concentration range is 0.2-0.8μg/ml. The recommended concentration of the detection antibody is 0.1-0.4μg/mL.
  • Flow cytometry: 2.5μg/106 cells using Human T cells treated with PHA (phytohemagglutinin).
  • Immunoblotting: A working concentration of 0.1μg/ml was determined using recombinant human CD137.
  • Immunocytochemistry: 5-15μg/mL using immersion fixed human peripheral blood mononuclear cells.

General Description

CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes.

Biochem/physiol Actions

CD137 in T lymphocytes helps to regulate activation, proliferation and apoptosis. CD137 and CD28 are co-stimulatory molecules of T cell activation. It plays an important role in regulating T-cell-dependent immune responses. The expression of CD137 correlates negatively with lymphocyte proliferation and induces cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and helps in prolongs survival.

ANTI-CD137 Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTI-CD137 Suppliers

CHINA 9 Switzerland 2 United Kingdom 1 United States 5 Global 17
Shanghai Bohu Biotechnology Co., LTD
Tel
021-57763112 13585886131
Email
3004987436@qq.com
Country
China
ProdList
9692
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58
Biolab Reagents
Tel
027-65279366 18108604356
Email
products@biolabreagent.com
Country
China
ProdList
9868
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58
ACROBiosystems
Tel
13121935750
Email
jiaxin.zhao@acrobiosystems.com
Country
China
ProdList
1354
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58

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  • Anti-CD137 antibody produced in goat
  • ANTI-4-1BB (140-155), MOUSE (RABBIT)
  • ANTI-4-1BB
  • ANTI-4-1BB (HUMAN)
  • ANTI-CD137
  • ANTI-CD137 (4-1BB), HUMAN
  • ANTI-CD137 (HUMAN)
  • ANTI-HUMAN 4-1BB
  • ANTI-HUMAN CD137
  • ANTI-HUMAN CDW137 (4-1BB)
  • ANTI-TNFRSF 9 (HUMAN)