Tauro--muricholic Acid (sodium salt)
- Product Name
- Tauro--muricholic Acid (sodium salt)
- CAS No.
- 145022-92-0
- Chemical Name
- Tauro--muricholic Acid (sodium salt)
- Synonyms
- T-βMCA sodium;Tauro-β-muricholic acid sodium;Tauro-β-muricholic Acid sodium salt;Tauro-muricholic Acid (sodium salt);D4-Tauro-β-muricholic Acid Sodium Salt;Tauro-β-Muricholic Acid-[d5] Sodium Salt;2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt
- CBNumber
- CB24667085
- Molecular Formula
- C26H46NNaO7S
- Formula Weight
- 539.7
- MOL File
- 145022-92-0.mol
Tauro--muricholic Acid (sodium salt) Property
- Melting point:
- 120-125oC
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Pale Beige
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 20289
- Product name
- Tauro-β-muricholic Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 20289
- Product name
- Tauro-β-muricholic Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 20289
- Product name
- Tauro-β-muricholic Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $424
- Updated
- 2024/03/01
- Product number
- T009135
- Product name
- Tauro-β-muricholicAcidSodiumSalt
- Packaging
- 0.5mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- 3131EL
- Product name
- Tauro-beta-muricholicacid(sodium)
- Packaging
- 1mg
- Price
- $248
- Updated
- 2021/12/16
Tauro--muricholic Acid (sodium salt) Chemical Properties,Usage,Production
Description
Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid . TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor. TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.
Uses
Tauro-β-muricholic Acid Sodium Salt is the salt form of Tauro-α-muricholic Acid which is a bile acid released by the liver and is typically used in cholestasis studies.
in vivo
T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].
| Animal Model: | APCmin/+ mice[3] |
| Dosage: | 400 mg/kg |
| Administration: | Oral gavage; twice a week; for 6 weeks |
| Result: | Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon. |
References
[1] SAMA I SAYIN. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.[J]. Cell metabolism, 2013, 17 2: 225-235. DOI: 10.1016/j.cmet.2013.01.003
[2] A. WAHLSTR?M. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota[S][J]. Journal of Lipid Research, 2017, 58 1: 412-419. DOI: 10.1194/jlr.m072819
[3] YUNPENG QI . Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 1: Pages 19-29. DOI: 10.1016/j.bbalip.2014.04.008
Tauro--muricholic Acid (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
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