Geldanamycin-Biotin Property

Boiling point:

1275.6±65.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 10 mg/ml)

form 

powder

pka

8.60±0.70(Predicted)

color 

Purple

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Geldanamycin-Biotin Chemical Properties,Usage,Production

Description

Geldanamycin-biotin (1320265-38-0) is a useful biotinylated ligand for affinity purification of HSP-90 and HSP-90- dependent client proteins.

Uses

Geldanamycin-biotin is a biotinylated ligand for affinity purification of HSP-90 and HSP-90-dependent proteins.

Biochem/physiol Actions

Geldanamycin-Biotin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (HeatShock Protein 90). and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the HSP90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stess response.

References

1) Clevenger?et al.?(2004),?Biotinylated geldanamycin; J. Org. Chem.,?69?4375