ChemicalBook > CAS DataBase List > Morphothiadin

Morphothiadin

Product Name: Morphothiadin
CAS No.: 1092970-12-1
Chemical Name: Morphothiadin
Synonyms: GLS4 (GLS 4;Morphothiadin;Morphothiadin (GLS4);GLS 4(Morphothiadin);Morphothiadin USP/EP/BP;Morphothiadin, 10 mM in DMSO;Morphothiadin,inhibit,HBV,Inhibitor,GLS-4,GLS 4,Hepatitis B virus;Ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 4-(2-bromo-4-fluorophenyl)-1,4-dihydro-6-(4-morpholinylmethyl)-2-(2-thiazolyl)-, ethyl ester
CBNumber: CB24673505
Molecular Formula: C21H22BrFN4O3S
Formula Weight: 509.39
MOL File: 1092970-12-1.mol

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Morphothiadin Property

Boiling point:: 577.2±60.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 12 mg/ml; DMSO: 1 mg/ml; Ethanol: Slightly soluble; PBS (pH 7.2): 0.3 mg/ml
form: A solid
pka: 8.38±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M725025
Product name: Morphothiadin
Packaging: 1mg
Price: $405
Updated: 2021/12/16

ChemScene

Product number: CS-0031547
Product name: Morphothiadin
Purity: 99.05%
Packaging: 5mg
Price: $708
Updated: 2021/12/16

ChemScene

Product number: CS-0031547
Product name: Morphothiadin
Purity: 99.05%
Packaging: 10mg
Price: $1068
Updated: 2021/12/16

ChemScene

Product number: CS-0031547
Product name: Morphothiadin
Purity: 99.05%
Packaging: 25mg
Price: $2148
Updated: 2021/12/16

ChemScene

Product number: CS-0031547
Product name: Morphothiadin
Purity: 99.05%
Packaging: 50mg
Price: $3240
Updated: 2021/12/16

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Morphothiadin Chemical Properties,Usage,Production

Uses

Morphothiadin, is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM. It strongly inhibits virus accumulation in the supernatant of HepAD38 cells at 25 nM to 100 nM (P<0.02).

in vivo

The area under the concentration-time curve from 0 to 24 h (AUC_0-24) of Morphothiadin (GLS4) is 556 h ng/mL. After intravenous administration of 10 mg/kg Morphothiadin, the total plasma clearance and apparent volume distribution are 4.2 liters/h/kg and 7.38 liters/kg, respectively. The bioavailability of Morphothiadin is 25.5%. It is found that virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while Morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment^[2].

Morphothiadin Preparation Products And Raw materials

Raw materials

Preparation Products

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Morphothiadin Suppliers

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View Lastest Price from Morphothiadin manufacturers

Dideu Industries Group Limited

Product: Morphothiadin 1092970-12-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-21

Shaanxi Dideu Medichem Co. Ltd

Product: Morphothiadin 1092970-12-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 Tons
Release date: 2020-05-03

1092970-12-1, MorphothiadinRelated Search:

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Morphothiadin

GLS4 (GLS 4

5-Pyrimidinecarboxylic acid, 4-(2-bromo-4-fluorophenyl)-1,4-dihydro-6-(4-morpholinylmethyl)-2-(2-thiazolyl)-, ethyl ester

Morphothiadin USP/EP/BP

GLS 4(Morphothiadin)

Morphothiadin (GLS4)

Morphothiadin,inhibit,HBV,Inhibitor,GLS-4,GLS 4,Hepatitis B virus

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Morphothiadin, 10 mM in DMSO

1092970-12-1

C21H22BrFN4O3S