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Adefovir

Description References
Product Name
Adefovir
CAS No.
106941-25-7
Chemical Name
Adefovir
Synonyms
PMEA;GS-393;gs0393;Adefovi;ADEFOVIR;A Duff Vee;Adefovir98%;Adefovir API;adefovir ,97%;Adefovir(PMEA)
CBNumber
CB2698137
Molecular Formula
C8H12N5O4P
Formula Weight
273.19
MOL File
106941-25-7.mol
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Adefovir Property

Melting point:
>260°C
Boiling point:
632.5±65.0 °C(Predicted)
Density 
1.88
storage temp. 
-20°C
solubility 
0.1 M NaOH: ≥5mg/mL
form 
powder
pka
pKa1 2.0, pKa2 6.8(at 25℃)
color 
white to beige
InChIKey
SUPKOOSCJHTBAH-UHFFFAOYSA-N
CAS DataBase Reference
106941-25-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
2811
WGK Germany 
3
RTECS 
SZ6563500
HazardClass 
6.1
PackingGroup 
HS Code 
29339900
Hazardous Substances Data
106941-25-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0240
Product name
Adefovir
Purity
≥98% (HPLC)
Packaging
10mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0240
Product name
Adefovir
Purity
≥98% (HPLC)
Packaging
50mg
Price
$441
Updated
2024/03/01
Cayman Chemical
Product number
18650
Product name
Adefovir
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18650
Product name
Adefovir
Purity
≥95%
Packaging
50mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18650
Product name
Adefovir
Purity
≥95%
Packaging
100mg
Price
$243
Updated
2024/03/01
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Adefovir Chemical Properties,Usage,Production

Description

Adefovir (Trade name: Preveon, Hepsera) is a prescription drug used for the treatment of chronic infections of hepatitis B virus. It can be formulated as the pivoxil prodrug adefovir dipivoxil. However, it shows no effect against HIV-1. As a orally administrated acyclic nucleotide analog reverse transcriptase inhibitor, it blocking the reproduction of HBV through inhibiting the reverse transcriptase in the body. One of its advantages over another anti-HBV drug, lamivudine is that it is much harder for the virus to develop resistance to it.

References

https://www.drugbank.ca/drugs/DB00718
http://en.wikipedia.org/wiki/Adefovir

Chemical Properties

Pale Brown Solid

Uses

Used as an antiviral

Uses

Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.

Definition

ChEBI: Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir(1-).

Acquired resistance

It has a lower propensity to induce drug resistance than lamivudine. Clinical trials of patients receiving 48 weeks of therapy did not identify any cases of resistance. Longer courses yield resistant strains of HBV with mutations in the DNA polymerase gene; other rare variants of resistant strains have been identified. Lamivudine-resistant strains of HBV retain susceptibility to adefovir.

Pharmaceutical Applications

A nucleotide analog of adenosine monophosphate, administered orally as its prodrug, adefovir dipivoxil.

Biochem/physiol Actions

Adefovir is an antiviral drug that after intracellular conversion to adefovir diphosphate inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase).

Pharmacokinetics

Oral absorption: c. 60%
Cmax 10 mg/kg oral: 18.4 ng/mL
Plasma half-life: c. 7.5 h.
Volume of distribution: 392 mL/kg
Plasma protein binding: Not known
The prodrug is metabolized to adefovir, which is excreted by the kidneys and therefore requires dose adjustment in patients with impaired renal function. It does not induce cytochrome P450 at standard doses and does not influence the metabolism or plasma concentrations of the other licensed medications used in the treatment of hepatitis B.

Clinical Use

Treatment of chronic hepatitis B virus infection in patients >12 years of age

Side effects

It is generally well tolerated, with headache, pharyngitis, abdominal pain and peripheral neuropathy being the most common side effects. Nephrotoxicity has been observed in some patients, with those receiving higher doses and longer courses of therapy at greater risk. Exacerbation of hepatitis has been reported in patients immediately following discontinuation of treatment. Most exacerbations occur within 12 weeks of stopping therapy, and elevations of alanine aminotransferase (ALT) up to 10 times the upper limit of normal can be observed in over 25% of patients. Lactic acidosis has been reported in a few patients and is an indication for immediate discontinuation.

Adefovir Preparation Products And Raw materials

Raw materials

Preparation Products

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Adefovir Suppliers

Cangzhou Weizhidamei Pharmaceutical Co., Ltd.
Tel
13426038769 13426038769
Fax
0317-5486999
Email
askmryu@163.com
Country
China
ProdList
60
Advantage
58
Huangshi Jingchi?Medicine?Co.,?Ltd
Tel
17771967576; 17771967576
Email
234107690@qq.com
Country
China
ProdList
609
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
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View Lastest Price from Adefovir manufacturers

Sinoway Industrial co., ltd.
Product
Adefovir 106941-25-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-09-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Adefovir 106941-25-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
500kgs
Release date
2021-09-16
Hebei Weibang Biotechnology Co., Ltd
Product
Adefovir 106941-25-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

106941-25-7, AdefovirRelated Search:


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  • Adefovir Dipivoxil Impurity (Adefovir)
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