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5-Amino-2-chlorobenzonitrile

Product Name
5-Amino-2-chlorobenzonitrile
CAS No.
35747-58-1
Chemical Name
5-Amino-2-chlorobenzonitrile
Synonyms
4-Chloro-3-cyanoaniline;3-CYANO-4-CHLOROANILINE HCL;5-AMINO-2-CHLOROBENZONITRILE;5-aMino-5-chlorobenzonitrile;2-CHLORO-5-AMINO BENZONITRILE;Benzonitrile, 5-amino-2-chloro-
CBNumber
CB2471422
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
35747-58-1.mol
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5-Amino-2-chlorobenzonitrile Property

Melting point:
115.5°C
Boiling point:
250.67°C (rough estimate)
Density 
1.9802 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.15±0.10(Predicted)
Appearance
Light yellow to brown Solid
CAS DataBase Reference
35747-58-1(CAS DataBase Reference)
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A617703
Product name
5-Amino-2-chlorobenzonitrile
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J51655
Product name
3-Cyano-4-chloroanilineHCl
Packaging
5g
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67240
Product name
5-Amino-2-chlorobenzonitrile
Packaging
10g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
D146
Product name
3-Cyano-4-chloroanilineHCl
Packaging
5g
Price
$61
Updated
2021/12/16
AK Scientific
Product number
J51655
Product name
3-Cyano-4-chloroanilineHCl
Packaging
10g
Price
$80
Updated
2021/12/16
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5-Amino-2-chlorobenzonitrile Chemical Properties,Usage,Production

Uses

5-Amino-2-chlorobenzonitrile is a useful research reagent for organic synthesis and other chemical transformations.

Synthesis

16588-02-6

35747-58-1

The general procedure for the synthesis of 3-cyano-4-chloroaniline from 2-chloro-5-nitrobenzonitrile was as follows: 2-chloro-5-nitrobenzonitrile (10 g, 54.8 mmol) was heated and refluxed for 1 h in a mixture of isopropanol (125 mL) and concentrated hydrochloric acid (62.5 mL) with stannous chloride dihydrate (56 g, 248.6 mmol). Upon completion of the reaction, the mixture was cooled to room temperature and neutralized with 2N sodium hydroxide solution. Subsequently, the aqueous layer was extracted with dichloromethane, the organic layers were combined and dried with anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to afford 3-cyano-4-chloroaniline (8 g, 96% yield). The product was analyzed by high performance liquid chromatography (HPLC) under the following purity detection conditions: detection wavelength 210-370 nm; retention time (RT) 7.2 min; mobile phase 10 mM ammonium formate buffer (pH 3.5)/acetonitrile + methanol (gradient elution from 85/15 to 5/95) for 10 min, hold for 4 min; chromatography column Xterra TM RP18 (3.5 μm, 150×4.6 mm); mobile phase 1.5 μm, 2.5 μm, 2.5 μm, 2.5 μm, 2.5 μm, 2.5 μm. m, 150×4.6 mm); the flow rate was 1.2 mL/min.

References

[1] Tetrahedron Letters, 1984, vol. 25, # 8, p. 839 - 842
[2] Patent: US2007/27126, 2007, A1. Location in patent: Page/Page column 16
[3] Patent: US2007/27201, 2007, A1. Location in patent: Page/Page column 23
[4] Patent: US9204645, 2015, B2. Location in patent: Page/Page column 54; 55
[5] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 3, p. 685 - 695

5-Amino-2-chlorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-2-chlorobenzonitrile Suppliers

China 96 Germany 1 India 2 Ukraine 2 United Kingdom 2 United States 13 Global 116
Enamine
Tel
--
Fax
--
Email
enamine@enamine.net
Country
Ukraine
ProdList
6216
Advantage
67
CAS Organic Company
Tel
--
Fax
--
Email
Sales@casorganic.com
Country
Ukraine
ProdList
5026
Advantage
34
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View Lastest Price from 5-Amino-2-chlorobenzonitrile manufacturers

Career Henan Chemical Co
Product
5-Amino-2-chlorobenzonitrile 35747-58-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kgs
Release date
2019-12-25

35747-58-1, 5-Amino-2-chlorobenzonitrileRelated Search:

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  • 4-Chloro-3-cyanoaniline
  • Benzonitrile, 5-amino-2-chloro-
  • 35747-58-1