3-AMINO-4-CHLOROBENZONITRILE

Application

Product Name: 3-AMINO-4-CHLOROBENZONITRILE
CAS No.: 53312-79-1
Chemical Name: 3-AMINO-4-CHLOROBENZONITRILE
Synonyms: 2-CHLORO-5-CYANO-ANILINE;3-AMINO-4-CHLOROBENZONITRILE;Benzonitrile, 3-amino-4-chloro-;3-Amino-4-chlorobenzonitrile >3-Amino-4-chlorobenzonitrile 96%;3-AMINO-4-CHLOROBENZONITRILE ISO 9001：2015 REACH
CBNumber: CB9323805
Molecular Formula: C7H5ClN2
Formula Weight: 152.58
MOL File: 53312-79-1.mol

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3-AMINO-4-CHLOROBENZONITRILE Property

Melting point:: 87-91 °C
Boiling point:: 292.0±20.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 0.85±0.10(Predicted)
color: Light yellow to Yellow to Orange
CAS DataBase Reference: 53312-79-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
RIDADR: 3439
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2105
Product name: 3-Amino-4-chlorobenzonitrile
Purity: >97.0%(GC)
Packaging: 1g
Price: $44
Updated: 2023/06/20

TCI Chemical

Product number: A2105
Product name: 3-Amino-4-chlorobenzonitrile
Purity: >97.0%(GC)
Packaging: 5g
Price: $127
Updated: 2023/06/20

Matrix Scientific

Product number: 074292
Product name: 3-Amino-4-chlorobenzonitrile
Purity: 95+%
Packaging: 5g
Price: $24
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA64100
Product name: 3-Amino-4-chlorobenzonitrile
Packaging: 50g
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 074292
Product name: 3-Amino-4-chlorobenzonitrile
Purity: 95+%
Packaging: 25g
Price: $74
Updated: 2021/12/16

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3-AMINO-4-CHLOROBENZONITRILE Chemical Properties,Usage,Production

Application

3-Amino-4-chlorobenzonitrile is a pharmaceutical intermediate. Literature reports that 3-amino-4-chlorobenzonitrile can be used to prepare 2-amino-4-cyano-3',4'-difluoro-1,1'-biphenyl. Fluorinated benzidines are an important class of intermediates widely used in the industrial production of pesticides, pharmaceuticals and other fields.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 9305, 1995 DOI: 10.1016/0040-4039(95)02003-8

Synthesis

939-80-0

53312-79-1

General procedure for the synthesis of 3-amino-4-chlorobenzonitrile from 4-chloro-3-nitrobenzonitrile: Example 1: Preparation of N-(1-(5-cyano-2-(3,5-dichlorophenoxy)benzenesulfonyl)piperidin-4-yl)-3-fluorobenzenesulfonamide (25) 1. Commercially available 4-chloro-3-nitrobenzonitrile was dissolved in tetrahydrofuran (THF) with solvent dosage of 4 times the volume of the raw material. 2. Sodium hydrosulfide (3 equiv.) was added to the reaction system and the reaction mixture was stirred at 45 °C overnight. 3. The progress of the reaction was monitored using thin layer chromatography (TLC) with the unfolding agent being a hexane solution of 25% ethyl acetate to confirm the completion of the reaction. 4. Upon completion of the reaction, the THF solvent was removed by rotary evaporator under reduced pressure to precipitate the product. 5. The white solid product was collected by vacuum filtration and washed with water to remove impurities. 6. 6. The product was placed in a vacuum oven and dried under mild heating conditions to obtain the target compound in 97.0% yield.

References

[1] Patent: US2011/230487, 2011, A1. Location in patent: Page/Page column 35
[2] Synlett, 2010, # 20, p. 3019 - 3022
[3] Patent: US2012/196824, 2012, A1
[4] Recueil des Travaux Chimiques des Pays-Bas, 1947, vol. 66, p. 369
[5] Chem.Abstr., 1948, vol. 42, p. 148

3-AMINO-4-CHLOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-4-CHLOROBENZONITRILE Suppliers

Americas 1 China 99 Europe 3 France 1 Germany 1 India 3 Switzerland 1 United Kingdom 6 United States 19 Global 134

J & K SCIENTIFIC LTD.

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View Lastest Price from 3-AMINO-4-CHLOROBENZONITRILE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-AMINO-4-CHLOROBENZONITRILE 53312-79-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-18

Career Henan Chemical Co

Product: 3-AMINO-4-CHLOROBENZONITRILE 53312-79-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-03

53312-79-1, 3-AMINO-4-CHLOROBENZONITRILERelated Search:

2-AMINO-3-CHLOROBENZONITRILE 2-AMINO-4-CHLOROBENZONITRILE,2-AMINO-4-CHLOROBENZONITRILE PURUM 97%,2-AMINO- 4-CHLOROBENZONITRILE(5-CHLORO-2-CYANOANILINE ) 4-AMINO-2-CHLOROBENZONITRILE,4-Amino-2-chlorobenzonitrile 99%,4-AMINO-2-CHLOROBENZONITRILE, 98+% 2-AMINO-5-CHLOROBENZONITRILE 5-AMINO-2-CHLOROBENZONITRILE 6-Amino-2-chlorobenzonitrile,2-AMINO-6-CHLOROBENZONITRILE 4-AMINO-3-CHLOROBENZONITRILE 3-Amino-5-chlorobenzonitrile 97% 4-Chloro-3-nitrobenzonitrile 4-CHLORO-3,5-DINITROBENZONITRILE 3-AMINO-4-CHLOROBENZONITRILE 4-Chlorobenzonitrile N-ALLYL-N-(2-CHLORO-5-CYANOPHENYL)ACETAMIDE lodoxamide ethyl Lodoxamide N-(5-CYANO-2-CHLOROPHENYL)ACETAMIDE 3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile Lodoxamidetromethamine

3-Amino-4-chlorobenzonitrile 96%

2-CHLORO-5-CYANO-ANILINE

3-AMINO-4-CHLOROBENZONITRILE

3-Amino-4-chlorobenzonitrile &gt

Benzonitrile, 3-amino-4-chloro-

3-AMINO-4-CHLOROBENZONITRILE ISO 9001：2015 REACH

53312-79-1

ClC6H3NH2CN

Building Blocks

C6 to C7

Nitrogen Compounds

Organic Building Blocks

Cyanides/Nitriles

Nitrogen Compounds

Building Blocks

C6 to C7

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Aromatic Nitriles

C6 to C7