4-Chloro-2-iodoaniline
Uses- Product Name
- 4-Chloro-2-iodoaniline
- CAS No.
- 63069-48-7
- Chemical Name
- 4-Chloro-2-iodoaniline
- Synonyms
- oro-2-iodoaniL;4-Chloro-2-iodoanili;4-CHLORO-2-IODOANILINE;2-IODO-4-CHLOROANILINE;4-Chloro-2-lodoaniline;4-ChIoro-2-Iodoaniline;p-chloro-o-iodoaniline;4-Chloro-2-iodoanilineE;2-iodine-4-chloroaniline;4-CHLORO-2-IODOANILINE 98%
- CBNumber
- CB2475288
- Molecular Formula
- C6H5ClIN
- Formula Weight
- 253.47
- MOL File
- 63069-48-7.mol
4-Chloro-2-iodoaniline Property
- Melting point:
- 40 °C
- Boiling point:
- 295.0±25.0 °C(Predicted)
- Density
- 2.015±0.06 g/cm3(Predicted)
- Flash point:
- >110 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Methanol
- form
- Powder
- pka
- 1.90±0.10(Predicted)
- color
- White to off-white
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H5ClIN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
- InChIKey
- FLEJOBRWKBPUOX-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Cl)C=C1I
- CAS DataBase Reference
- 63069-48-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N,T
- Risk Statements
- 20/21/22-36/37/38-51/53-41-37/38-25
- Safety Statements
- 26-36/37/39-61-45
- RIDADR
- UN 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 516139
- Product name
- 4-Chloro-2-iodoaniline
- Purity
- 98%
- Packaging
- 5g
- Price
- $58.52
- Updated
- 2025/07/31
- Product number
- C1800
- Product name
- 4-Chloro-2-iodoaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- C1800
- Product name
- 4-Chloro-2-iodoaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $290
- Updated
- 2025/07/31
- Product number
- C349520
- Product name
- 4-Chloro-2-iodoaniline
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C349520
- Product name
- 4-Chloro-2-iodoaniline
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
4-Chloro-2-iodoaniline Chemical Properties,Usage,Production
Uses
Iodinated aminoaryl compounds such as 2-iodo-4-chloroaniline are of considerable value as synthetic intermediates and can be used in a variety of industrial environments, including the pharmaceutical industry.
Chemical Properties
Pale brown to purple low melting solid
Synthesis
106-47-8
63069-48-7
88149-53-5
General method: 4-Chloroaniline (20.0 mmol) was dissolved in a solvent mixture of H2O (100 mL) and MeOH (300 mL) and the pH was adjusted to 1-2 by adding concentrated HCl (tested using pH paper). Subsequently, NaICl2 aqueous solution (50% w/w, 1.1-4.8 molar equivalents, see table for exact dosage) was slowly added dropwise and the reaction mixture was stirred for 3-4 hours at room temperature. Upon completion of the reaction, the reaction was quenched by adding saturated NaHSO3 aqueous solution until the starch test was negative. If no significant precipitate was generated in the reaction mixture, the pH was adjusted to alkaline by dropwise addition of 1 M NaOH aqueous solution (tested using pH paper), followed by extraction with Et2O. The organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give the solid product. If a precipitate was generated in the reaction mixture, the solid was first separated by gravity filtration, then the filtrate was adjusted to slightly basic (using 1 M NaOH aqueous solution) and extracted with Et2O. The organic extracts were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give the solid product. All solid products were analyzed by TLC (silica gel plates, different ratios of hexane/ethyl acetate as unfolding agent). If the products were mixtures, they were separated and purified by fast column chromatography (silica gel, hexane/ethyl acetate = 9:1, unless otherwise stated). The final products were characterized by melting point (compared to literature values), IR, MS, 1H-NMR, 13C-NMR spectra and elemental analysis (for new compounds). It should be noted that the reaction products of anilines 1a-1j are mostly known compounds, while theanisidines failed to yield characterizable products.
References
[1] Organic Preparations and Procedures International, 2016, vol. 48, # 5, p. 385 - 392
[2] Synlett, 2014, vol. 25, # 6, p. 831 - 834
4-Chloro-2-iodoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-iodoaniline Suppliers
- Tel
- 18602598900，18605190599 18602598900
- 1669093670@qq.com
- Country
- China
- ProdList
- 94
- Advantage
- 58
- Tel
- 15855184105
- 3150278607@qq.com
- Country
- China
- ProdList
- 63
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 5108538618
- Fax
- 86 510 85386988-8017
- suger.wang@chemfuture.com
- Country
- China
- ProdList
- 832
- Advantage
- 65
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2807
- Advantage
- 65
View Lastest Price from 4-Chloro-2-iodoaniline manufacturers
- Product
- 4-Chloro-2-iodoaniline 63069-48-7
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
- Product
- 4-Chloro-2-iodoaniline 63069-48-7
- Price
- US $0.00-0.00/drums
- Min. Order
- 1drums
- Purity
- 99%min.
- Supply Ability
- 10tons
- Release date
- 2023-10-22
- Product
- 4-Chloro-2-iodoaniline 63069-48-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24